Katherine Leiby, PhD
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Biography
Katherine is an MD/PhD candidate at the Yale School of Medicine. She received her PhD in Biomedical Engineering in 2022, working in the lab of Laura Niklason. Her research focuses on lung alveolar tissue engineering, with a particular interest in applying physiological principles and insights from stem cell biology to achieve tissue regeneration or repair. Prior to starting medical school, she received her BS in Biomedical Engineering from Yale. She plans to pursue a career as an academic surgeon-scientist.
Last Updated on November 28, 2022.
Education & Training
- PhD
- Yale University, Biomedical Engineering (2022)
- BS
- Yale University, Biomedical Engineering (2014)
Research
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Overview
My research focuses on applying physiological principles, insights from stem cell biology, and single-cell RNA sequencing to engineer tissue regeneration or repair within a deliberate and rationally-designed framework.
Medical Research Interests
Regenerative Medicine; Stem Cells; Tissue Engineering
ORCID
0000-0003-3409-9371
Research at a Glance
Yale Co-Authors
Frequent collaborators of Katherine Leiby's published research.
Publications Timeline
A big-picture view of Katherine Leiby's research output by year.
Research Interests
Research topics Katherine Leiby is interested in exploring.
Micha Sam Brickman Raredon, MD, PhD
Allison M. Greaney, PhD
Naftali Kaminski, MD
Jonas Christian Schupp, MD
Laura Niklason, PhD, MD
Pavlina Baevova
17Publications
860Citations
Tissue Engineering
Publications
2023
Rational engineering of lung alveolar epithelium
Leiby K, Yuan Y, Ng R, Raredon M, Adams T, Baevova P, Greaney A, Hirschi K, Campbell S, Kaminski N, Herzog E, Niklason L. Rational engineering of lung alveolar epithelium. Npj Regenerative Medicine 2023, 8: 22. PMID: 37117221, PMCID: PMC10147714, DOI: 10.1038/s41536-023-00295-2.Peer-Reviewed Original ResearchCitationsAltmetricConcepts
2022
Computation and visualization of cell–cell signaling topologies in single-cell systems data using Connectome
Raredon MSB, Yang J, Garritano J, Wang M, Kushnir D, Schupp JC, Adams TS, Greaney AM, Leiby KL, Kaminski N, Kluger Y, Levchenko A, Niklason LE. Computation and visualization of cell–cell signaling topologies in single-cell systems data using Connectome. Scientific Reports 2022, 12: 4187. PMID: 35264704, PMCID: PMC8906120, DOI: 10.1038/s41598-022-07959-x.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and Concepts
2021
A Pulmonary Vascular Model From Endothelialized Whole Organ Scaffolds
Yuan Y, Leiby KL, Greaney AM, Raredon MSB, Qian H, Schupp JC, Engler AJ, Baevova P, Adams TS, Kural MH, Wang J, Obata T, Yoder MC, Kaminski N, Niklason LE. A Pulmonary Vascular Model From Endothelialized Whole Organ Scaffolds. Frontiers In Bioengineering And Biotechnology 2021, 9: 760309. PMID: 34869270, PMCID: PMC8640093, DOI: 10.3389/fbioe.2021.760309.Peer-Reviewed Original ResearchCitationsAltmetricConceptsVascular diseaseEndothelial phenotypeLung vascular diseaseAcute lung injuryPulmonary microvascular functionWhole lung scaffoldsVascular barrier functionLung injuryMicrovascular functionEndothelial cell coverageSingle-cell RNA-sequencing analysisLPS treatmentProinflammatory signalsWhole lungLung endotheliumLung systemVascular barrierOrgan engineering approachesBarrier functionLungWhole-organ scaffoldsVascular structuresDrug mechanismsEndotheliumDiseaseAn ex vivo physiologic and hyperplastic vessel culture model to study intra-arterial stent therapies
