Adjunct Faculty
Adjunct faculty typically have an academic or research appointment at another institution and contribute or collaborate with one or more School of Medicine faculty members or programs.
Adjunct rank detailsStephanie Eisenbarth, MD, PhD
Associate Professor AdjunctDownloadHi-Res Photo
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Titles
Associate Professor Adjunct
Biography
Dr. Eisenbarth’s laboratory focuses on how dendritic cells, B cells and T cells interact to induce tailored adaptive immune responses. The work spans how this triad is operational in the spleen to transfused red blood cells (RBCs), in the lung to aeroallergens, and in the gut to food allergens, utilizing both mouse models and human samples.
Last Updated on February 06, 2024.
Appointments
Laboratory Medicine
Associate Professor AdjunctPrimary
Other Departments & Organizations
Education & Training
- Postdoctoral Fellow
- Yale University (2010)
- Resident
- Yale New Haven Hospital (2008)
- MD
- Yale School of Medicine (2005)
- PhD
- Yale University (2003)
- BA
- Bryn Mawr College (1996)
Research
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Overview
Medical Research Interests
Allergy and Immunology; Asthma; Blood Group Incompatibility; Food Hypersensitivity; Immune System Diseases
ORCID
0000-0002-1244-208X
Research at a Glance
Yale Co-Authors
Frequent collaborators of Stephanie Eisenbarth's published research.
Research Interests
Research topics Stephanie Eisenbarth is interested in exploring.
Elise Liu, MD, PhD
Laura Rose Hoyt
Shuting Chen
Christine Dien
Craig B. Wilen, MD, PhD
Hailong Meng, PhD
Food Hypersensitivity
Publications
2025
Sequential class switching generates antigen-specific gut IgA from IgG1 B cells
Siniscalco E, Meng H, Gabernet G, Pacheco G, Saghaei S, Ramirez S, Hills L, Faraji F, Chen S, Yin X, Dien C, Hoyt L, Liu E, Barrett A, Briggs N, Williams A, Shukla V, Crotty S, Wesemann D, Kleinstein S, Craft J, Eisenbarth S. Sequential class switching generates antigen-specific gut IgA from IgG1 B cells. Immunity 2025 PMID: 41253159, DOI: 10.1016/j.immuni.2025.10.022.Peer-Reviewed Original ResearchThis study investigates how gut-specific IgA antibodies are generated from IgG1 B cells through sequential class switching, highlighting a crucial mechanism for designing effective mucosal vaccines.Large language models accurately identify immunosuppression in intensive care unit patients
Guggilla V, Kang M, Bak M, Tran S, Pawlowski A, Nannapaneni P, Rasmussen L, Schneider D, Donnelly H, Agrawal A, Liebovitz D, Misharin A, Budinger G, Wunderink R, Walunas T, Gao C, Hauser A, Peltekian A, Misharin A, Wolfe A, Szabo A, Choudhary A, Ludwig A, Moghadam A, Yeldandi A, Agrawal A, Bharat A, Pawlowski A, Joudi A, Tambe A, Smith-Nunez A, Singer B, Ulrich B, Tran B, Gottardi C, Gao C, Qi C, Pickens C, Schroedl C, Meza D, Schneider D, Garcia D, Ozer E, Gusman E, Shanes E, Leibenguth E, Olson E, Hartmann E, Korth E, Diaz E, Guzman E, Martinez F, Matias G, Budinger G, Donnelly H, Abdala-Valencia H, Sumner J, Sznajder J, Kruser J, Glowala J, Walter J, Rowell J, Arnold J, Coleman J, Lomasney J, Bailey J, Hultquist J, Fiala J, Starren J, Ridge K, Senkow K, Helmin K, Gates K, Simmons L, Pinzon L, Gradone L, Wolfe L, Luo L, Morales-Nebreda L, Rasmussen L, Jain M, Sala M, Schleck M, Ross M, Querrey M, Kang M, Cuttica