2001
Structure and function of GABAC receptors: a comparison of native versus recombinant receptors
Zhang D, Pan Z, Awobuluyi M, Lipton S. Structure and function of GABAC receptors: a comparison of native versus recombinant receptors. Trends In Pharmacological Sciences 2001, 22: 121-132. PMID: 11239575, DOI: 10.1016/s0165-6147(00)01625-4.Peer-Reviewed Original ResearchConceptsRecombinant receptorsGABA receptorsIonotropic GABA receptorsRetinal signal processingInhibitory receptorsGABAC receptorsPharmacological profileBrain regionsSpecific drugsReceptorsNative receptorMajor molecular componentsUnique functional rolesFunctional roleMolecular determinantsSlow activationCompelling evidenceSubunit compositionMolecular basisRetina
1995
Cloning of a gamma-aminobutyric acid type C receptor subunit in rat retina with a methionine residue critical for picrotoxinin channel block.
Zhang D, Pan Z, Zhang X, Brideau A, Lipton S. Cloning of a gamma-aminobutyric acid type C receptor subunit in rat retina with a methionine residue critical for picrotoxinin channel block. Proceedings Of The National Academy Of Sciences Of The United States Of America 1995, 92: 11756-11760. PMID: 8524843, PMCID: PMC40481, DOI: 10.1073/pnas.92.25.11756.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsBase SequenceChloride ChannelsCloning, MolecularDose-Response Relationship, DrugDrug ResistanceElectric ConductivityGABA AntagonistsIon ChannelsMethionineMolecular Sequence DataMutagenesis, Site-DirectedPicrotoxinProtein ConformationRatsReceptors, GABARetinaSequence Homology, Amino AcidSesterterpenesStructure-Activity RelationshipConceptsGABAC responsesRat retinaRho 2 subunitsGamma-aminobutyric acidPTX resistanceHeteromeric receptorsReceptor subunitsFunctional homomeric receptorsRho 1 receptorsGABA receptor subunitsInhibitory neurotransmissionMechanism of blockGABA receptorsMammalian retinaConvulsant picrotoxininHomomeric receptorsRat receptorRetinaIonotropic receptorsReceptorsChannel blockPicrotoxininSecond membrane-spanning regionNative receptorPredominant determinant