Xuan Yang, PhD
Postdoctoral AssociateDownloadHi-Res Photo
About
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Titles
Postdoctoral Associate
Appointments
Immunobiology
Postdoctoral AssociatePrimary
Other Departments & Organizations
Education & Training
- PhD
- Yale University, Immunology (2025)
- MS
- Emory University, Cancer Biology and Translational Oncology (2019)
- BS
- Emory University, Biology (2018)
- AA
- Emory University, Liberal Arts and Sciences (2016)
Research
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Overview
Medical Research Interests
Drug Development; Drug Discovery; Drug Screening Assays, Antitumor; High-Throughput Screening Assays; Immunotherapy; Therapeutics; Tumor Microenvironment
ORCID
0000-0002-7799-7705
Research at a Glance
Yale Co-Authors
Frequent collaborators of Xuan Yang's published research.
Publications Timeline
A big-picture view of Xuan Yang's research output by year.
Research Interests
Research topics Xuan Yang is interested in exploring.
Lieping Chen, MD, PhD
Dejian Zhao, PhD
Jacky Yeung
Kurt Schalper, MD, PhD
Miguel Sanmamed, MD, PhD
Solomon Langermann
9Publications
224Citations
Immunotherapy
Drug Discovery
Tumor Microenvironment
Publications
2025
Why has immune “checkpoint” therapy failed in most clinical trials?
Yang X, Chen L. Why has immune “checkpoint” therapy failed in most clinical trials? Journal For ImmunoTherapy Of Cancer 2025, 13: e012457. PMID: 40866292, PMCID: PMC12410618, DOI: 10.1136/jitc-2025-012457.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsCitations
2024
Up-regulated PLA2G10 in cancer impairs T cell infiltration to dampen immunity
Zhang T, Yu W, Cheng X, Yeung J, Ahumada V, Norris P, Pearson M, Yang X, van Deursen W, Halcovich C, Nassar A, Vesely M, Zhang Y, Zhang J, Ji L, Flies D, Liu L, Langermann S, LaRochelle W, Humphrey R, Zhao D, Zhang Q, Zhang J, Gu R, Schalper K, Sanmamed M, Chen L. Up-regulated PLA2G10 in cancer impairs T cell infiltration to dampen immunity. Science Immunology 2024, 9: eadh2334. PMID: 38669316, DOI: 10.1126/sciimmunol.adh2334.Peer-Reviewed Original ResearchCitationsAltmetric
2022
Systematic discovery of mutation-directed neo-protein-protein interactions in cancer
Mo X, Niu Q, Ivanov A, Tsang Y, Tang C, Shu C, Li Q, Qian K, Wahafu A, Doyle S, Cicka D, Yang X, Fan D, Reyna M, Cooper L, Moreno C, Zhou W, Owonikoko T, Lonial S, Khuri F, Du Y, Ramalingam S, Mills G, Fu H. Systematic discovery of mutation-directed neo-protein-protein interactions in cancer. Cell 2022, 185: 1974-1985.e12. PMID: 35512704, PMCID: PMC9597701, DOI: 10.1016/j.cell.2022.04.014.Peer-Reviewed Original ResearchCitationsAltmetric
2021
Discovery of the first chemical tools to regulate MKK3-mediated MYC activation in cancer
Yang X, Fan D, Troha A, Ahn H, Qian K, Liang B, Du Y, Fu H, Ivanov A. Discovery of the first chemical tools to regulate MKK3-mediated MYC activation in cancer. Bioorganic & Medicinal Chemistry 2021, 45: 116324. PMID: 34333394, PMCID: PMC8456368, DOI: 10.1016/j.bmc.2021.116324.Peer-Reviewed Original ResearchCitationsAltmetricMeSH KeywordsAntineoplastic AgentsCell SurvivalCells, CulturedDose-Response Relationship, DrugDrug DiscoveryHumansMAP Kinase Kinase 3Molecular Docking SimulationMolecular StructureNeoplasmsProtein BindingProtein Kinase InhibitorsProto-Oncogene Proteins c-mycSmall Molecule LibrariesStructure-Activity Relationship
2020
Hypomorph mutation-directed small-molecule protein-protein interaction inducers to restore mutant SMAD4-suppressed TGF-β signaling
Tang C, Mo X, Niu Q, Wahafu A, Yang X, Qui M, Ivanov A, Du Y, Fu H. Hypomorph mutation-directed small-molecule protein-protein interaction inducers to restore mutant SMAD4-suppressed TGF-β signaling. Cell Chemical Biology 2020, 28: 636-647.e5. PMID: 33326750, PMCID: PMC10053325, DOI: 10.1016/j.chembiol.2020.11.010.Peer-Reviewed Original ResearchCitationsAltmetricHigh expression of MKK3 is associated with worse clinical outcomes in African American breast cancer patients
Yang X, Amgad M, Cooper L, Du Y, Fu H, Ivanov A. High expression of MKK3 is associated with worse clinical outcomes in African American breast cancer patients. Journal Of Translational Medicine 2020, 18: 334. PMID: 32873298, PMCID: PMC7465409, DOI: 10.1186/s12967-020-02502-w.Peer-Reviewed Original ResearchCitationsAltmetricOnline informatics resources to facilitate cancer target and chemical probe discovery
Yang X, Fu H, Ivanov A. Online informatics resources to facilitate cancer target and chemical probe discovery. RSC Medicinal Chemistry 2020, 11: 611-624. PMID: 33479663, PMCID: PMC7429978, DOI: 10.1039/d0md00012d.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsCitationsComputational structural modeling to discover PPI modulators
Yang X, Ivanov AA. Computational structural modeling to discover PPI modulators. Protein-protein interaction regulators, 87-108, Roy, S. & Fu, H. (Eds.) Royal Society of Chemistry.ChaptersCHAPTER 4 Computational Structural Modeling to Discover PPI Modulators
Yang X, Ivanov A. CHAPTER 4 Computational Structural Modeling to Discover PPI Modulators. 2020, 87-108. DOI: 10.1039/9781788016544-00087.ChaptersCitations
Academic Achievements & Community Involvement
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Honors
honor NIH/NCI F99/K00 Award
08/21/2024National AwardNational Cancer InstituteDetailsUnited Stateshonor Prize Teaching Award
04/19/2024Yale University AwardYale UniversityDetailsUnited Stateshonor Gruber Science Fellowship
08/30/2021Yale University AwardYale UniversityDetailsUnited Stateshonor SLAS Tony B. Academic Travel Award
01/25/2020National AwardSociety for Laboratory Automation and ScreeningDetailsUnited Stateshonor ASPET Travel Award
04/06/2019National AwardAmerican Society for Pharmacology and Experimental TherapeuticsDetailsUnited States