2023
Dynamic cerebral autoregulation in postpartum individuals with and without preeclampsia
Miller E, Katsidoniotaki M, Haghighi N, Dos Santos K, Booker W, Petersen N, Wapner R, Bello N, Kougioumtzoglou I, Marshall R. Dynamic cerebral autoregulation in postpartum individuals with and without preeclampsia. Pregnancy Hypertension 2023, 33: 39-45. PMID: 37524001, PMCID: PMC10528950, DOI: 10.1016/j.preghy.2023.07.176.Peer-Reviewed Original ResearchConceptsDynamic cerebral autoregulationFirst week postpartumPostpartum individualsSevere featuresCerebral autoregulationPostpartum groupPreeclampsia diagnosisWeeks postpartumHistorical controlsFemale volunteersNon-pregnant female volunteersContinuous arterial blood pressureArterial blood pressureNon-pregnant volunteersDiagnosis of preeclampsiaHealthy non-pregnant female volunteersCerebrovascular complicationsBlood pressureTranscranial DopplerPostpartum participantsAutoregulatory responseFinger plethysmographyKruskal-Wallis testPreeclampsiaAutoregulation parametersReduced-order modeling and analysis of dynamic cerebral autoregulation via diffusion maps
dos Santos K, Katsidoniotaki M, Miller E, Petersen N, Marshall R, Kougioumtzoglou I. Reduced-order modeling and analysis of dynamic cerebral autoregulation via diffusion maps. Physiological Measurement 2023, 44: 044001. PMID: 36963111, PMCID: PMC11271258, DOI: 10.1088/1361-6579/acc780.Peer-Reviewed Original ResearchMeSH KeywordsArterial PressureCarotid StenosisConstriction, PathologicHomeostasisHumansReproducibility of ResultsConceptsDiffusion mapsState-space descriptionReduced-order modelingIntrinsic dynamicsTime derivativeLow-dimensional representationRandom walkMarkov matrixParsimonious modelingSignificant eigenvaluesEigenvalue ratioFurther dimension reductionEigenvalue analysisTransfer function analysisDimension reductionData-driven techniquesMain resultsDynamicsEigenvaluesFlow velocityModelingSuperior performanceMap techniqueGraphWalk
2021
Review of studies on dynamic cerebral autoregulation in the acute phase of stroke and the relationship with clinical outcome
Nogueira R, Aries M, Minhas J, Petersen N, Xiong L, Kainerstorfer J, Castro P. Review of studies on dynamic cerebral autoregulation in the acute phase of stroke and the relationship with clinical outcome. Cerebrovascular And Brain Metabolism Reviews 2021, 42: 430-453. PMID: 34515547, PMCID: PMC8985432, DOI: 10.1177/0271678x211045222.Peer-Reviewed Original ResearchConceptsDynamic cerebral autoregulationAcute phaseClinical outcomesCerebral autoregulationAcute ischemic strokeCerebral hemodynamic parametersPotential therapeutic targetCerebrovascular disease statesAcute strokeIschemic strokeStroke onsetCerebral perfusionCerebral circulationIntracerebral hemorrhageHigh morbidityHemodynamic parametersIndividual patientsPerfusion interventionsNew therapiesTherapeutic targetHemodynamic aspectsPatientsAdditional treatmentDisease statesRelevant studies
2020
Fixed Compared With Autoregulation-Oriented Blood Pressure Thresholds After Mechanical Thrombectomy for Ischemic Stroke
Petersen NH, Silverman A, Strander SM, Kodali S, Wang A, Sansing LH, Schindler JL, Falcone GJ, Gilmore EJ, Jasne AS, Cord B, Hebert RM, Johnson M, Matouk CC, Sheth KN. Fixed Compared With Autoregulation-Oriented Blood Pressure Thresholds After Mechanical Thrombectomy for Ischemic Stroke. Stroke 2020, 51: 914-921. PMID: 32078493, PMCID: PMC7050651, DOI: 10.1161/strokeaha.119.026596.Peer-Reviewed Original ResearchConceptsSystolic BP thresholdMean arterial pressureArterial pressureEndovascular thrombectomyIschemic strokeSystolic BPFunctional outcomePercent timeFurther brain injuryModified Rankin ScaleBlood pressure changesPoor functional outcomeBP thresholdAutoregulatory indexHemorrhagic transformationMechanical thrombectomyRankin ScaleBlood pressureBP targetsHemodynamic managementAcute phaseBP managementStroke patientsCerebral autoregulationWorse outcomes
2019
Deviation From Personalized Blood Pressure Targets Is Associated With Worse Outcome After Subarachnoid Hemorrhage
