1992
Memantine prevents HIV coat protein-induced neuronal injury in vitro.
Lipton S. Memantine prevents HIV coat protein-induced neuronal injury in vitro. Neurology 1992, 42: 1403-5. PMID: 1620355, DOI: 10.1212/wnl.42.7.1403.Peer-Reviewed Original ResearchConceptsNeuronal injuryNeuronal damageHIV-1 coat protein gp120Cognitive/motor complexRat retinal ganglion cellsN-methyl-D-aspartate receptorsHuman immunodeficiency virusPossible protective effectNMDA receptor-operated ion channelsRetinal ganglion cellsReceptor-operated ion channelsMicroM memantineNeurologic deficitsImmunodeficiency virusGanglion cellsNMDA antagonistsProtective effectProtein gp120Therapeutic potentialGp120InjuryMemantineMotor complexConcurrent activationIon channels
1991
Synergistic effects of HIV coat protein and NMDA receptor-mediated neurotoxicity
Lipton S, Sucher N, Kaiser P, Dreyer E. Synergistic effects of HIV coat protein and NMDA receptor-mediated neurotoxicity. Neuron 1991, 7: 111-118. PMID: 1676893, DOI: 10.1016/0896-6273(91)90079-f.Peer-Reviewed Original ResearchConceptsNMDA receptor-mediated neurotoxicityHIV-1 coat protein gp120Whole-cell patch-clamp recordingsHIV coat proteinRat retinal culturesSubsequent neuronal damagePatch-clamp recordingsGlutamate pyruvate transaminaseNeuronal injuryNeuronal damageEndogenous glutamateGanglion cellsNMDA antagonistsProtein gp120Low picomolar concentrationsRetinal culturesGp120NeurotoxicityComplete protectionMinute increasePicomolar concentrationsGlutamateInjuryAntagonistTransaminase