2006
HIV-1 coreceptors CCR5 and CXCR4 both mediate neuronal cell death but CCR5 paradoxically can also contribute to protection
Kaul M, Ma Q, Medders K, Desai M, Lipton S. HIV-1 coreceptors CCR5 and CXCR4 both mediate neuronal cell death but CCR5 paradoxically can also contribute to protection. Cell Death & Differentiation 2006, 14: 296-305. PMID: 16841089, DOI: 10.1038/sj.cdd.4402006.Peer-Reviewed Original ResearchConceptsHuman immunodeficiency virus-1Neuronal cell deathStromal cell-derived factor-1HIV-1 envelope glycoprotein gp120Cell-derived factor-1Cell deathHIV-1 coreceptor CCR5Chemokine receptor CCR5Immunodeficiency virus-1Brain-derived cellsEnvelope glycoprotein gp120Intracellular free Ca2Gp120 neurotoxicityCCR5 ligandsHIV coreceptorsP38 mitogen-activated protein kinaseCCR5 agonistsNeuroprotective pathwaysReceptor CCR5Heterologous desensitizationCoreceptor CCR5CXCR4 agonistCCR5Glial culturesGlycoprotein gp120
1992
Requirement for macrophages in neuronal injury induced by HIV envelope protein gp120
Lipton S. Requirement for macrophages in neuronal injury induced by HIV envelope protein gp120. Neuroreport 1992, 3: 913-915. PMID: 1421098, DOI: 10.1097/00001756-199210000-00023.Peer-Reviewed Original ResearchConceptsHIV envelope protein gp120Retinal ganglion cellsEnvelope protein gp120Neuronal injuryGanglion cellsGlial cellsProtein gp120N-methyl-D-aspartate antagonistsMixed neuronal-glial culturesRetinal ganglion cell neuronsNeuronal-glial culturesGanglion cell neuronsActivation of macrophagesPresence of macrophagesPM gp120Like damageGlial culturesCell neuronsGp120Early increaseFree calciumPostnatal retinaMacrophagesInjurious effectsNeurons