2020
Practice patterns and recommendations for pediatric image‐guided radiotherapy: A Children's Oncology Group report
Hua C, Vern‐Gross T, Hess CB, Olch AJ, Alaei P, Sathiaseelan V, Deng J, Ulin K, Laurie F, Gopalakrishnan M, Esiashvili N, Wolden SL, Krasin MJ, Merchant TE, Donaldson SS, FitzGerald TJ, Constine LS, Hodgson DC, Haas‐Kogan D, Mahajan A, Laack NN, Marcus KJ, Taylor PA, Ahern VA, Followill DS, Buchsbaum JC, Breneman JC, Kalapurakal JA. Practice patterns and recommendations for pediatric image‐guided radiotherapy: A Children's Oncology Group report. Pediatric Blood & Cancer 2020, 67: e28629. PMID: 32776500, PMCID: PMC7774502, DOI: 10.1002/pbc.28629.Peer-Reviewed Original ResearchMeSH KeywordsChildHumansNeoplasmsPractice Guidelines as TopicPractice Patterns, Physicians'Radiation OncologyRadiotherapy DosageRadiotherapy Planning, Computer-AssistedRadiotherapy, Image-GuidedConceptsChildren's Oncology GroupImage-guided radiotherapyOncology GroupPractice patternsOncology disciplinesChildren's Oncology Group reportPaediatric radiotherapy patientsTreatment modalitiesExpert guidelinesDose reductionRadiotherapy patientsPractice recommendationsSetup correctionAdaptive therapyRadiotherapyImage guidanceReportMember surveyGroup ReportPatientsTherapyCliniciansA general-purpose Monte Carlo particle transport code based on inverse transform sampling for radiotherapy dose calculation
Liang Y, Muhammad W, Hart GR, Nartowt BJ, Chen ZJ, Yu JB, Roberts KB, Duncan JS, Deng J. A general-purpose Monte Carlo particle transport code based on inverse transform sampling for radiotherapy dose calculation. Scientific Reports 2020, 10: 9808. PMID: 32555530, PMCID: PMC7300009, DOI: 10.1038/s41598-020-66844-7.Peer-Reviewed Original ResearchMeSH KeywordsCobalt RadioisotopesFeasibility StudiesMonte Carlo MethodParticle AcceleratorsPhantoms, ImagingRadiation DosageRadiotherapy DosageRadiotherapy Planning, Computer-AssistedWaterConceptsPhoton transportBoundary crossing algorithmMonte Carlo particle transport codeMonte Carlo methodTransport simulationsAcceptance-rejection samplingRadiotherapy dose calculationsPhoto-electric effectParticle transport codeEGSnrc simulationsCarlo methodBremsstrahlung eventsInelastic scatteringPair productionRayleigh scatteringThread divergenceMC simulationsTransport codeMC codeHistory schemeParticle transportCrossing algorithmInverseElectron transportSimulation accuracy
2019
Beam modeling and beam model commissioning for Monte Carlo dose calculation‐based radiation therapy treatment planning: Report of AAPM Task Group 157
Charlie C, Chetty IJ, Deng J, Faddegon B, Jiang SB, Li J, Seuntjens J, Siebers JV, Traneus E. Beam modeling and beam model commissioning for Monte Carlo dose calculation‐based radiation therapy treatment planning: Report of AAPM Task Group 157. Medical Physics 2019, 47: e1-e18. PMID: 31679157, DOI: 10.1002/mp.13898.Peer-Reviewed Original ResearchMeSH KeywordsModels, TheoreticalMonte Carlo MethodRadiation DosageRadiotherapy DosageRadiotherapy Planning, Computer-AssistedResearch ReportConceptsBeam modelElectron beam dose calculationsMonte Carlo methodRadiotherapy dose calculationsTreatment planning systemDose calculationsClinical beam modelCarlo methodBeam modelingRadiation therapy treatment planningMC simulationsTherapy treatment planningElectron beamTreatment headClinical photonRadiotherapy treatment planningGeneral approachCalculationsHigh accuracyPractical procedureAccuracyModelClinical physicistsAnalytical methodBeam delivery
2016
Energy Modulated Photon Radiotherapy: A Monte Carlo Feasibility Study
