2000
Involvement of Activated Caspase‐3‐Like Proteases in N‐Methyl‐D‐Aspartate‐Induced Apoptosis in Cerebrocortical Neurons
Tenneti L, Lipton S. Involvement of Activated Caspase‐3‐Like Proteases in N‐Methyl‐D‐Aspartate‐Induced Apoptosis in Cerebrocortical Neurons. Journal Of Neurochemistry 2000, 74: 134-142. PMID: 10617114, DOI: 10.1046/j.1471-4159.2000.0740134.x.Peer-Reviewed Original ResearchConceptsCerebrocortical neuronsNeuronal deathNeuronal apoptosisIncubation of neuronsNMDA receptor activationCaspase-3Time-dependent increaseCentral neuronsNMDA stimulationExcessive activationGlutamate receptorsMild insultReceptor activationCaspase-3-like proteasesDouble labelingNeurodegenerative diseasesNMDANeuronsApoptotic cellsConcordant resultsApoptosisPossible activationActivation of caspasesInsultAffinity labeling technique
1999
Attenuation of NMDA Receptor Activity and Neurotoxicity by Nitroxyl Anion, NO−
Kim W, Choi Y, Rayudu P, Das P, Asaad W, Arnelle D, Stamler J, Lipton S. Attenuation of NMDA Receptor Activity and Neurotoxicity by Nitroxyl Anion, NO−. Neuron 1999, 24: 461-469. PMID: 10571239, DOI: 10.1016/s0896-6273(00)80859-4.Peer-Reviewed Original Research
1998
■ REVIEW : Excitotoxicity, Free Radicals, Necrosis, and Apoptosis
Lipton S, Nicotera P. ■ REVIEW : Excitotoxicity, Free Radicals, Necrosis, and Apoptosis. The Neuroscientist 1998, 4: 345-352. DOI: 10.1177/107385849800400516.Peer-Reviewed Original ResearchNitric oxideMajor excitatory neurotransmitterCentral nervous systemFailure of neuronsFree radicalsNeuronal cell culturesActivation of proteasesNeuronal injuryAIDS dementiaNeuronal necrosisInitial insultExcitatory neurotransmitterNervous systemApoptotic death programAlzheimer's diseaseHuntington's diseaseDiseaseInsultExcitotoxicityMitochondrial membrane potentialNecrosisCell deathDeath programNeuronsApoptosis
1996
Neuronal apoptosis versus necrosis induced by glutamate or free radicals
Nicotera P, Ankarcrona M, Bonfoco E, Orrenius S, Lipton S. Neuronal apoptosis versus necrosis induced by glutamate or free radicals. Apoptosis 1996, 1: 5-10. DOI: 10.1007/bf00142073.Peer-Reviewed Original ResearchMajor excitatory neurotransmitterCentral nervous systemFailure of neuronsFree radicalsNeuronal cell culturesNeuronal injuryExcitatory neurotransmitterNeuronal apoptosisNervous systemApoptotic death programNitric oxideInsultInjuryCell deathDeath programNeuronsGlutamateCell culturesApoptosisExcitotoxinsIschemiaEnergy depletionNecrosisNeurotransmittersProgression
1995
Transcriptional or translational inhibition blocks low dose NMDA-mediated cell death
Dreyer E, Zhang D, Lipton S. Transcriptional or translational inhibition blocks low dose NMDA-mediated cell death. Neuroreport 1995, 6: 942-944. PMID: 7612888, DOI: 10.1097/00001756-199504190-00029.Peer-Reviewed Original Research
1992
chapter 26 Molecular Basis for the Potential Use of NMDA Receptor Open-Channel Blockers in the Treatment of Cerebral Ischemia and Other Brain Insults
Lipton S, Heinemann S. chapter 26 Molecular Basis for the Potential Use of NMDA Receptor Open-Channel Blockers in the Treatment of Cerebral Ischemia and Other Brain Insults. 1992, 470-478. DOI: 10.1016/b978-0-7216-9428-3.50031-7.Peer-Reviewed Original Research