Prospects for clinically tolerated NMDA antagonists: open-channel blockers and alternative redox states of nitric oxide
Lipton S. Prospects for clinically tolerated NMDA antagonists: open-channel blockers and alternative redox states of nitric oxide. Trends In Neurosciences 1993, 16: 527-532. PMID: 7509524, DOI: 10.1016/0166-2236(93)90198-u.Peer-Reviewed Original ResearchConceptsExcitatory amino acid receptorsAmino acid receptorsAcid receptorsN-methyl-D-aspartate receptorsChronic neurological diseaseNMDA receptor antagonistNMDA receptor activityOpen channel blockOpen channel blockerReceptor antagonistNMDA antagonistsAnimal modelsNeurotoxic damageNeurological diseasesReceptor activityClinical useNitric oxideAntagonistReceptorsAlternative redox statesBlockersDiseaseA redox-based mechanism for the neuroprotective and neurodestructive effects of nitric oxide and related nitroso-compounds
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