Research & Publications
Dr. Rong Fan is Professor of Biomedical Engineering at Yale University. His research interest has been centered on the development and deployment of single-cell omics and high-resolution spatial omics technologies to investigate complex human diseases. He received a B.S. in Applied Chemistry from University of Science and Technology of China, a Ph.D. in Chemistry from the University of California at Berkeley, and then completed his postdoctoral training at California Institute of Technology, prior to joining the faculty of Department of Biomedical Engineering at Yale University in 2010. His latest contribution to science and engineering include the development of single-cell functional omics technologies and microengineered tissue models to interrogate cellular heterogeneity, activation states, and dynamics in cancer and the immune system. He developed a microchip that allows for simultaneous measurement of 42 immune effector proteins in single cells at high throughput, which remains the highest multiplexing to date for a single-cell protein secretion assay. In collaboration with Novartis and Kite Pharma, it was applied to profiling antigen-specific activation states of chimeric antigen receptor (CAR)-engineered T cells, resulting in the discovery of novel single-cell biomarkers including polyfunctional strength index to characterize the quality of CAR-T infusion products and predict the clinical responses and immune-related adverse effects(irAEs) prior to treatment. This microchip, called IsoCode, and the automation system, called IsoLight, have been commercialized by IsoPlexis, a company co-founded by Dr. Fan. Now, this system has been used by >50 major pharmaceutical companies and cancer centers/hospitals around the world for monitoring CAR-T or checkpoint inhibitor immunotherapies. In addition, Dr. Fan is also working to develop high-throughput methods for single-cell epigenomic, transcriptomic, and epi-transcriptomics such as microRNAs. Recently, his laboratory is working on the development of high-spatial-resolution spatial multi-omics atlas sequencing which may find widespread applications in developmental biology, neuroscience, cancer research, immunobiology and clinical pathology. Dr. Fan co-founded IsoPlexis and Singleron Biotechnologies. He is the recipient of numerous awards including the NCI Howard Temin Career Transition Award, the NSF CAREER Award, and the Packard Fellowship for Science and Engineering. He is elected a Fellow of American Institute for Medical and Biological Engineering (AIMBE) and a Senior Member of National Academy of Inventors (NAI).
Education & Training
- PhDUniversity of California, Berkeley (2006)
- MSUniversity of Science and Technology of China (2001)
- BSUniversity of Science and Technology of China (1999)