2008
Clinically Tolerated Strategies for NMDA Receptor Antagonism
Vincent Chen H, Zhang D, Lipton S. Clinically Tolerated Strategies for NMDA Receptor Antagonism. The Receptors 2008, 327-361. DOI: 10.1007/978-1-59745-055-3_8.Peer-Reviewed Original ResearchExcessive NMDAR activityNMDAR activityClinical trialsGlutamate receptorsSide effectsNeurologic disordersNervous systemAcute hypoxic-ischemic brain injuryGeneralized inhibitionAlzheimer's diseaseSecond-generation memantine derivativesHypoxic-ischemic brain injuryPhase 3 clinical trialsExcessive NMDAR activationSevere neuropathic painExcitatory amino acidsGlutamate-mediated neurotoxicityGlutamate receptor subtypesChronic neurodegenerative diseasesSystemic side effectsMajor excitatory transmitterNormal functionNMDA receptor antagonismGreater neuroprotective propertiesCentral nervous system
2007
CHAPTER 25 Functional Characterization of Neurons
McKerchner S, Talantova M, Lipton S. CHAPTER 25 Functional Characterization of Neurons. 2007, 373-386. DOI: 10.1016/b978-012370465-8/50030-2.Peer-Reviewed Original ResearchCentral nervous systemAmyotrophic lateral sclerosisJuvenile-onset diseaseStem cell therapyNeuronal damageCurative treatmentElectrophysiological criteriaMacular degenerationLysosomal storage diseaseParkinson's diseaseLateral sclerosisOnset diseaseNervous systemAlzheimer's diseaseDiseaseCell therapySuch pathologyHuntington's diseaseStorage diseaseEarly childhoodTotal absenceLabeling cellsSclerosisTherapyInjuryNeuroinflammation and Excitotoxicity in Neurobiology of HIV-1 Infection and AIDS: Targets for Neuroprotection
Kaul M, Lipton S. Neuroinflammation and Excitotoxicity in Neurobiology of HIV-1 Infection and AIDS: Targets for Neuroprotection. 2007, 281-308. DOI: 10.1007/978-0-387-70830-0_13.Peer-Reviewed Original ResearchHuman immunodeficiency virus-1Central nervous systemMild behavioral abnormalitiesHIV-1 infectionImmune competent cellsImmunodeficiency virus-1Persistent health problemsFrank dementiaImmunodeficiency syndromeMotor dysfunctionInflammatory responseNeurological problemsParticular macrophagesBehavioral abnormalitiesNervous systemHealth problemsVirus 1InfectionBrainCell typesNeuroinflammationExcitotoxicityNeuroprotectionDysfunctionSyndrome
2005
HIV-1 infection and AIDS: consequences for the central nervous system
Kaul M, Zheng J, Okamoto S, Gendelman H, Lipton S. HIV-1 infection and AIDS: consequences for the central nervous system. Cell Death & Differentiation 2005, 12: 878-892. PMID: 15832177, DOI: 10.1038/sj.cdd.4401623.Peer-Reviewed Original ResearchMeSH KeywordsAcquired Immunodeficiency SyndromeAIDS Dementia ComplexAnimalsAntiretroviral Therapy, Highly ActiveApoptosisApoptosis Regulatory ProteinsBrainChemokinesForecastingHIV Envelope Protein gp120HIV-1HumansMembrane GlycoproteinsMicrogliaNerve DegenerationNeuronsReceptors, ChemokineSignal TransductionStem CellsTNF-Related Apoptosis-Inducing LigandTumor Necrosis Factor-alphaConceptsHuman immunodeficiency virus-1Glutamate receptor-mediated excitotoxicityReceptor-mediated excitotoxicityHIV-1 infectionImmune competent cellsExtracellular matrix-degrading enzymesImmunodeficiency virus-1Central nervous systemFuture therapeutic interventionsMatrix-degrading enzymesFrank dementiaInflammatory mediatorsNeuronal damageMotor dysfunctionChemokine receptorsGlial functionDegenerative mechanismsNeurological problemsParticular macrophagesBehavioral abnormalitiesNervous systemTherapeutic interventionsNeuropathological responsesVirus 1InfectionExperimental and potential future therapeutic approaches for HIV-1 associated dementia targeting receptors for chemokines, glutamate and erythropoietin