Zhang Y, Feng Y, Ming X, Deng J. Energy Modulated Photon Radiotherapy: A Monte Carlo Feasibility Study. BioMed Research International 2016, 2016: 7319843. PMID: 26977413, PMCID: PMC4763028, DOI: 10.1155/2016/7319843.Peer-Reviewed Original ResearchMeSH KeywordsChildFemaleHumansMaleMonte Carlo MethodNeoplasmsPhotonsRadiometryRadiotherapy DosageRadiotherapy Planning, Computer-AssistedRadiotherapy, Intensity-ModulatedConceptsIMRT plansPediatric brain tumorsNovel treatment modalitiesNormal tissue sparingDifferent tumor sitesDosimetric gainLung cancerTreatment modalitiesIndividual patientsBrain tumorsTissue sparingIMRT techniqueTumor sitePersonalized carePhoton radiotherapyThyroid lesionsDose distributionIntegral doseRadiotherapy treatmentInverse planning systemPatientsRadiotherapyFeasibility studyModern radiotherapy treatmentsClinical IMRT plans
2015
Intermediate Megavoltage Photon Beams for Improved Lung Cancer Treatments
Zhang Y, Feng Y, Ahmad M, Ming X, Zhou L, Deng J. Intermediate Megavoltage Photon Beams for Improved Lung Cancer Treatments. PLOS ONE 2015, 10: e0145117. PMID: 26672752, PMCID: PMC4682946, DOI: 10.1371/journal.pone.0145117.Peer-Reviewed Original ResearchMeSH KeywordsAlgorithmsDose Fractionation, RadiationEsophagusHeartHumansLung NeoplasmsProton TherapyRadiotherapy Planning, Computer-AssistedSpinal CordTracheaConceptsDosimetric benefitsPotential dosimetric benefitsTarget coverageComparable target coverageLung cancer patientsLung cancer treatmentBetter target coverageCurrent treatment approachesImproved tumor coverageNormal tissue dosesTumor dose coverageLung cancer radiotherapyAdjacent critical structuresCritical structuresLung doseCancer patientsLung cancerThin patientsLung volumeLung tumorsDose coverageTreatment approachesPatientsReduced dosesTumor coverageCardiac Exposure in the Dynamic Conformal Arc Therapy, Intensity-Modulated Radiotherapy and Volumetric Modulated Arc Therapy of Lung Cancer
Ming X, Feng Y, Liu H, Zhang Y, Zhou L, Deng J. Cardiac Exposure in the Dynamic Conformal Arc Therapy, Intensity-Modulated Radiotherapy and Volumetric Modulated Arc Therapy of Lung Cancer. PLOS ONE 2015, 10: e0144211. PMID: 26630566, PMCID: PMC4667972, DOI: 10.1371/journal.pone.0144211.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overCardiotoxicityFemaleHeartHumansLungLung NeoplasmsMaleMiddle AgedOrgans at RiskRadiotherapy DosageRadiotherapy Planning, Computer-AssistedRadiotherapy, ConformalRadiotherapy, Intensity-ModulatedRetrospective StudiesConceptsDynamic conformal arc therapyLung cancer patientsIntensity-modulated radiotherapyIrradiated heart volumeCardiac exposureHeart distanceConformal arc therapyCancer patientsHeart volumeArc therapyHeart doseCardiac diseaseLong-term cardiac toxicityMean heart doseMean heart dosesRight lung tumorLung cancer treatmentVolumetric Modulated Arc TherapyRadiotherapy treatment modalitiesInstitutional review boardLung cancer radiotherapyHeart dosesHeart sparingCardiac complicationsHodgkin's disease
2012
Personalized Assessment of kV Cone Beam Computed Tomography Doses in Image-guided Radiotherapy of Pediatric Cancer Patients
Zhang Y, Yan Y, Nath R, Bao S, Deng J. Personalized Assessment of kV Cone Beam Computed Tomography Doses in Image-guided Radiotherapy of Pediatric Cancer Patients. International Journal Of Radiation Oncology • Biology • Physics 2012, 83: 1649-1654. PMID: 22285667, DOI: 10.1016/j.ijrobp.2011.10.072.Peer-Reviewed Original ResearchAdolescentAge FactorsBody SizeBody WeightChildChild, PreschoolCone-Beam Computed TomographyFemaleHeadHumansMaleMonte Carlo MethodNeoplasmsOrgans at RiskPelvisPhantoms, ImagingRadiation DosageRadiation InjuriesRadiotherapy Planning, Computer-AssistedRadiotherapy, Image-GuidedRetrospective StudiesYoung Adult
