2025
Genetic deficiency or pharmacological inhibition of cGAS–STING signalling suppresses kidney inflammation and fibrosis
Jiao B, An C, Du H, Tran M, Yang D, Zhao Y, Wang P, Hu Z, Zhou D, Wang Y. Genetic deficiency or pharmacological inhibition of cGAS–STING signalling suppresses kidney inflammation and fibrosis. British Journal Of Pharmacology 2025 PMID: 39833988, DOI: 10.1111/bph.17412.Peer-Reviewed Original ResearchChronic kidney diseaseMacrophage proinflammatory activationDevelopment of renal fibrosisObstructive injuryCGAS-STING signalingProinflammatory activityCGAS-STINGRenal inflammationRenal fibrosisPharmacological inhibitionMyofibroblast formationDamaged tubular epithelial cellsCyclic GMP-AMP synthase (cGAS)-stimulatorBone marrow-derived macrophagesAttenuated kidney fibrosisMarrow-derived macrophagesCGAS-STING signaling pathwayTubular epithelial cellsSignaling in vitroCell-derived DNAPreclinical modelsTubular atrophySTING deficiencyInhibition of cGASKidney inflammation
2021
STAT6 Deficiency Attenuates Myeloid Fibroblast Activation and Macrophage Polarization in Experimental Folic Acid Nephropathy
Jiao B, An C, Du H, Tran M, Wang P, Zhou D, Wang Y. STAT6 Deficiency Attenuates Myeloid Fibroblast Activation and Macrophage Polarization in Experimental Folic Acid Nephropathy. Cells 2021, 10: 3057. PMID: 34831280, PMCID: PMC8623460, DOI: 10.3390/cells10113057.Peer-Reviewed Original ResearchConceptsFolic acid nephropathySTAT6 knockout miceM2 macrophage polarizationRenal fibrosis developmentMacrophage polarizationKidney diseaseFibroblast activationKnockout miceRenal fibrosisFibrosis developmentMyeloid fibroblastsEnd-stage kidney diseaseChronic kidney diseaseSevere interstitial fibrosisFibrotic kidney diseaseWild-type miceNovel therapeutic strategiesExtracellular matrix protein productionMatrix protein productionKidney functionPathologic featuresInterstitial fibrosisFibroblast accumulationNephropathyMouse modelPharmacological Inhibition of STAT6 Ameliorates Myeloid Fibroblast Activation and Alternative Macrophage Polarization in Renal Fibrosis
Jiao B, An C, Tran M, Du H, Wang P, Zhou D, Wang Y. Pharmacological Inhibition of STAT6 Ameliorates Myeloid Fibroblast Activation and Alternative Macrophage Polarization in Renal Fibrosis. Frontiers In Immunology 2021, 12: 735014. PMID: 34512669, PMCID: PMC8426438, DOI: 10.3389/fimmu.2021.735014.Peer-Reviewed Original ResearchConceptsChronic kidney diseaseFolic acid administrationUnilateral ureteral obstructionRenal fibrosisM2 macrophage polarizationMacrophage polarizationUreteral obstructionFibroblast activationAcid administrationKidney functionKidney diseaseKidney fibrosisPreserves kidney functionSTAT6 activationVehicle-treated miceFolic acid nephropathyExperimental murine modelAlternative macrophage polarizationWild-type miceNovel therapeutic approachesExtracellular matrix protein productionSTAT6 inhibitorMatrix protein productionAS1517499Effective therapy