2001
Assembly with the NR1 Subunit Is Required for Surface Expression of NR3A-Containing NMDA Receptors
Pérez-Otaño I, Schulteis C, Contractor A, Lipton S, Trimmer J, Sucher N, Heinemann S. Assembly with the NR1 Subunit Is Required for Surface Expression of NR3A-Containing NMDA Receptors. Journal Of Neuroscience 2001, 21: 1228-1237. PMID: 11160393, PMCID: PMC6762235, DOI: 10.1523/jneurosci.21-04-01228.2001.Peer-Reviewed Original ResearchConceptsEndoplasmic reticulumNR1-1aPlasma membrane targetingReceptor complexRelative calcium permeabilityNR2 subunitsNR1 subunitSurface expressionMembrane targetingSubunit oligomerizationHeteromultimeric complexesHeteromeric complexesAdditional subunitsNMDA receptor familyPlasma membraneIntracellular traffickingDistinct single-channel propertiesIntracellular clustersFunctional NMDA receptorsSubunitsReceptor familyCell surfaceNMDA receptor subunitsMembrane expressionReticulum
2000
Redox modulation of the NMDA receptor
Choi Y, Lipton S. Redox modulation of the NMDA receptor. Cellular And Molecular Life Sciences 2000, 57: 1535-1541. PMID: 11092448, PMCID: PMC11147125, DOI: 10.1007/pl00000638.Peer-Reviewed Original ResearchConceptsRedox modulationCysteine residuesCritical cysteine residuesMultiple cysteine residuesDifferent NMDA receptor subunitsS-nitrosylationMolecular mechanismsMolecular determinantsNMDA receptor subunitsDistinct mechanismsReceptor subunitsPhysiological conditionsSubunitsNR2A subunitImportant mechanismN-methyl-D-aspartate receptorsResiduesNMDA receptorsRedox formsReceptorsCyclic GMPSpeciesMechanismForm of modulationRegulation
1999
Redox Sensitivity of NMDA Receptors
Lipton S. Redox Sensitivity of NMDA Receptors. Methods In Molecular Biology 1999, 128: 121-130. PMID: 10320978, DOI: 10.1385/1-59259-683-5:121.Peer-Reviewed Original ResearchConceptsCritical cysteine residuesCysteine residuesRedox modulationProtein cysteine residuesSite-directed mutagenesisEndogenous redox agentsRedox-related speciesFree sulfhydryl groupsProtein functionMolecular dataSulfhydryl groupsSufficient redox potentialCysteine sulfhydrylsRedox sensitivityCell typesNative NMDA receptorsDisulfide bondsNMDA receptor subunitsRedox modulatory siteRecombinant methodsReceptor consistReceptor subunitsOxygen speciesSingle thiol groupResidues
1998
Neuroprotective versus neurodestructive effects of NO‐related species
Lipton S, Choi Y, Sucher N, Chen H. Neuroprotective versus neurodestructive effects of NO‐related species. BioFactors 1998, 8: 33-40. PMID: 9699006, DOI: 10.1002/biof.5520080107.Peer-Reviewed Original ResearchConceptsNMDA receptorsCentral nervous systemNMDA receptor subunitsNeuronal injuryNeurodestructive effectsNervous systemRedox modulationReceptor subunitsNitric oxideExcessive Ca2Protective actionChannel activitySuperoxide anionNO groupReceptorsS-nitrosylationGroupDiverse tissuesNeuroprotectionInjuryBrain
1995
Developmental and regional expression pattern of a novel NMDA receptor- like subunit (NMDAR-L) in the rodent brain
Sucher N, Akbarian S, Chi C, Leclerc C, Awobuluyi M, Deitcher D, Wu M, Yuan J, Jones E, Lipton. Developmental and regional expression pattern of a novel NMDA receptor- like subunit (NMDAR-L) in the rodent brain. Journal Of Neuroscience 1995, 15: 6509-6520. PMID: 7472413, PMCID: PMC6578025, DOI: 10.1523/jneurosci.15-10-06509.1995.Peer-Reviewed Original ResearchConceptsLateral olfactory tractLayer VOlfactory tractEntorhinal cortexRegional expression patternsPostnatal day 1NMDA receptor subunitsFunction of NMDARsGlutamate-activated channelsCA1 fieldInferior colliculiRodent CNSAdult brainLayers IIDay 1Triple combinationRodent brainAxonal outgrowthMRNA expressionReceptor subunitsBrain developmentNMDARSubiculumExpression patternsNeocortex