1991
N-methyl-D-aspartate antagonists prevent kainate neurotoxicity in rat retinal ganglion cells in vitro
Sucher N, Aizenman E, Lipton. N-methyl-D-aspartate antagonists prevent kainate neurotoxicity in rat retinal ganglion cells in vitro. Journal Of Neuroscience 1991, 11: 966-971. PMID: 1672708, PMCID: PMC6575374, DOI: 10.1523/jneurosci.11-04-00966.1991.Peer-Reviewed Original ResearchConceptsRetinal ganglion cellsNMDA receptorsGanglion cellsEndogenous GluKA receptorsSpecific NMDA receptor antagonistN-methyl-D-aspartate antagonistsRetinal ganglion cell deathRat retinal ganglion cellsDoses of NMDAGanglion cell deathSpecific NMDA antagonistNMDA receptor antagonistOwn specific receptorsPatch-clamp electrophysiology experimentsAddition of kainateMicroM kainateKainate neurotoxicityReceptor antagonistNMDA antagonistsKainateCellular injuryExogenous glutamateSpecific receptorsDetectable inhibition
1988
The interaction of agonists and noncompetitive antagonists at the excitatory amino acid receptors in rat retinal ganglion cells in vitro
Karschin A, Aizenman E, Lipton. The interaction of agonists and noncompetitive antagonists at the excitatory amino acid receptors in rat retinal ganglion cells in vitro. Journal Of Neuroscience 1988, 8: 2895-2906. PMID: 2842467, PMCID: PMC6569411, DOI: 10.1523/jneurosci.08-08-02895.1988.Peer-Reviewed Original ResearchConceptsExcitatory amino acidsGanglion cellsMK-801Excitatory amino acid receptorsRat retinal ganglion cellsWhole-cell patch-clamp techniqueCultured ganglion cellsKainate-activated currentsKainate-induced currentsAmino acid receptorsConcentrations of NMDAApplication of kainateKainate-induced responsesPresence of NMDAReceptor-ion channel complexRetinal ganglion cellsNoncompetitive NMDA antagonistPatch-clamp techniqueDegree of blockAnticonvulsant MK-801Ganglion cell membraneDissociative anesthetic phencyclidineMicroM kainateKainate currentsLarge inward currentsResponses mediated by excitatory amino acid receptors in solitary retinal ganglion cells from rat.
Aizenman E, Frosch M, Lipton S. Responses mediated by excitatory amino acid receptors in solitary retinal ganglion cells from rat. The Journal Of Physiology 1988, 396: 75-91. PMID: 2842491, PMCID: PMC1192034, DOI: 10.1113/jphysiol.1988.sp016951.Peer-Reviewed Original ResearchConceptsNon-desensitizing currentsDesensitizing componentGanglion cellsInward currentsExcitatory amino acid receptorsExcitatory amino acid responsesAgonist concentrationsWhole-cell voltage-clamp techniqueAmino acid receptorsL-glutamate responsesRetinal ganglion cellsHigh agonist concentrationsAmino acid responsesVoltage-clamp techniqueMicroM kynurenateQuisqualate responseMicroM kainateNMDA responsesNMDA currentsRat retinaAgonist doseQuisqualateAcid receptorsPharmacological propertiesAcid response