2011
Testicular Doses in Image-Guided Radiotherapy of Prostate Cancer
Deng J, Chen Z, Yu JB, Roberts KB, Peschel RE, Nath R. Testicular Doses in Image-Guided Radiotherapy of Prostate Cancer. International Journal Of Radiation Oncology • Biology • Physics 2011, 82: e39-e47. PMID: 21489702, DOI: 10.1016/j.ijrobp.2011.01.071.Peer-Reviewed Original ResearchConceptsImage-guided radiotherapyTesticular dosesFull-fan modeProstate cancerFemoral headLess doseCBCT scansHalf-fan modeProstate cancer patientsKilovoltage cone-beamCancer patientsIntensity-modulated radiotherapy (IMRT) treatmentKilovoltage CBCTSuperior-inferior directionCone beamDosesCBCT fieldProstate patientsRectumDoseProstateMore doseRadiotherapy treatmentPatientsRadiotherapy
2008
Clinical implementation of enhanced dynamic wedges into the Pinnacle treatment planning system: Monte Carlo validation and patient-specific QA
Ahmad M, Deng J, Lund MW, Chen Z, Kimmett J, Moran MS, Nath R. Clinical implementation of enhanced dynamic wedges into the Pinnacle treatment planning system: Monte Carlo validation and patient-specific QA. Physics In Medicine And Biology 2008, 54: 447-465. PMID: 19098353, DOI: 10.1088/0031-9155/54/2/018.Peer-Reviewed Original ResearchMeSH KeywordsBiophysical PhenomenaHumansModels, TheoreticalMonte Carlo MethodParticle AcceleratorsPhantoms, ImagingQuality Assurance, Health CareRadiotherapy Planning, Computer-AssistedRadiotherapy, ConformalRadiotherapy, High-EnergyScattering, Radiation
2006
Evaluation of the EDR-2 film for relative dosimetry of high-energy photon and electron beams
Ahmad M, Chen Z, Song H, Deng J, Nath R. Evaluation of the EDR-2 film for relative dosimetry of high-energy photon and electron beams. Radiation Protection Dosimetry 2006, 120: 159-162. PMID: 16644932, DOI: 10.1093/rpd/ncj006.Peer-Reviewed Original ResearchMeSH KeywordsDose-Response Relationship, RadiationElectronsEquipment DesignEquipment Failure AnalysisFilm DosimetryPhotonsRadiation DosageRadiotherapy Planning, Computer-AssistedRadiotherapy, High-EnergyReproducibility of ResultsSensitivity and SpecificityConceptsEDR-2 filmsElectron beamRelative dosimetryHigh-energy photonsClinical radiation dosimetryDose profilesPhotonsRadiation dosimetryBeamDose distributionRadiographic filmsSensitometric studyFilmsDosimetryTreatment planning techniquesElectronsDiodesSymmetryKVFlatnessPlanning techniquesDistributionPotential impact of prostate edema on the dosimetry of permanent seed implants using the new (model CS‐1) seeds
Chen Z, Deng J, Roberts K, Nath R. Potential impact of prostate edema on the dosimetry of permanent seed implants using the new (model CS‐1) seeds. Medical Physics 2006, 33: 968-975. PMID: 16696473, DOI: 10.1118/1.2179170.Peer-Reviewed Original ResearchMeSH KeywordsBrachytherapyCesium RadioisotopesEdemaHumansMaleProstatic NeoplasmsProsthesis ImplantationRadiometryRadiotherapy DosageRadiotherapy Planning, Computer-AssistedReproducibility of ResultsSensitivity and Specificity
2003
Commissioning 6 MV photon beams of a stereotactic radiosurgery system for Monte Carlo treatment planning
