Scott Woods, MD
Elizabeth Mears and House Jameson Professor of PsychiatryCards
Appointments
Psychiatry
Primary
Child Study Center
Secondary
Contact Info
About
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Titles
Elizabeth Mears and House Jameson Professor of Psychiatry
Biography
Dr. Woods assesses young people at risk for psychosis through his PRIME Clinic, which also offers studies aiming to improve treatment for current symptoms and preventing progression.
Last Updated on April 07, 2025.
Appointments
Psychiatry
ProfessorPrimaryChild Study Center
ProfessorSecondary
Other Departments & Organizations
- Adult Psychiatry
- All Institutions
- Child Study Center
- Connecticut Mental Health Center
- MR Core
- PRIME Psychosis Prodrome Research Clinic
- Psychiatry
- Yale Medicine
- Yale New Haven Health System
- Yale Ventures
Education & Training
- Resident
- Massachusetts General Hospital (1984)
- MD
- Baylor College of Medicine (1978)
Research
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Overview
Predictors and Mechanisms of Conversion to Psychosis (MH082022)
Aspirin vs placebo for the psychosis prodrome
D-serine for the psychosis prodrome (MH074356)
Dutetrabenzine for tardive dyskinesia
Huperzine for cognitive enhancement in schizophrenia (MH083436)
Medical Research Interests
Adolescent Psychiatry; Prodromal Symptoms; Psychiatry; Psychotic Disorders
ORCID
0000-0002-3103-5228
Research at a Glance
Yale Co-Authors
Frequent collaborators of Scott Woods's published research.
Publications Timeline
A big-picture view of Scott Woods's research output by year.
Research Interests
Research topics Scott Woods is interested in exploring.
Tyrone Cannon
Albert Powers, MD, PhD
Philip Corlett, PhD
Godfrey Pearlson, MA, MBBS
Zailyn Tamayo
Emily Farina, PhD
93Publications
546Citations
Psychotic Disorders
Prodromal Symptoms
Publications
2026
Neighborhood social fragmentation and cerebello-thalamo-cortical connectivity in youth at clinical high-risk for psychosis and healthy comparisons
Ku B, Arrant E, Addington J, Bearden C, Cadenhead K, Cannon T, Carrion R, Keshavan M, Mathalon D, Stone W, Woods S, Walker E, Perkins D, Cao H. Neighborhood social fragmentation and cerebello-thalamo-cortical connectivity in youth at clinical high-risk for psychosis and healthy comparisons. Brain And Environment 2026, 5: 100016. PMID: 41907310, PMCID: PMC13030900, DOI: 10.1016/j.braen.2026.100016.Peer-Reviewed Original ResearchAltmetricConceptsNeighbourhood social fragmentationClinical high riskHealthy comparisonCHR-PSocial fragmentationPsychosis riskNorth American Prodrome Longitudinal Study Phase 2Functional connectivity dataPredictive coding frameworkCerebello-thalamo-cortical connectionsHC youthPsychosisIndividual povertyMaladaptive processesBrain's abilitySocial tiesBelief updatingEducational attainmentSocial worldConnectivity dataYouthStudy phase 2Early interventionNeighborhoodSocial environmentThe Utility of Negative Symptoms in Predicting Transition to Psychosis Among Individuals at Clinical High Risk
Arnovitz M, Cornblatt B, Auther A, McLaughlin D, Addington J, Bearden C, Cadenhead K, Cannon T, Keshavan M, Mathalon D, Perkins D, Stone W, Tsuang M, Walker E, Woods S, Kane J, Carrión R. The Utility of Negative Symptoms in Predicting Transition to Psychosis Among Individuals at Clinical High Risk. Schizophrenia Bulletin 2026, 52: sbaf244. PMID: 41863384, PMCID: PMC13005126, DOI: 10.1093/schbul/sbaf244.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsConceptsNegative symptomsClinical high riskDepressive symptomsCHR-NTCHR-PSymptom modelNorth American Prodrome Longitudinal StudyScale of Prodromal SymptomsHealthy controlsCalgary Depression ScaleExpressive negative symptomsNegative symptom severitySocial anhedoniaCHR-TSymptom severityPsychosisIdeational richnessProdromal symptomsDepression ScaleLongitudinal studyHigh riskData support considerationSymptomsHigh-risk individualsFollow-upVisual P300 and risk for psychosis onset in youth at clinical high-risk
