2025
Imaging Demyelinated Axons After Spinal Cord Injuries with PET Tracer [18F]3F4AP
Ramos-Torres K, Conti S, Zhou Y, Tiss A, Caravagna C, Takahashi K, He M, Wilks M, Eckl S, Sun Y, Biundo J, Gong K, He Z, Linnman C, Brugarolas P. Imaging Demyelinated Axons After Spinal Cord Injuries with PET Tracer [18F]3F4AP. Journal Of Nuclear Medicine 2025, jnumed.124.268242. PMID: 39819685, DOI: 10.2967/jnumed.124.268242.Peer-Reviewed Original ResearchSpinal cord injuryDemyelinated axonsIncomplete injuryPostmortem spinal cord tissueSpinal cord blood flowSpinal cord injury ratsResponse to therapyCord injuryCord blood flowManagement of spinal cord injurySpinal cord tissuePET imaging resultsSensitive to injuryInjured segmentContusion injuryAxonal lossCord tissueDemyelinating changesAnimal modelsDemyelinationPET imagingBlood flowPET tracersWorsening disabilityTracer binding
2020
Evaluation of the potassium channel tracer [18F]3F4AP in rhesus macaques
Guehl N, Ramos-Torres K, Linnman C, Moon S, Dhaynaut M, Wilks M, Han P, Ma C, Neelamegam R, Zhou Y, Popko B, Correia J, Reich D, Fakhri G, Herscovitch P, Normandin M, Brugarolas P. Evaluation of the potassium channel tracer [18F]3F4AP in rhesus macaques. Cerebrovascular And Brain Metabolism Reviews 2020, 41: 1721-1733. PMID: 33090071, PMCID: PMC8221756, DOI: 10.1177/0271678x20963404.Peer-Reviewed Original ResearchConceptsFocal brain injuryMyelin repair therapyContributions of demyelinationDrivers of disabilityImaging demyelinationBrain injuryMeasurements of molecular changesTool's sensitivity to changesLower myelin contentDemyelinating lesionsNeuronal conductionImpaired conductionDemyelinationBrain penetrationGold standardRhesus macaquesInjured areaMultiple sclerosisMolecular changesMyelin sheathNeurological diseasesHigh metabolic stabilityMRI methodsMRIInjury