2008
Mapping DNA Adducts of Mitomycin C and Decarbamoyl Mitomycin C in Cell Lines Using Liquid Chromatography/Electrospray Tandem Mass Spectrometry
Paz MM, Ladwa S, Champeil E, Liu Y, Rockwell S, Boamah EK, Bargonetti J, Callahan J, Roach J, Tomasz M. Mapping DNA Adducts of Mitomycin C and Decarbamoyl Mitomycin C in Cell Lines Using Liquid Chromatography/Electrospray Tandem Mass Spectrometry. Chemical Research In Toxicology 2008, 21: 2370-2378. PMID: 19053323, PMCID: PMC2630229, DOI: 10.1021/tx8002615.Peer-Reviewed Original ResearchConceptsBreast cancer cellsMitomycin CCancer cellsMCF-7 human breast cancer cellsEMT6 cellsEMT6 mouse mammary tumor cellsHuman breast cancer cellsMCF-7 breast cancer cellsMouse mammary tumor cellsMammary tumor cellsMCF-7 cellsHuman fibroblastsMitomycin C treatmentTumor cellsReductive metabolitesDecarbamoyl mitomycin CNormal human fibroblasts
1999
The molecular and cellular basis of radiosensitivity: implications for understanding how normal tissues and tumors respond to therapeutic radiation.
Rosen E, Fan S, Rockwell S, Goldberg I. The molecular and cellular basis of radiosensitivity: implications for understanding how normal tissues and tumors respond to therapeutic radiation. Cancer Investigation 1999, 17: 56-72. PMID: 10999050, DOI: 10.3109/07357909909011718.Peer-Reviewed Original ResearchMeSH KeywordsAcute DiseaseAnimalsApoptosisAtaxia Telangiectasia Mutated ProteinsBRCA1 ProteinCell CycleCell Cycle ProteinsCell Transformation, NeoplasticCellsCHO CellsCricetinaeCytokinesDNADNA DamageDNA RepairDNA-Binding ProteinsGenesGenes, BRCA1Genes, p53Growth SubstancesHumansNeoplasmsNeoplasms, Radiation-InducedOncogene ProteinsOncogenesProtein Serine-Threonine KinasesRadiation ToleranceRadiotherapySignal TransductionTime FactorsTumor Suppressor Protein p53Tumor Suppressor ProteinsConceptsGrowth factor signal transductionDNA damage responseCell cycle progressionCellular functionsDamage responseSignal transductionOverexpress proteinsCandidate genesCycle progressionMolecular mechanismsGenetic instabilityFunction mutationsCell typesCellular radiosensitivityCellular basisCellular mechanismsNormal tissuesGenesMutationsRadiosensitivityRecent studiesSevere normal tissue damageMild effectIndividual tumorsTransduction