Hamilton H, Roach B, Nicholas S, Dembo R, Bachman P, Belger A, Carrion R, Duncan E, Johannesen J, Light G, Niznikiewicz M, Addington J, Bearden C, Cadenhead K, Perkins D, Walker E, Woods S, Cannon T, Mathalon D. Visual P300 and risk for psychosis onset in youth at clinical high-risk. Biological Psychiatry 2026 PMID: 41771336, DOI: 10.1016/j.biopsych.2026.02.013.Peer-Reviewed Original ResearchCitationsAltmetricConceptsClinical high riskHealthy comparisonEvent-related potentialsCHR individualsPsychosis onsetP3b deficitsPsychosis conversionNorth American Prodrome Longitudinal StudyVisual P300 event-related potentialsThree-stimulus visual oddball taskPathogenesis of psychosisPrediction of psychosis onsetP300 event-related potentialVisual oddball taskInfrequent target stimuliAssociated with future outcomesCHR participantsNovelty P3aNovel stimuliNAPLS-2Target stimuliSymptom severityOddball taskP300 amplitudePsychosisComputational phenotypes underlying effort-based decision-making and negative symptoms in a transdiagnostic severe mental illness sample
Luther L, Cooper J, Treadway M, Knippenberg A, Walker E, Gold J, Waltz J, Schiffman J, Ellman L, Mittal V, Zinbarg R, Silverstein S, Corlett P, Powers A, Woods S, Allen D, Lahti A, Strauss G. Computational phenotypes underlying effort-based decision-making and negative symptoms in a transdiagnostic severe mental illness sample. Molecular Psychiatry 2026, 1-11. PMID: 41691110, DOI: 10.1038/s41380-026-03474-x.Peer-Reviewed Original ResearchAltmetricConceptsEffort-based decision-makingNegative symptomsReward magnitudeDepressive disorderNegative symptom measuresClinical high riskFirst-episode psychosisMentally ill sampleMultiple psychiatric diagnosesReward taskSymptom measuresBipolar disorderNeuropsychological testsEffort expenditurePsychiatric diagnosisIll sampleDiagnostic groupsSubjective valueHealthy control groupCognitive impairmentHC groupBias modelRewardDisordersPsychosisContributions of regional cortical thickness and surface area to cognitive functioning in psychosis-risk
Guest R, Addington J, Bearden C, Cadenhead K, Cornblatt B, Mathalon D, Perkins D, Tsuang M, Woods S, Cannon T, Keshavan M, Stone W, Walker E. Contributions of regional cortical thickness and surface area to cognitive functioning in psychosis-risk. Schizophrenia Research 2026, 290: 98-105. PMID: 41671768, DOI: 10.1016/j.schres.2026.02.004.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsConceptsWechsler Abbreviated ScaleHealthy control participantsCHR-PCognitive functionBetter cognitive functionCortical thicknessControl participantsWechsler Abbreviated Scale of IntelligenceNorth American Prodrome Longitudinal StudyEarly stages of psychosisCHR-P samplesStages of psychosisClinical high riskFull-scale IQAssociated with better cognitive functionStructural MRI scansAberrant neurodevelopmental processesScale of IntelligenceRegional cortical thicknessPsychosis-riskOnset of illnessCognitive deficitsCHR-P.Cortical substratesFrontoparietal regions
2025
Reduced interpersonal head synchrony in youth at clinical high risk for psychosis