Wang J, Kural MH, Wu J, Leiby KL, Mishra V, Lysyy T, Li G, Luo J, Greaney A, Tellides G, Qyang Y, Huang N, Niklason LE. An ex vivo physiologic and hyperplastic vessel culture model to study intra-arterial stent therapies. Biomaterials 2021, 275: 120911. PMID: 34087584, PMCID: PMC9195126, DOI: 10.1016/j.biomaterials.2021.120911.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsDevelopment of a Bioartificial Vascular Pancreas
Han EX, Wang J, Kural M, Jiang B, Leiby KL, Chowdhury N, Tellides G, Kibbey RG, Lawson JH, Niklason LE. Development of a Bioartificial Vascular Pancreas. Journal Of Tissue Engineering 2021, 12: 20417314211027714. PMID: 34262686, PMCID: PMC8243137, DOI: 10.1177/20417314211027714.Peer-Reviewed Original ResearchCitationsAltmetricConcepts
2020
Bioengineering the Blood‐gas Barrier
Leiby K, Raredon M, Niklason L. Bioengineering the Blood‐gas Barrier. Comprehensive Physiology 2020, 10: 415-452. DOI: 10.1002/j.2040-4603.2020.tb00124.x.Peer-Reviewed Original ResearchCitationsBioengineering the Blood‐gas Barrier
Leiby KL, Raredon MSB, Niklason LE. Bioengineering the Blood‐gas Barrier. 2020, 10: 415-452. PMID: 32163210, PMCID: PMC7366783, DOI: 10.1002/cphy.c190026.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and Concepts
2019
Single-cell connectomic analysis of adult mammalian lungs
Raredon MSB, Adams TS, Suhail Y, Schupp JC, Poli S, Neumark N, Leiby KL, Greaney AM, Yuan Y, Horien C, Linderman G, Engler AJ, Boffa DJ, Kluger Y, Rosas IO, Levchenko A, Kaminski N, Niklason LE. Single-cell connectomic analysis of adult mammalian lungs. Science Advances 2019, 5: eaaw3851. PMID: 31840053, PMCID: PMC6892628, DOI: 10.1126/sciadv.aaw3851.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsTissue homeostasisMammalian lungSingle-cell RNA sequencing techniquesAdult mammalian lungRNA sequencing techniquesCell-cell interactionsSequencing techniquesKey pathwaysAlveolar type IFunctional roleCell typesCell populationsRegenerative medicineHomeostatic mechanismsHomeostasisFine architectureFunctional lung tissueIncomplete understandingMajor roleType ITissueRegulationPathwayAlveolar cell populationsDistal lung
2017
Bioengineered lungs generated from human iPSCs‐derived epithelial cells on native extracellular matrix
Ghaedi M, Le AV, Hatachi G, Beloiartsev A, Rocco K, Sivarapatna A, Mendez JJ, Baevova P, Dyal RN, Leiby KL, White ES, Niklason LE. Bioengineered lungs generated from human iPSCs‐derived epithelial cells on native extracellular matrix. Journal Of Tissue Engineering And Regenerative Medicine 2017, 12: e1623-e1635. PMID: 29024475, PMCID: PMC5991621, DOI: 10.1002/term.2589.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsEpithelial progenitor cellsProgenitor cellsStem cellsEpithelial cellsLung progenitor cellsLung epithelial cellsHuman lungHuman-derived cellsReliable cell sourceNative extracellular matrixEarly stepsExtracellular matrixRat lungImportant early stepHuman iPSCLung regenerationLung tissue regenerationHuman lung tissueIPSCsLung scaffoldsCell sourceCellsEpithelial markersLung transplantationTissue regenerationLung regeneration
Calle EA, Leiby KL, Raredon MB, Niklason LE. Lung regeneration. Current Opinion In Anaesthesiology 2017, 30: 23-29. PMID: 27922848, PMCID: PMC5283945, DOI: 10.1097/aco.0000000000000425.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and Concepts
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