Kaul M, Lipton S. Experimental and potential future therapeutic approaches for HIV-1 associated dementia targeting receptors for chemokines, glutamate and erythropoietin. Neurotoxicity Research 2005, 8: 167-186. PMID: 16260394, DOI: 10.1007/bf03033828.Peer-Reviewed Original ResearchConceptsHuman immunodeficiency virus-1Central nervous systemGlutamate receptor-mediated excitotoxicityHIV-1 infection resultsPotential future therapeutic approachesReceptor-mediated excitotoxicityImmune competent cellsExtracellular matrix-degrading enzymesFuture therapeutic approachesImmunodeficiency virus-1Future therapeutic strategiesMatrix-degrading enzymesFrank dementiaInflammatory mediatorsNeuronal damageMotor dysfunctionChemokine receptorsEffective therapyGlial functionPathologic mechanismsTherapeutic approachesNeurological problemsTherapeutic strategiesInfection resultsParticular macrophages
2000
How Are Neuronal Genes Expressed in Neurons? Regulation of NMDA Receptor Subunit Type 1 Gene as a Model
Okamoto S, Sherman K, Lipton S. How Are Neuronal Genes Expressed in Neurons? Regulation of NMDA Receptor Subunit Type 1 Gene as a Model. 2000, 355-360. DOI: 10.1007/978-4-431-66973-9_47.Peer-Reviewed Original ResearchType 1 geneRegulation of expressionGene regulationNeuronal genesEssential subunitDifferentiation proceedsTranscriptional levelFunctional NMDA receptorsNeuronal differentiationGenesVariety of moleculesNR1 geneNeuronal functionRegulationCentral nervous systemNR1ExpressionSynaptic responsesNMDA receptorsNeuronal activityNervous systemSubunitsNeuronsDifferentiationBest model
1998
■ REVIEW : Excitotoxicity, Free Radicals, Necrosis, and Apoptosis
Lipton S, Nicotera P. ■ REVIEW : Excitotoxicity, Free Radicals, Necrosis, and Apoptosis. The Neuroscientist 1998, 4: 345-352. DOI: 10.1177/107385849800400516.Peer-Reviewed Original ResearchNitric oxideMajor excitatory neurotransmitterCentral nervous systemFailure of neuronsFree radicalsNeuronal cell culturesActivation of proteasesNeuronal injuryAIDS dementiaNeuronal necrosisInitial insultExcitatory neurotransmitterNervous systemApoptotic death programAlzheimer's diseaseHuntington's diseaseDiseaseInsultExcitotoxicityMitochondrial membrane potentialNecrosisCell deathDeath programNeuronsApoptosisNeuroprotective versus neurodestructive effects of NO‐related species
Lipton S, Choi Y, Sucher N, Chen H. Neuroprotective versus neurodestructive effects of NO‐related species. BioFactors 1998, 8: 33-40. PMID: 9699006, DOI: 10.1002/biof.5520080107.Peer-Reviewed Original ResearchConceptsNMDA receptorsCentral nervous systemNMDA receptor subunitsNeuronal injuryNeurodestructive effectsNervous systemRedox modulationReceptor subunitsNitric oxideExcessive Ca2Protective actionChannel activitySuperoxide anionNO groupReceptorsS-nitrosylationGroupDiverse tissuesNeuroprotectionInjuryBrain
1997
Neuropathogenesis of acquired immunodeficiency syndrome dementia
Lipton S. Neuropathogenesis of acquired immunodeficiency syndrome dementia. Current Opinion In Neurology 1997, 10: 247-253. PMID: 9229134, DOI: 10.1097/00019052-199706000-00014.Peer-Reviewed Original ResearchConceptsImmunodeficiency syndrome (AIDS) dementiaImmunodeficiency syndrome (AIDS) patientsPotential new treatmentCentral nervous systemDevelopment of therapiesAntiretroviral therapyNeuronal injuryBrain macrophagesImmunodeficiency syndromeAntiretroviral drugsNeuronal deathHuman immunodeficiencySurrogate markerClinical trialsSyndrome patientsDirect infectionCerebrospinal fluidNervous systemPast year progressNew treatmentsViral productsTherapyDementiaOne-thirdFurther characterization
1996
Neuronal apoptosis versus necrosis induced by glutamate or free radicals
Nicotera P, Ankarcrona M, Bonfoco E, Orrenius S, Lipton S. Neuronal apoptosis versus necrosis induced by glutamate or free radicals. Apoptosis 1996, 1: 5-10. DOI: 10.1007/bf00142073.Peer-Reviewed Original ResearchMajor excitatory neurotransmitterCentral nervous systemFailure of neuronsFree radicalsNeuronal cell culturesNeuronal injuryExcitatory neurotransmitterNeuronal apoptosisNervous systemApoptotic death programNitric oxideInsultInjuryCell deathDeath programNeuronsGlutamateCell culturesApoptosisExcitotoxinsIschemiaEnergy depletionNecrosisNeurotransmittersProgression
1995
An astrocytic binding site for neuronal Thy-1 and its effect on neurite outgrowth.