Lozano-Goupil J, Pokorny V, Schiffman J, Silverstein S, Gold J, Waltz J, Ellman L, Strauss G, Walker E, Powers A, Corlett P, Woods S, Mittal V. Reduced interpersonal head synchrony in youth at clinical high risk for psychosis. Psychological Medicine 2025, 55: e387. PMID: 41457934, DOI: 10.1017/s0033291725102754.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsClinical high riskClinical high-risk participantsHealthy controlsHigh riskClinical high-risk groupStrength of synchronyClinical high-risk individualsTemporal alignmentPsychosis-risk statesGroup differencesClinical symptomsAt-risk populationsNo significant group differencesNegative symptomsPositive symptomsImpaired social functioningVideo analysis toolPotential biomarkersSignificant group differencesSocial anhedoniaSymptomsShort video recordingsClinical InterviewNonverbal synchronySocial functioningTheta Oscillations Assessed From a Passive Auditory Oddball Paradigm in Individuals at Clinical High-Risk for Psychosis and Healthy Control Individuals: Associations with Clinical Outcomes and Mismatch Negativity
Hua J, Roach B, Hamilton H, Bachman P, Belger A, Carrión R, Duncan E, Johannesen J, Light G, Niznikiewicz M, Addington J, Bearden C, Cadenhead K, Perkins D, Stone W, Walker E, Woods S, Cannon T, Mathalon D. Theta Oscillations Assessed From a Passive Auditory Oddball Paradigm in Individuals at Clinical High-Risk for Psychosis and Healthy Control Individuals: Associations with Clinical Outcomes and Mismatch Negativity. Biological Psychiatry Global Open Science 2025, 6: 100664. PMID: 41646831, PMCID: PMC12870832, DOI: 10.1016/j.bpsgos.2025.100664.Peer-Reviewed Original ResearchCitationsConceptsCHR-CInter-trial phase coherenceAuditory oddball paradigmHealthy controlsClinical high riskCHR-PMismatch negativityCHR-NCNorth American Prodrome Longitudinal Study 2High riskTheta oscillationsClinical outcomesGeneration of theta oscillationsAssociated with clinical outcomesMismatch negativity deficitsOddball paradigmPsychosis conversionMismatch negativity amplitudeCHR-P samplesEvent-related oscillationsCHR-P individualsPassive auditory oddball paradigmFollow-upSchizophrenia biomarkersStandard tonesSpontaneous head movements during virtual clinical interviews help predict 12-months clinical outcomes in youth at clinical high risk for psychosis
Lozano-Goupil J, Parmacek S, Gold J, Corlett P, Strauss G, Schiffman J, Ellman L, Walker E, Powers A, Woods S, Waltz J, Silverstein S, Mittal V. Spontaneous head movements during virtual clinical interviews help predict 12-months clinical outcomes in youth at clinical high risk for psychosis. Schizophrenia 2025, 11: 137. PMID: 41258211, PMCID: PMC12630965, DOI: 10.1038/s41537-025-00683-1.Peer-Reviewed Original ResearchCitationsAltmetricConceptsClinical high riskClinical InterviewSymptom severityMarker of symptom severityDisorganized symptomsPsychosis vulnerabilitySocial anhedoniaNegative symptomsPositive symptomsBaseline symptomatologyGlobal functioningSpontaneous head movementsMotor behaviorSocial functioningMotor abnormalitiesSocial interactionAvolitionLongitudinal studyPrognostic valuePsychosisEarly interventionHead movementsHigh riskSymptomsSymptom monitoringNeighborhood Characteristics and Social Functioning: Exploring Shared and Distinct Psychosocial Pathways Among Individuals at Clinical High-Risk for Psychosis