M, Prickett M, Nadig N, Rhodes N, Chandel N, Markov N, Sporn P, Nannapaneni P, Liu Q, Kadar R, Medernach R, Lorenzo-Redondo R, Kalhan R, Clepp R, Wunderink R, Morimoto R, Grant R, Mylvaganam R, Fenske S, Laurenzo S, Smith S, Han S, Nozick S, Panchamukhi S, Eisenbarth S, Swaminathan S, Russell S, Poor T, Cybulski T, Lombardo T, Walunas T, Bolig T, Stoeger T, Doan T, Rowe T, Guggilla V, Liao W, Luo Y, Sokolenko Y, Yu Z, Lu Z. Large language models accurately identify immunosuppression in intensive care unit patients. Journal Of The American Medical Informatics Association 2025, ocaf141. PMID: 40977378, DOI: 10.1093/jamia/ocaf141.Peer-Reviewed Original ResearchAltmetricConceptsNatural language processing approachNatural language processingF1 scoreData algorithmLanguage modelHeterogeneous typesIntensive care unitIntensive care unit patientsLanguage processingImmunosuppressive conditionsMedication ordersPrimary cohortClinical notesPoor generalizabilityCohort identificationAlgorithmDiagnosis codesValidation cohortHospital admission notesType of immunosuppressionCodeBeth Israel Deaconess Medical CenterImmunosuppressive medication useRobust external validationNorthwestern Memorial HospitalA roadmap for defining “extrafollicular” B cell responses
Eisenbarth S, Batista F, Cyster J, Elsner R, Kelsoe G, Lund F, Pillai S, Sanz I, Shlomchik M, Toellner K, Vinuesa C, Baumgarth N. A roadmap for defining “extrafollicular” B cell responses. Immunity 2025 PMID: 40987283, DOI: 10.1016/j.immuni.2025.08.007.Peer-Reviewed Original ResearchCitationsAltmetricExtrafollicular and Other Non‐Germinal Center B Cell Responses: An Evolutionary Perspective
Flowers E, Siniscalco E, Eisenbarth S. Extrafollicular and Other Non‐Germinal Center B Cell Responses: An Evolutionary Perspective. Immunological Reviews 2025, 334: e70060. PMID: 40938272, DOI: 10.1111/imr.70060.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsGerminal centersHumoral immunityMultiple generaImmunological foundationsVertebrate evolutionAdjacent T cellsB cell responsesB cell proliferationB-cell regionsGC-independent pathwayMammalsT cellsHumoral protectionMechanisms of humoral immunityGC responsePathwayProtective antibodiesOrgan sitesAntibody responseAntigen depositionAntibodiesGenusCysteinyl leukotrienes stimulate gut absorption of food allergens to promote anaphylaxis in mice
Hoyt L, Liu E, Olson E, Jacobsen D, Siniscalco E, Krier-Burris R, Greenfield K, McBride C, Alfajaro M, Amat J, Zhao Z, Xu L, Philip V, Verma A, Fourati S, Senger D, Zhang L, Bunyavanich S, Glass S, Coffey R, Wilen C, Williams A, Eisenbarth S. Cysteinyl leukotrienes stimulate gut absorption of food allergens to promote anaphylaxis in mice. Science 2025, 389: eadp0240. PMID: 40773557, PMCID: PMC12333546, DOI: 10.1126/science.adp0240.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsFood-specific immunoglobulin ESensitivity to anaphylaxisFood-specific IgEResistant C57BL/6 miceFood allergensLife-threatening anaphylaxisStrains of miceGut absorptionOral anaphylaxisSusceptible miceResistant miceC57BL/6 miceCysteinyl leukotrienesAllergen consumptionAllergic sensitizationFood allergyImmunoglobulin EAllergen absorptionAnaphylaxisIntestinal epitheliumMiceIntestinal goblet cellsAllergen transportSynthesis inhibitorGoblet cellsTolerance requires diversity (of antigen presenting cells).