Dreyer E, Leifer D, Heng J, McConnell J, Gorla M, Levin L, Barnstable C, Lipton S. An astrocytic binding site for neuronal Thy-1 and its effect on neurite outgrowth. Proceedings Of The National Academy Of Sciences Of The United States Of America 1995, 92: 11195-11199. PMID: 7479964, PMCID: PMC40598, DOI: 10.1073/pnas.92.24.11195.Peer-Reviewed Original ResearchConceptsNeurite outgrowthThy-1 functionsNeuronal Thy-1Thy-1Abundant glycoproteinMammalian neuronsNervous systemAnti-idiotype monoclonal antibodyCentral nervous system neuronsMonoclonal antibodiesBinding sitesCentral nervous systemAnti-idiotype antibodiesCertain monoclonal antibodiesBinding assaysCompetitive binding assaysProteinOutgrowthSystem neuronsDendritic developmentAntibodiesNeuronsSitesGlycoproteinCells
1994
Chapter 29 Nitric oxide in the central nervous system
Lipton S, Singel D, Stamler J. Chapter 29 Nitric oxide in the central nervous system. Progress In Brain Research 1994, 103: 359-364. PMID: 7886218, DOI: 10.1016/s0079-6123(08)61149-8.Peer-Reviewed Original ResearchConceptsS-nitrosylationProtein S-nitrosylationNMDA receptorsLevels of thiolsPlasma membraneNitric oxideRedox milieuRelated congenersNMDA receptor activityCentral nervous systemNovel therapeutic strategiesRedox stateFormation of peroxynitriteCell functionAIDS dementiaNeuroprotective pathwaysCerebral ischemiaFocal ischemiaExcessive activationRecent findingsTherapeutic strategiesNervous systemNeurological disordersReceptor activityBiological systems
1989
Growth Factors for Neuronal Survival and Process Regeneration: Implications in the Mammalian Central Nervous System
Lipton S. Growth Factors for Neuronal Survival and Process Regeneration: Implications in the Mammalian Central Nervous System. JAMA Neurology 1989, 46: 1241-1248. PMID: 2573331, DOI: 10.1001/archneur.1989.00520470113038.Peer-Reviewed Original ResearchConceptsNeuronal survivalClinical neurologistsMammalian central nervous systemCentral nervous systemPossible therapeutic approachesPotential clinical implicationsImmunodeficiency syndromeAxonal regenerationNeuronal transplantationNeurologic disordersTherapeutic approachesModulatory agentsNervous systemAlzheimer's diseaseClinical implicationsMammalian brainNerve growthNeuronal processesGrowth factorNeurologistsNumber of substancesDiseaseNeuronsProcess regenerationSurvivalGABA-activated single channel currents in outside-out membrane patches from rat retinal ganglion cells
Lipton S. GABA-activated single channel currents in outside-out membrane patches from rat retinal ganglion cells. Visual Neuroscience 1989, 3: 275-279. PMID: 2487107, DOI: 10.1017/s0952523800010026.Peer-Reviewed Original ResearchConceptsRetinal ganglion cellsGamma-aminobutyric acidGanglion cellsWhole-cell currentsMammalian retinal ganglion cellsRat retinal ganglion cellsLarge whole-cell currentsMammalian central nervous systemWhole-cell recordingsCentral nervous systemPatch-clamp methodInhibitory transmitterWhole-cell responsesNervous systemCell-free patchesNervous tissueGABAA channelsRapid rundownDesensitization kineticsSingle-channel recordingsChannel currentsSingle-channel currentsExcised patch configurationsSingle-channel eventsUnitary conductance
1988
Acidic fibroblast growth factor enhances regeneration of processes by postnatal mammalian retinal ganglion cells in culture.