Deng J, Ma C, Hai J, Nath R. Commissioning 6 MV photon beams of a stereotactic radiosurgery system for Monte Carlo treatment planning. Medical Physics 2003, 30: 3124-3134. PMID: 14713079, DOI: 10.1118/1.1624753.Peer-Reviewed Original ResearchMeSH KeywordsMonte Carlo MethodPhotonsRadiometryRadiosurgeryRadiotherapy DosageRadiotherapy Planning, Computer-AssistedRadiotherapy, High-EnergyReproducibility of ResultsSensitivity and SpecificityUnited StatesConceptsMonte Carlo dose calculationsMonte Carlo treatment planningBeam phase spaceOutput factorsCentral axis depth dose curvesDose profilesMonte Carlo treatmentMeasurement dataMultiple source modelCyberknife stereotactic radiosurgery systemPhase spaceMV photon beamDepth dose curvesDose calculationsSource modelStereotactic radiosurgery systemFluence distributionStandard measurement dataSource distributionPhoton beamsAxis distanceEnergy spectrumCollimator sizeDose curvesAveraging effectDose correlation for thoracic motion in radiation therapy of breast cancer
Ding M, Li J, Deng J, Fourkal E, Ma C. Dose correlation for thoracic motion in radiation therapy of breast cancer. Medical Physics 2003, 30: 2520-2529. PMID: 14528974, DOI: 10.1118/1.1603744.Peer-Reviewed Original ResearchMeSH KeywordsArtifactsBreast NeoplasmsHumansMammographyMotionMovementOnline SystemsPhantoms, ImagingRadiographic Image Interpretation, Computer-AssistedRadiography, ThoracicRadiometryRadiotherapy DosageRadiotherapy Planning, Computer-AssistedRadiotherapy, Computer-AssistedReproducibility of ResultsRespirationSensitivity and SpecificityStatistics as TopicThoraxTomography, X-Ray ComputedConceptsBreathing patternDose correlationBreast cancerChest wall motionChest wall movementPatient's breathing patternDose dataRadiation therapyThoracic motionRadiotherapy treatmentTreatment planningExpiration phaseDifferent breathing phasesFinal dose distributionCancerBreathing phasesPatient anatomyWall motionTreatmentDose distributionCT dataBreathing levelTherapyDosePatient geometryA comparative dosimetric study on tangential photon beams, intensity-modulated radiation therapy (IMRT) and modulated electron radiotherapy (MERT) for breast cancer treatment
Ma C, Ding M, Li JS, Lee MC, Pawlicki T, Deng J. A comparative dosimetric study on tangential photon beams, intensity-modulated radiation therapy (IMRT) and modulated electron radiotherapy (MERT) for breast cancer treatment. Physics In Medicine And Biology 2003, 48: 909-924. PMID: 12701895, DOI: 10.1088/0031-9155/48/7/308.Peer-Reviewed Original ResearchMeSH KeywordsBreast NeoplasmsComputer SimulationPhotonsRadiometryRadiotherapy DosageRadiotherapy Planning, Computer-AssistedRadiotherapy, ConformalRadiotherapy, High-EnergyConceptsIntensity-modulated radiation therapyTangential photon beamsContralateral breastBreast cancerRadiation therapyTreatment planMaximum doseBreast cancer treatmentTreatment optimizationComparative dosimetric studyBreast treatment plansPhoton treatment plansPhoton beamsElectron radiotherapySuperficial targetsMultiple beam anglesLungMedium dosesDose conformityTangential beamsNormal tissuesCancer treatmentMERT plansIMRT plansMV photon beamA quality assurance phantom for IMRT dose verification
Ma C, Jiang SB, Pawlicki T, Chen Y, Li JS, Deng J, Boyer AL. A quality assurance phantom for IMRT dose verification. Physics In Medicine And Biology 2003, 48: 561-572. PMID: 12696795, DOI: 10.1088/0031-9155/48/5/301.Peer-Reviewed Original Research
2002
A Monte Carlo investigation of fluence profiles collimated by an electron specific MLC during beam delivery for modulated electron radiation therapy
