2024
Exhaled breath analysis: A promising triage test for tuberculosis in young children
Bijker E, Smith J, Mchembere W, McCarthy K, Oord H, Gerritsen J, Click E, Cain K, Song R. Exhaled breath analysis: A promising triage test for tuberculosis in young children. Tuberculosis 2024, 149: 102566. PMID: 39332067, DOI: 10.1016/j.tube.2024.102566.Peer-Reviewed Original ResearchTriage testPaediatric pulmonary tuberculosisRespiratory tract infectionsSymptoms of tuberculosisDiagnose respiratory tract infectionsCross-sectional studyExpectorated sputumTract infectionsPulmonary tuberculosisPaediatric tuberculosisDiagnostic accuracyBreath testYoung childrenYoung infantsTuberculosisExhaled breath analysisBreathingBreath analysisChildrenTriageExhaled breathSputumInfantsFeasibility and utility of a combined nasogastric-tube-and-string-test device for bacteriologic confirmation of pulmonary tuberculosis in young children
Khambati N, Song R, Smith J, Bijker E, McCarthy K, Click E, Mchembere W, Okumu A, Musau S, Okeyo E, Perez-Velez C, Cain K. Feasibility and utility of a combined nasogastric-tube-and-string-test device for bacteriologic confirmation of pulmonary tuberculosis in young children. Diagnostic Microbiology And Infectious Disease 2024, 109: 116302. PMID: 38657352, PMCID: PMC11128341, DOI: 10.1016/j.diagmicrobio.2024.116302.Peer-Reviewed Original Research
2023
Machine learning to predict bacteriologic confirmation of Mycobacterium tuberculosis in infants and very young children
Smith J, Milligan K, McCarthy K, Mchembere W, Okeyo E, Musau S, Okumu A, Song R, Click E, Cain K. Machine learning to predict bacteriologic confirmation of Mycobacterium tuberculosis in infants and very young children. PLOS Digital Health 2023, 2: e0000249. PMID: 37195976, PMCID: PMC10191346, DOI: 10.1371/journal.pdig.0000249.Peer-Reviewed Original ResearchMicrobial confirmationTB diseaseYoung childrenNoninvasive procedureLarge prospective cohortCases of tuberculosisChest X-rayDiagnosis of tuberculosisClinical decision makingBacteriologic confirmationHousehold contactsTB infectionProspective cohortRadiologic factorsPaucibacillary natureClinical similaritiesDiagnostic cohortClinical diseaseChildhood diseasesInvasive proceduresNovel biomarkersTuberculosisClinical researchM. tuberculosisDiseaseRetaining Patients with Drug-Resistant Tuberculosis on Treatment During the COVID-19 Pandemic — Dharavi, Mumbai, India, 2020–2022
Gomare M, Bhide S, Deshmukh R, Kaipilyawar S, Puri V, Moonan P, Khetade D, Nyendak M, Yeldandi V, Smith J, Tobias J, Date A, Joshi R, Kumar R, Ho C. Retaining Patients with Drug-Resistant Tuberculosis on Treatment During the COVID-19 Pandemic — Dharavi, Mumbai, India, 2020–2022. MMWR Morbidity And Mortality Weekly Report 2023, 72: 304-308. PMID: 36952291, PMCID: PMC10042620, DOI: 10.15585/mmwr.mm7212a2.Peer-Reviewed Original Research
2022
Clinical and Radiologic Factors Associated With Detection of Mycobacterium tuberculosis in Children Under 5 Years old Using Invasive and Noninvasive Sample Collection Techniques—Kenya
Smith J, Song R, McCarthy K, Mchembere W, Click E, Cain K. Clinical and Radiologic Factors Associated With Detection of Mycobacterium tuberculosis in Children Under 5 Years old Using Invasive and Noninvasive Sample Collection Techniques—Kenya. Open Forum Infectious Diseases 2022, 9: ofac560. PMID: 36386048, PMCID: PMC9664973, DOI: 10.1093/ofid/ofac560.Peer-Reviewed Original ResearchSpecimen collection techniquesRadiologic factorsYoung childrenProspective cohort studyFine-needle aspirationHistory of exposurePublic health concernCritical public health concernBacteriologic confirmationAirway compressionCervical lymphadenopathyRadiological factorsCohort studyPediatric tuberculosisTB casesPresumptive tuberculosisClinical managementImmunologic evidenceNeedle aspirationPositive specimenDiagnostic testingTuberculosisLogistic regressionHealth concernMycobacterium tuberculosisZambia Assessment of Tuberculosis (TB) and HIV in the Mines (ZATHIM): implications for programs and policies