Lipton S, Wagner J, Madison R, D'Amore P. Acidic fibroblast growth factor enhances regeneration of processes by postnatal mammalian retinal ganglion cells in culture. Proceedings Of The National Academy Of Sciences Of The United States Of America 1988, 85: 2388-2392. PMID: 3353388, PMCID: PMC279998, DOI: 10.1073/pnas.85.7.2388.Peer-Reviewed Original ResearchConceptsRat retinal ganglion cellsBasic fibroblast growth factorAcidic fibroblast growth factorRetinal ganglion cellsFibroblast growth factorGlial cellsGrowth factorProcess outgrowthGanglion cellsPostnatal rat retinal ganglion cellsMammalian retinal ganglion cellsOutgrowth of processesGlial fibrillary acidic proteinEffect of aFGFMammalian central nervous systemMammalian central neuronsRegeneration of processesFibrillary acidic proteinCentral nervous systemPeptide growth factorsRGC survivalHumoral effectsHeparin-like moleculesCentral neuronsAddition of heparin
1987
Bursting of calcium-activated cation-selective channels is associated with neurite regeneration in a mammalian central neuron
Lipton S. Bursting of calcium-activated cation-selective channels is associated with neurite regeneration in a mammalian central neuron. Neuroscience Letters 1987, 82: 21-28. PMID: 2447529, DOI: 10.1016/0304-3940(87)90165-0.Peer-Reviewed Original ResearchConceptsPostnatal rat retinal ganglion cellsNeurite regenerationRat retinal ganglion cellsMammalian central nervous systemRetinal ganglion cellsMammalian central neuronsCentral nervous systemPatch-clamp techniqueCell-attached patchesGanglion cellsCentral neuronsNervous systemIntracellular Ca2Internal calciumCation-selective channelsSingle-channel currentsNeuronsProlonged periodCellsNeural nicotinic acetylcholine responses in solitary mammalian retinal ganglion cells
Lipton S, Aizenman E, Loring R. Neural nicotinic acetylcholine responses in solitary mammalian retinal ganglion cells. Pflügers Archiv - European Journal Of Physiology 1987, 410: 37-43. PMID: 3684508, DOI: 10.1007/bf00581893.Peer-Reviewed Original ResearchConceptsRetinal ganglion cellsGanglion cellsWhole-cell recordingsAcetylcholine responseNicotinic responsesNervous systemMammalian retinal ganglion cellsRat retinal ganglion cellsNicotinic channelsAutonomic ganglion cellsDihydro-β-erythroidineNicotinic receptor antagonistAcetylcholine-induced currentsPeripheral nervous systemNicotinic acetylcholine responsesAgonist-induced currentsCentral nervous systemPatch-clamp techniqueCholinergic responsesReceptor antagonistCentral neuronsToxin FD-tubocurarineNicotinic natureΑ-bungarotoxin
1986
Association of Lupuslike Anticoagulant and Nonvasculitic Cerebral Infarction
Tabachnik-Schor N, Lipton S. Association of Lupuslike Anticoagulant and Nonvasculitic Cerebral Infarction. JAMA Neurology 1986, 43: 851-852. PMID: 3089204, DOI: 10.1001/archneur.1986.00520080089033.Peer-Reviewed Original Research
1984
Candidal infection in the central nervous system
Lipton S, Hickey W, Morris J, Loscalzo J. Candidal infection in the central nervous system. The American Journal Of Medicine 1984, 76: 101-108. PMID: 6691350, DOI: 10.1016/0002-9343(84)90757-5.Peer-Reviewed Original ResearchConceptsMycotic aneurysmCandidal infectionAntemortem diagnosisAmphotericin BCentral nervous system involvementCentral nervous system candidiasisPercent of patientsCerebrospinal fluid examinationNervous system involvementCentral nervous systemCerebral mycosisInadequate eradicationMeningeal formCerebral involvementParenchymal infectionFluid examinationUnrecognized lesionsDrug therapySystem involvementCerebral vesselsFungus ballRisk factorsDisease entityEarly diagnosisSignificant incidence