Assembly with the NR1 Subunit Is Required for Surface Expression of NR3A-Containing NMDA Receptors
Pérez-Otaño I, Schulteis C, Contractor A, Lipton S, Trimmer J, Sucher N, Heinemann S. Assembly with the NR1 Subunit Is Required for Surface Expression of NR3A-Containing NMDA Receptors. Journal Of Neuroscience 2001, 21: 1228-1237. PMID: 11160393, PMCID: PMC6762235, DOI: 10.1523/jneurosci.21-04-01228.2001.Peer-Reviewed Original ResearchConceptsEndoplasmic reticulumNR1-1aPlasma membrane targetingReceptor complexRelative calcium permeabilityNR2 subunitsNR1 subunitSurface expressionMembrane targetingSubunit oligomerizationHeteromultimeric complexesHeteromeric complexesAdditional subunitsNMDA receptor familyPlasma membraneIntracellular traffickingDistinct single-channel propertiesIntracellular clustersFunctional NMDA receptorsSubunitsReceptor familyCell surfaceNMDA receptor subunitsMembrane expressionReticulumPotential and Current Use of N-Methyl-D-Aspartate (NMDA) Receptor Antagonists in Diseases of Aging
Le D, Lipton S. Potential and Current Use of N-Methyl-D-Aspartate (NMDA) Receptor Antagonists in Diseases of Aging. Drugs & Aging 2001, 18: 717-724. PMID: 11735619, DOI: 10.2165/00002512-200118100-00001.Peer-Reviewed Original ResearchConceptsReceptor antagonistN-methyl-D-aspartate receptor antagonistN-methyl-D-aspartate (NMDA) receptor complexSafe NMDA antagonistMultiple clinical trialsNMDA receptor antagonistChronic painClinical trialsNMDA antagonistsGlutamate receptorsParkinson's diseaseNeurological disordersNeurodegenerative diseasesDiseaseAdverse effectsAntagonistReceptor complexCurrent useDrugsAdequate levelPainMemantineDysfunctionNitroglycerinStroke