Deng J, Lee MC, Ma C. A Monte Carlo investigation of fluence profiles collimated by an electron specific MLC during beam delivery for modulated electron radiation therapy. Medical Physics 2002, 29: 2472-2483. PMID: 12462711, DOI: 10.1118/1.1513160.Peer-Reviewed Original ResearchMeSH KeywordsComputer SimulationElectronsModels, TheoreticalMonte Carlo MethodQuality ControlRadiometryRadiotherapy DosageRadiotherapy Planning, Computer-AssistedRadiotherapy, High-EnergySensitivity and SpecificityConceptsFluence profilesVarian Clinac 2100C linear acceleratorElectron radiation therapyElectron beamMonte Carlo methodBeam energyBeam deliveryMonte Carlo investigationElectron beam energyCarlo methodMonte CarloOff-axis locationBEAM codeSigmoid functionLeaf endsEnergy dependenceInverse planning algorithmLinear acceleratorVariable energyMLC aperturesOperatorsBeamField sizeDose distributionMultileaf collimatorA Monte Carlo dose calculation tool for radiotherapy treatment planning
Ma C, Li JS, Pawlicki T, Jiang SB, Deng J, Lee MC, Koumrian T, Luxton M, Brain S. A Monte Carlo dose calculation tool for radiotherapy treatment planning. Physics In Medicine And Biology 2002, 47: 1671-1689. PMID: 12069086, DOI: 10.1088/0031-9155/47/10/305.Peer-Reviewed Original ResearchMeSH KeywordsComputer SimulationHumansMonte Carlo MethodNeoplasmsPhantoms, ImagingRadiotherapy Planning, Computer-AssistedRadiotherapy, Conformal
2001
Monte Carlo based treatment planning for modulated electron beam radiation therapy
Lee M, Deng J, Li J, Jiang S, Ma C. Monte Carlo based treatment planning for modulated electron beam radiation therapy. Physics In Medicine And Biology 2001, 46: 2177-2199. PMID: 11512618, DOI: 10.1088/0031-9155/46/8/310.Peer-Reviewed Original ResearchMeSH KeywordsElectronsMonte Carlo MethodPhantoms, ImagingRadiotherapy DosageRadiotherapy Planning, Computer-AssistedRadiotherapy, High-EnergyReproducibility of ResultsScattering, RadiationConceptsElectron multileaf collimatorIntensity mapsDose distributionElectron radiation therapyElectron beamletsElectron energyElectron beam radiation therapyAir scatteringMonte CarloBremsstrahlung contributionConformal dose distributionsMonte Carlo simulationsBeamletsScatter dosesTreatment planning systemElectronsMultileaf collimatorCarlo simulationsBreast plansIrregular targetsLeaf transportCarloScatteringMonte Carlo generationCollimatorDerivation of electron and photon energy spectra from electron beam central axis depth dose curves
Deng J, Jiang S, Pawlicki T, Li J, Ma C. Derivation of electron and photon energy spectra from electron beam central axis depth dose curves. Physics In Medicine And Biology 2001, 46: 1429-1449. PMID: 11384063, DOI: 10.1088/0031-9155/46/5/308.Peer-Reviewed Original ResearchMeSH KeywordsAlgorithmsElectronsImage Processing, Computer-AssistedLeast-Squares AnalysisMonte Carlo MethodPhotonsRadiotherapy Planning, Computer-AssistedConceptsPhoton energy spectrumDepth dose curvesCentral axis depth dose curvesPhase-space simulationsElectron beamEnergy spectrumDose curvesElectron beam dose calculationsLinear accelerator treatment headCentral axis percentage depth-dose (PDD) curvesPercentage depth dose curvesDerivation of electronPhase space dataClinical electron beamsMeV electron beamSpace simulationTreatment headPDD curvesDose profilesElectronsBeamCorresponding spectraPhotonsDose calculationsSpectraThe MLC tongue-and-groove effect on IMRT dose distributions
Deng J, Pawlicki T, Chen Y, Li J, Jiang S, Ma C. The MLC tongue-and-groove effect on IMRT dose distributions. Physics In Medicine And Biology 2001, 46: 1039-1060. PMID: 11324950, DOI: 10.1088/0031-9155/46/4/310.Peer-Reviewed Original ResearchMeSH KeywordsBone NeoplasmsElectronsHumansMaleMonte Carlo MethodPhotonsProstatic NeoplasmsRadiometryRadiotherapy Planning, Computer-AssistedRadiotherapy, Conformal