2021
α-Synuclein Oligomers Induce Glutamate Release from Astrocytes and Excessive Extrasynaptic NMDAR Activity in Neurons, Thus Contributing to Synapse Loss
Trudler D, Sanz-Blasco S, Eisele Y, Ghatak S, Bodhinathan K, Akhtar M, Lynch W, Piña-Crespo J, Talantova M, Kelly J, Lipton S. α-Synuclein Oligomers Induce Glutamate Release from Astrocytes and Excessive Extrasynaptic NMDAR Activity in Neurons, Thus Contributing to Synapse Loss. Journal Of Neuroscience 2021, 41: 2264-2273. PMID: 33483428, PMCID: PMC8018774, DOI: 10.1523/jneurosci.1871-20.2020.Peer-Reviewed Original ResearchConceptsLewy body dementiaExtrasynaptic NMDA receptorsSynaptic damageParkinson's diseaseNeuronal lossLewy bodiesNMDAR activityDisease progressionΑSyn oligomersPotential disease-modifying interventionsNeurodegenerative diseasesΑ-synucleinExtrasynaptic NMDAR activitySynaptic NMDAR activityDisease-modifying interventionsPatch-clamp recordingsMajor neuropathological characteristicsSynaptic lossAstrocytic glutamateGlutamate releaseSynapse lossSpine lossExtrasynaptic NMDARsFemale miceHippocampal slices
1994
Neuronal Injury Associated with HIV-1 and Potential Treatment with Calcium-Channel and NMDA Antagonists
Lipton S. Neuronal Injury Associated with HIV-1 and Potential Treatment with Calcium-Channel and NMDA Antagonists. Developmental Neuroscience 1994, 16: 145-151. PMID: 7705221, DOI: 10.1159/000112101.Peer-Reviewed Original ResearchConceptsNMDA antagonistsHIV-1HIV-1 envelope protein gp120Existence of HIVBrains of patientsCalcium channel antagonistsVoltage-dependent Ca2Receptor-operated channelsFuture pharmacological interventionsFinal common pathwayAmyotrophic lateral sclerosisEnvelope protein gp120Platelet-activating factorDemise of neuronsInjury AssociatedAIDS dementiaNeuronal injuryGlutamate reuptakeNeurological manifestationsGlutamate releaseImmunodeficiency syndromeChannel antagonistsPharmacological interventionsProtein gp120Lateral sclerosis