Yuan Q, Feurer C, Zhou Q, Carrion R, Addington J, Bearden C, Cadenhead K, Cannon T, Cornblatt B, Keshavan M, Mathalon D, Perkins D, Stone W, Woods S, Walker E, Ku B. Neighborhood Characteristics and Social Functioning: Exploring Shared and Distinct Psychosocial Pathways Among Individuals at Clinical High-Risk for Psychosis. Schizophrenia Bulletin 2025, sbaf192. PMID: 41212179, DOI: 10.1093/schbul/sbaf192.Peer-Reviewed Original ResearchCitationsConceptsNeighborhood socioeconomic deprivationNeighbourhood social fragmentationSocioeconomic deprivationNeighborhood characteristicsAssociated with social functioningContextual risk factorsSocial functioningHigh riskStudy phase 3Impaired social functioningRisk factorsCHR-PSocial fragmentationClinical high riskParticipant's addressGlobal assessmentCHR-P individualsPsychosocial pathwaysGlobal Assessment of FunctioningAssessment of functioningEffective interventionsStructural assessmentStructured Assessment of Violence RiskEnvironmental factorsAssessment of Violence RiskCollecting language, speech acoustics, and facial expression to predict psychosis and other clinical outcomes: strategies from the AMP® SCZ initiative
Bilgrami Z, Castro E, Agurto C, Liebenthal E, Ennis M, Baker J, Scott I, Colton B, Cho K, Li L, Tamayo Z, Henecks M, Rahimi Eichi H, Henry T, Addington J, Alameda L, Arango C, Breitborde N, Broome M, Cadenhead K, Calkins M, Chen E, Choi J, Conus P, Cornblatt B, Ellman L, Fusar-Poli P, Gaspar P, Gerber C, Glenthøj L, Horton L, Hui C, Kambeitz J, Kambeitz-Ilankovic L, Keshavan M, Kim S, Koutsouleris N, Kwon J, Langbein K, Mamah D, Diaz-Caneja C, Mathalon D, Mittal V, Nordentoft M, Pearlson G, Perez J, Perkins D, Powers A, Rogers J, Sabb F, Schiffman J, Shah J, Silverstein S, Smesny S, Stone W, Yassin W, Strauss G, Thompson J, Upthegrove R, Verma S, Wang J, Wolf D, McGorry P, Kahn R, Kane J, Anticevic A, Bearden C, Dwyer D, Billah T, Bouix S, Pasternak O, Shenton M, Woods S, Nelson B, Cecchi G, Corcoran C, Wolff P. Collecting language, speech acoustics, and facial expression to predict psychosis and other clinical outcomes: strategies from the AMP® SCZ initiative. Schizophrenia 2025, 11: 125. PMID: 41093845, PMCID: PMC12528486, DOI: 10.1038/s41537-025-00669-z.Peer-Reviewed Original ResearchCitationsAltmetricConceptsClinical high riskSample taskEarly psychosisClinical high-risk participantsFacial expressionsCommunity controlsSpeech-based detectionDetection of psychosisPsychosis riskReferential languagePsychosisSyntactic embeddingElicitation conditionsNatural language processing parserEveryday speechSpeech acousticsInterviewer trainingMachine-learning classifiersSpeechLanguage modelElevated useComputational linguisticsTaskData integrationLanguage
Clinical Trials
Current Trials
ProNET
IRB ID2000029159RolePrincipal InvestigatorPrimary Completion Date12/31/2024Recruiting ParticipantsSchizophrenia Spectrum Biomarkers Consortium (SSBC)
IRB ID2000029485RoleSub InvestigatorPrimary Completion Date12/31/2030Recruiting ParticipantsStudy of Brain Function Across the Lifespan
IRB ID2000020891RoleSub InvestigatorPrimary Completion Date07/31/2022Recruiting ParticipantsGenderBothAge18 years - 65 yearsSleep Dependent Learning in Schizophrenia and Psychosis Risk Syndrome
IRB ID1201009524RoleSub InvestigatorPrimary Completion Date01/31/2022Recruiting ParticipantsGenderBothAge18 years - 55 years
Academic Achievements & Community Involvement
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News
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News
- April 08, 2026
Yale-NAMI Conference on Neuroscience, Mental Health and Society Scheduled for May 9
- March 23, 2026
Powers Honored with SIRS Research Excellence Award
- February 17, 2026
Yale Psychiatry Ranks Second in Nation in NIH Research Funding
- February 26, 2025
Yale Psychiatry Ranked First in Nation in NIH Research Funding
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Mailing Address
Psychiatry
300 George St
New Haven, CT 06511-
United States
Events
May 20269Saturday
Everyone Vinod H. Srihari, MD - Kristen Brennand, PhD - Scott Woods, MD - Chyrell Bellamy, MSW, PhD - Rev. Robyn Anderson