1988
LYTIC ANTI-ENDOTHELIAL CELL ANTIBODIES IN HAEMOLYTIC-URAEMIC SYNDROME
Leung D, Havens P, Moake J, Kim M, Pober J. LYTIC ANTI-ENDOTHELIAL CELL ANTIBODIES IN HAEMOLYTIC-URAEMIC SYNDROME. The Lancet 1988, 332: 183-186. PMID: 2899661, DOI: 10.1016/s0140-6736(88)92287-8.Peer-Reviewed Original ResearchConceptsAnti-endothelial cell antibodiesHaemolytic uraemic syndromeThrombotic thrombocytopenic purpuraCell antibodiesComplement-fixing IgGDisorder of immunoregulationAnti-endothelial antibodiesEndothelial cell antigensCultured human umbilical vein endothelial cellsGamma-interferon treatmentHuman umbilical vein endothelial cellsUmbilical vein endothelial cellsAdult patientsVein endothelial cellsThrombocytopenic purpuraIgM antibodiesVascular injuryInterferon treatmentUraemic syndromeGamma interferonCell antigensControl seraEndothelial cellsAntibodiesSerumThree distinct classes of regulatory cytokines control endothelial cell MHC antigen expression. Interactions with immune gamma interferon differentiate the effects of tumor necrosis factor and lymphotoxin from those of leukocyte alpha and fibroblast beta interferons.
Lapierre LA, Fiers W, Pober JS. Three distinct classes of regulatory cytokines control endothelial cell MHC antigen expression. Interactions with immune gamma interferon differentiate the effects of tumor necrosis factor and lymphotoxin from those of leukocyte alpha and fibroblast beta interferons. Journal Of Experimental Medicine 1988, 167: 794-804. PMID: 2450953, PMCID: PMC2188900, DOI: 10.1084/jem.167.3.794.Peer-Reviewed Original ResearchConceptsIFN-alphaIL-6Endothelial cellsClass IAction of lymphotoxinMHC antigen expressionIFN-alpha/betaClass II antigensClass I expressionClass II inductionTumor necrosis factorCultured human endothelial cellsClass I MHCRecombinant preparationsHuman endothelial cellsCytokine administrationMHC antigensII antigensPatient populationRegulatory cytokinesNecrosis factorAntigen expressionGamma interferonIFN-gammaI MHC
1986
Immunoglobulin M antibodies present in the acute phase of Kawasaki syndrome lyse cultured vascular endothelial cells stimulated by gamma interferon.
Leung DY, Collins T, Lapierre LA, Geha RS, Pober JS. Immunoglobulin M antibodies present in the acute phase of Kawasaki syndrome lyse cultured vascular endothelial cells stimulated by gamma interferon. Journal Of Clinical Investigation 1986, 77: 1428-1435. PMID: 3084559, PMCID: PMC424542, DOI: 10.1172/jci112454.Peer-Reviewed Original ResearchConceptsAcute Kawasaki syndromeKawasaki syndromeImmunoglobulin M antibodiesGamma-IFNVein endothelial cellsM antibodiesEndothelial cellsT cellsKS seraGamma interferonClass II major histocompatibility complex antigen expressionMajor histocompatibility complex antigen expressionComplement-dependent cytotoxic activityAnti-endothelial cell antibodiesHUVE cellsHuman dermal fibroblastsHuman saphenous vein smooth muscle cellsSaphenous vein smooth muscle cellsMarked immune activationSecrete gamma interferonSecretion of lymphokinesEndothelial cell antigensAge-matched controlsVein smooth muscle cellsActivated T cells
1983
Ia expression by vascular endothelium is inducible by activated T cells and by human gamma interferon.
Pober JS, Gimbrone MA, Cotran RS, Reiss CS, Burakoff SJ, Fiers W, Ault KA. Ia expression by vascular endothelium is inducible by activated T cells and by human gamma interferon. Journal Of Experimental Medicine 1983, 157: 1339-1353. PMID: 6403654, PMCID: PMC2186979, DOI: 10.1084/jem.157.4.1339.Peer-Reviewed Original ResearchConceptsAllogeneic T cellsT cellsIa antigensEndothelial cellsPeripheral blood mononuclear cellsBlood mononuclear cellsCultured human umbilical vein endothelial cellsExpression of IaActivated T cellsHuman umbilical vein endothelial cellsUmbilical vein endothelial cellsAllograft rejectionVein endothelial cellsGamma interferon geneFluorescence flow cytometryHuman gamma interferonMononuclear cellsImmune responseGamma interferonVascular endotheliumIa expressionFlow cytometryImmune interferonMonoclonal antibodiesAntigen