Jacobsen D, Eisenbarth S. Tolerance requires diversity (of antigen presenting cells). Science Immunology 2025, 10: eady4136. PMID: 40315295, DOI: 10.1126/sciimmunol.ady4136.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and Concepts
2024
Dendritic cells in a pinch: Migration during homeostasis.
Olson E, Eisenbarth S. Dendritic cells in a pinch: Migration during homeostasis. Science Immunology 2024, 9: eadt3806. PMID: 39365873, DOI: 10.1126/sciimmunol.adt3806.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsConceptsDendritic cellsScaleable production of highly loaded protein nanoparticles for immune modulation
Caplan M, Baldwin R, Yin X, Grishin A, Eisenbarth S, Sampson H, Bottomly K, Prud’homme R. Scaleable production of highly loaded protein nanoparticles for immune modulation. Communications Materials 2024, 5: 191. DOI: 10.1038/s43246-024-00626-w.Peer-Reviewed Original ResearchCitationsConceptsAdjuvants to antigen-presenting cellsImmune modulationAntigen-presenting cellsMurine immune systemImmune system cellsPeanut-allergic patientsDesensitizer applicationPLG nanoparticlesAntigen deliverySystemic exposurePoly(lactide-co-glycolideBasophil activationClinical investigationAllergic responsesImmune systemSystem cellsProtein antigensClinical applicationDelivery of proteinsE. coli phospholipidsSafety evidenceAntigenProtein nanoparticlesDeliveryCellsIncreased autoreactivity and maturity of EBI2+ antibody-secreting cells from nasal polyps
Bai J, Kato A, Hulse K, Wechsler J, Gujar V, Poposki J, Harmon R, Iwasaki N, Wang B, Huang J, Stevens W, Conley D, Welch K, Kern R, Peters A, Eisenbarth S, Schleimer R, Tan B. Increased autoreactivity and maturity of EBI2+ antibody-secreting cells from nasal polyps. JCI Insight 2024, 9: e177729. PMID: 39253973, PMCID: PMC11385095, DOI: 10.1172/jci.insight.177729.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsAntibody-secreting cellsGene Ontology biological processesSingle-cell RNA-seq analysisApoptosis pathwayNumbers of antibody-secreting cellsAnti-dsDNA IgGPlasma cell differentiationBiological processesCell differentiationNasal polypsGenesMolecular characteristicsNF-kBProliferative cellsMolecular featuresCellsAnti-double-stranded DNAIgG antibody-secreting cellsEBI2B cellsXBP1Recurrent NPElevated numbersDNAIncreased autoreactivityAll roads lead to IgA: Mapping the many pathways of IgA induction in the gut
Siniscalco E, Williams A, Eisenbarth S. All roads lead to IgA: Mapping the many pathways of IgA induction in the gut. Immunological Reviews 2024, 326: 66-82. PMID: 39046160, PMCID: PMC12281416, DOI: 10.1111/imr.13369.Peer-Reviewed Original ResearchCitationsAltmetricConceptsIgA inductionFood allergyFood-specific IgE.Food-specific IgEAntibody isotypesPrevalence of food allergyT cell helpIncreasing prevalence of food allergyRelease of histamineFoodFood antigensB cellsInduce toleranceAdverse reactionsCommensal bacteriaMast cellsIncreased prevalenceGut immunityIgAGutAllergyAntibodiesIsotypeInduction
Academic Achievements & Community Involvement
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Activities
activity American Society for Clinical Investigation
04/17/2020 - PresentProfessional OrganizationsMember
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News
- February 26, 2024
Elise Liu Receives 2024 AAAAI Foundation Faculty Development Award
- May 08, 2023
Liu Wins ASCI Emerging-Generation Award
- October 28, 2022
Meet Yale Allergy & Immunology: Jake Kuster, MD, and Elise Liu, MD
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