2024
Using in vivo intact structure for system-wide quantitative analysis of changes in proteins
Son A, Kim H, Diedrich J, Bamberger C, McClatchy D, Lipton S, Yates J. Using in vivo intact structure for system-wide quantitative analysis of changes in proteins. Nature Communications 2024, 15: 9310. PMID: 39468068, PMCID: PMC11519357, DOI: 10.1038/s41467-024-53582-x.Peer-Reviewed Original ResearchConceptsAlzheimer's diseaseProtein footprinting methodGlobal expression profilingIn vivo conformationStructural alterations of proteinsCo-expressed proteinsMass spectrometry-based methodsAlterations of proteinsProteostasis dysfunctionSpectrometry-based methodsProtein misfoldingConformation of proteinsStructural changesLysine residuesDynamic structural changesBiological functionsProteomics experimentsDimethyl labelingExpression profilesProtein conformationConformational changesProteinIntact proteinDesign of therapeutic interventionsMeasuring dynamic structural changes
2021
Protein S-Nitrosylation in Neuronal Development
Nakamura T, Zhang X, Oh C, Lipton S. Protein S-Nitrosylation in Neuronal Development. 2021, 91-105. DOI: 10.1201/9781003204091-10.Peer-Reviewed Original ResearchPost-translational modificationsProtein S-nitrosylationS-nitrosylationReactive nitrogen speciesNeuronal developmentNeuronal differentiationTranscription factor MEF2Protein-protein interactionsIon channel activityProtein traffickingEnzymatic functionCysteine thiolsProtein conformationCellular mechanismsChannel activityNormal brain developmentNitrogen speciesSynaptic functionNitric oxide actsPathological processesBiological actionsProteinNeuronal survivalBiological systemsNeurogenesis