Silverman A, Kodali S, Strander S, Gilmore EJ, Kimmel A, Wang A, Cord B, Falcone G, Hebert R, Matouk C, Sheth KN, Petersen NH. Deviation From Personalized Blood Pressure Targets Is Associated With Worse Outcome After Subarachnoid Hemorrhage. Stroke 2019, 50: 2729-2737. PMID: 31495332, PMCID: PMC6756936, DOI: 10.1161/strokeaha.119.026282.Peer-Reviewed Original ResearchConceptsLimits of autoregulationAneurysmal subarachnoid hemorrhageSubarachnoid hemorrhageFunctional outcomeArterial pressureIntracranial pressureBP targetsWorse outcomesPercent timeBlood pressure targetsBlood pressure managementMean arterial pressureModified Rankin ScalePotential neuroprotective strategiesWorse functional outcomePoor functional outcomeCerebral blood flowMultivariate logistic regressionTotal monitoring periodAutoregulatory indexPressure targetsCerebral ischemiaNeuroprotective strategiesRankin ScaleCerebral autoregulationChanges on Dynamic Cerebral Autoregulation Are Associated with Delayed Cerebral Ischemia in Patients with Aneurysmal Subarachnoid Hemorrhage
Ortega-Gutierrez S, Samaniego E, Reccius A, Huang A, Zheng-Lin B, Masukar A, Marshall R, Petersen N. Changes on Dynamic Cerebral Autoregulation Are Associated with Delayed Cerebral Ischemia in Patients with Aneurysmal Subarachnoid Hemorrhage. Acta Neurochirurgica Supplement 2019, 127: 149-153. PMID: 31407076, DOI: 10.1007/978-3-030-04615-6_22.Peer-Reviewed Original ResearchMeSH KeywordsBrain IschemiaCohort StudiesHomeostasisHumansSubarachnoid HemorrhageVasospasm, IntracranialConceptsDynamic cerebral autoregulationAneurysmal subarachnoid hemorrhageCerebral blood flow velocityBlood pressureSymptomatic vasospasmCerebral ischemiaSAH patientsCerebral autoregulationSubarachnoid hemorrhageCerebral blood flow regulationGlasgow Coma ScoreSystemic blood pressureDelayed Cerebral IschemiaLarge cohort studyBlood flow regulationBlood flow velocityRecording periodDCA assessmentCohort studyComa ScoreEntire recording periodSymptom onsetMedian timeDay 3Early identification
2015
Dynamic Cerebral Autoregulation Is Transiently Impaired for One Week after Large-Vessel Acute Ischemic Stroke
Petersen NH, Ortega-Gutierrez S, Reccius A, Masurkar A, Huang A, Marshall RS. Dynamic Cerebral Autoregulation Is Transiently Impaired for One Week after Large-Vessel Acute Ischemic Stroke. Cerebrovascular Diseases 2015, 39: 144-150. PMID: 25661277, PMCID: PMC4754197, DOI: 10.1159/000368595.Peer-Reviewed Original ResearchConceptsDynamic cerebral autoregulationLarge-vessel ischemic strokeUnaffected hemisphereAffected hemisphereIschemic strokeCerebral autoregulationBlood pressureAcute large-vessel ischemic strokeLarge vessel acute ischemic strokeAcute blood pressure managementMiddle cerebral artery territoryAcute ischemic strokeBlood pressure managementCerebral blood flowBlood flow velocityDay strokePoor autoregulationAcute strokeArtery territoryArterial catheterTranscranial DopplerAffected sideUnaffected sideControl subjectsHealthy controls
2014
Comparison of non-invasive and invasive arterial blood pressure measurement for assessment of dynamic cerebral autoregulation.
Petersen NH, Ortega-Gutierrez S, Reccius A, Masurkar A, Huang A, Marshall RS. Comparison of non-invasive and invasive arterial blood pressure measurement for assessment of dynamic cerebral autoregulation. Neurocritical Care 2014, 20: 60-8. PMID: 24452959, DOI: 10.1007/s12028-013-9949-4.Peer-Reviewed Original ResearchConceptsDynamic cerebral autoregulationAssessment of DCAAcute brain injuryBlood pressure monitoringBlood pressure measurementsCerebral autoregulationBrain injuryPressure monitoringInvasive arterial blood pressure measurementsInvasive arterial blood pressure monitoringGood inter-method agreementArterial blood pressure monitoringCerebral blood flow velocityArterial blood pressure measurementsDirect intravascular measurementMean velocity indexMean patient ageArterial blood pressureRadial artery catheterCerebral blood flowMonitoring of patientsBlood flow velocityBlood pressure methodDCA assessmentArtery catheter