2007
Neuroinflammation and Excitotoxicity in Neurobiology of HIV-1 Infection and AIDS: Targets for Neuroprotection
Kaul M, Lipton S. Neuroinflammation and Excitotoxicity in Neurobiology of HIV-1 Infection and AIDS: Targets for Neuroprotection. 2007, 281-308. DOI: 10.1007/978-0-387-70830-0_13.Peer-Reviewed Original ResearchHuman immunodeficiency virus-1Central nervous systemMild behavioral abnormalitiesHIV-1 infectionImmune competent cellsImmunodeficiency virus-1Persistent health problemsFrank dementiaImmunodeficiency syndromeMotor dysfunctionInflammatory responseNeurological problemsParticular macrophagesBehavioral abnormalitiesNervous systemHealth problemsVirus 1InfectionBrainCell typesNeuroinflammationExcitotoxicityNeuroprotectionDysfunctionSyndrome
1999
Attenuation of NMDA Receptor Activity and Neurotoxicity by Nitroxyl Anion, NO−
Kim W, Choi Y, Rayudu P, Das P, Asaad W, Arnelle D, Stamler J, Lipton S. Attenuation of NMDA Receptor Activity and Neurotoxicity by Nitroxyl Anion, NO−. Neuron 1999, 24: 461-469. PMID: 10571239, DOI: 10.1016/s0896-6273(00)80859-4.Peer-Reviewed Original Research
1998
Neuroprotective versus neurodestructive effects of NO‐related species
Lipton S, Choi Y, Sucher N, Chen H. Neuroprotective versus neurodestructive effects of NO‐related species. BioFactors 1998, 8: 33-40. PMID: 9699006, DOI: 10.1002/biof.5520080107.Peer-Reviewed Original ResearchConceptsNMDA receptorsCentral nervous systemNMDA receptor subunitsNeuronal injuryNeurodestructive effectsNervous systemRedox modulationReceptor subunitsNitric oxideExcessive Ca2Protective actionChannel activitySuperoxide anionNO groupReceptorsS-nitrosylationGroupDiverse tissuesNeuroprotectionInjuryBrain
1997
Janus faces of NF-κB: Neurodestruction versus neuroprotection
Lipton S. Janus faces of NF-κB: Neurodestruction versus neuroprotection. Nature Medicine 1997, 3: 20-22. PMID: 8986730, DOI: 10.1038/nm0197-20.Peer-Reviewed Original ResearchMeSH KeywordsAntigens, CDAnti-Inflammatory Agents, Non-SteroidalApoptosisAspirinCell DeathCerebrovascular DisordersCyclooxygenase InhibitorsDose-Response Relationship, DrugHumansNeuronsNF-kappa BReactive Oxygen SpeciesReceptors, Tumor Necrosis FactorReceptors, Tumor Necrosis Factor, Type ISignal TransductionTumor Necrosis Factor-alphaConceptsNF-κBNeuronal cell deathNeuroprotective roleCell deathNeuroprotectionAspirinNeurodestruction
1991
Glutathione prevents N -methyl-d-aspartate receptor-mediated neurotoxicity
Levy D, Sucher N, Lipton S. Glutathione prevents N -methyl-d-aspartate receptor-mediated neurotoxicity. Neuroreport 1991, 2: 345-347. PMID: 1832987, DOI: 10.1097/00001756-199106000-00011.Peer-Reviewed Original ResearchConceptsN-methyl-D-aspartate receptor-mediated neurotoxicityNMDA receptor-channel complexSafe NMDA antagonistNMDA receptor activationPossible therapeutic modalityReceptor-channel complexNeuronal damageNMDA antagonistsNMDA receptorsTherapeutic modalitiesExcessive stimulationNeurodegenerative conditionsReceptor activationExtracellular mechanismsAntagonistPresent studyGlutathioneNeuroprotectionNeurotoxicityStrokeN-methylTraumaBrainReceptors