Podewils LJ, Long EF, Fuller TJ, Mwakazanga D, Kapungu K, Tembo M, Mwanza S, Curran KG, Smith JP, Tobias JL, Kasongo W. Zambia Assessment of Tuberculosis (TB) and HIV in the Mines (ZATHIM): implications for programs and policies. BMC Public Health 2022, 22: 791. PMID: 35439984, PMCID: PMC9018205, DOI: 10.1186/s12889-022-13053-8.Peer-Reviewed Original ResearchConceptsHealthcare workersTB symptomsMore TB symptomsFocus group discussionsDiagnosis of tuberculosisTB diseaseTB careTB statusMixed-method evaluationAppropriate careKey populationsReporting 2TuberculosisKAP surveyAssess knowledgeHigh-quality healthcare servicesHealthcare servicesCareHealthy livingHIVHigh rateSymptomsDiagnosisMajor barrierCurrent evaluation
2015
Why healthcare workers are sick of TB
von Delft A, Dramowski A, Khosa C, Kotze K, Lederer P, Mosidi T, Peters JA, Smith J, van der Westhuizen HM, von Delft D, Willems B, Bates M, Craig G, Maeurer M, Marais BJ, Mwaba P, Nunes EA, Nyirenda T, Oliver M, Zumla A. Why healthcare workers are sick of TB. International Journal Of Infectious Diseases 2015, 32: 147-151. PMID: 25809771, DOI: 10.1016/j.ijid.2014.12.003.Peer-Reviewed Original ResearchConceptsDrug-resistant tuberculosisInfection control measuresHealthcare workersLife-threatening diagnosisRisk of tuberculosisOccupational tuberculosisTB diseaseTreatment optionsTB epidemicPrevalent exposureHealthcare colleaguesHealthcare resourcesUrgent interventionTuberculosisControl measuresInterventionPervasive stigmatizationFront-line workersDiseaseDiagnosisWorkers
2013
Aspiring to Zero Tuberculosis Deaths among Southern Africa's Miners: Is There a Way Forward?
Dharmadhikari A, Smith J, Nardell E, Churchyard G, Keshavjee S. Aspiring to Zero Tuberculosis Deaths among Southern Africa's Miners: Is There a Way Forward? International Journal Of Social Determinants Of Health And Health Services 2013, 43: 651-664. PMID: 24397232, DOI: 10.2190/hs.43.4.d.Peer-Reviewed Original ResearchMeSH KeywordsAfrica, SouthernComorbidityDisease ProgressionEarly DiagnosisHIV InfectionsHousingHumansImmunocompromised HostLatent TuberculosisMaleMiningOccupational DiseasesOccupational Health ServicesSecondary PreventionSilicosisSocial ConditionsTuberculosisTuberculosis, Multidrug-ResistantWorkforceConceptsTuberculosis notification ratesNotification ratesDrug-resistant strainsSpread of tuberculosisHigh rateTuberculosis deathsActive tuberculosisHIV infectionSouth African minersImmediate treatmentTuberculosis diseaseConcurrent treatmentTuberculosis mortalityGeneral populationAppropriate managementTuberculosisSilica dustActive casesBiomedical interventionsDiseaseDeathAirborne diseasesInfectionPoor workingAfrican miners
2011
Nanoparticle delivery of anti-tuberculosis chemotherapy as a potential mediator against drug-resistant tuberculosis.
Smith JP. Nanoparticle delivery of anti-tuberculosis chemotherapy as a potential mediator against drug-resistant tuberculosis. The Yale Journal Of Biology And Medicine 2011, 84: 361-9. PMID: 22180674, PMCID: PMC3238330.Peer-Reviewed Original ResearchConceptsDrug-resistant tuberculosisCurrent chemotherapyAnti-TB drug candidatesAnti-tuberculosis chemotherapyDuration of treatmentDrug-resistant strainsGlobal health communityPill burdenPatient adherenceTuberculosis chemotherapyChemotherapyDrug resistanceIncomplete treatmentPotential mediatorsHealth communityNanoparticle drug deliveryTuberculosisDrug candidatesDevelopment pipelineNanoparticle deliveryTreatmentDeliveryDrug delivery