2009
Matrix Metalloproteinases in Cerebral Hypoxia-Ischemia
Gu Z, Cui J, Lipton S. Matrix Metalloproteinases in Cerebral Hypoxia-Ischemia. Contemporary Clinical Neuroscience 2009, 225-238. DOI: 10.1007/978-1-60327-579-8_11.Peer-Reviewed Original ResearchNeuronal nitric oxide synthaseAcute cerebral ischemiaCerebral ischemiaMMP-9Neuronal apoptosisCerebral ischemia/reperfusionTransient focal cerebral ischemiaAcute stroke patientsCerebral hypoxia-ischemiaHypoxic-ischemic insultFocal cerebral ischemiaFuture clinical trialsIschemia/reperfusionNitric oxide synthaseMMP-9 activityMMP-2/9 inhibitorNeuronal cell deathShort-term therapyActivation of MMPsS-nitrosylationSignificant therapeutic potentialHypoxia-ischemiaNeuronal injuryIschemic damageStroke patients
1999
Mice Deficient in Mac-1 (CD11b/CD18) Are Less Susceptible to Cerebral Ischemia/Reperfusion Injury
Soriano S, Coxon A, Wang Y, Frosch M, Lipton S, Hickey P, Mayadas T. Mice Deficient in Mac-1 (CD11b/CD18) Are Less Susceptible to Cerebral Ischemia/Reperfusion Injury. Stroke 1999, 30: 134-139. PMID: 9880401, DOI: 10.1161/01.str.30.1.134.Peer-Reviewed Original ResearchConceptsTransient focal cerebral ischemiaRegional cerebral blood flowMac-1-deficient miceFocal cerebral ischemiaCerebral blood flowMac-1Cerebral ischemiaBrain sectionsBlood flowCerebral ischemia/reperfusion injuryFocal ischemia/reperfusionIschemia/reperfusion injuryLeft middle cerebral arteryCerebral cell deathLeukocyte beta2 integrinsIschemic brain tissueReperfusion-induced injuryMiddle cerebral arteryIschemia/reperfusionWild-type miceLaser Doppler flowmeterWild-type cohortsMac-1 deficiencyMacrophage-1 antigenInfarct volume
1998
Tissue plasminogen activator (tPA) increase neuronal damage after focal cerebral ischemia in wild-type and tPA-deficient mice
Wang Y, Tsirka S, Strickland S, Stieg P, Soriano S, Lipton S. Tissue plasminogen activator (tPA) increase neuronal damage after focal cerebral ischemia in wild-type and tPA-deficient mice. Nature Medicine 1998, 4: 228-231. PMID: 9461198, DOI: 10.1038/nm0298-228.Peer-Reviewed Original ResearchConceptsTissue plasminogen activatorTPA-deficient miceWild-type miceCerebral infarctsNeuronal damageEffects of tPAIntravenous tissue plasminogen activatorRole of tPAPlasminogen activatorSmall cerebral infarctsAcute cerebral infarctsFocal cerebral ischemiaMiddle cerebral arteryIschemia/reperfusionStroke-induced injuryCerebral viabilityIntravascular filamentAcute strokeExcitotoxic damageCerebral ischemiaCerebral arteryLarge infarctsIntracerebral injectionIntravenous injectionThrombolytic agents