2005
Mitochondrial DNA depletion analysis by pseudogene ratioing
Swerdlow R, Redpath G, Binder D, Davis J, VandenBerg S. Mitochondrial DNA depletion analysis by pseudogene ratioing. Journal Of Neuroscience Methods 2005, 150: 265-271. PMID: 16118020, DOI: 10.1016/j.jneumeth.2005.06.023.Peer-Reviewed Original ResearchConceptsPlasmid clonesCell linesTreated with ethidium bromideCopies of mtDNAPolymerase chain reactionMtDNA copy numberPCR-based analysisPolymerase chain reaction productsU251 human glioma cell lineMtDNA pseudogenesAmplified mtDNAMitochondrial DNAMtDNAMtDNA depletionGenomic DNACopy numberHuman glioma cell linesPseudogenesGlioma cell linesEthidium bromidePrimersPlasmidClonesDNAChain reaction
1999
Parkinson Disease in Twins
Parker W, Swerdlow R, Parks J, Davis J, Trimmer P, Bennett J, Wooten G. Parkinson Disease in Twins. JAMA 1999, 282: 1328-1329. PMID: 10527169, DOI: 10.1001/jama.282.14.1328.Peer-Reviewed Original Research
1998
Matrilineal inheritance of complex I dysfunction in a multigenerational Parkinson's disease family
Swerdlow R, Parks J, Davis J, Cassarino D, Trimmer P, Currie L, Dougherty J, Bridges W, Bennett J, Wooten G, Parker W. Matrilineal inheritance of complex I dysfunction in a multigenerational Parkinson's disease family. Annals Of Neurology 1998, 44: 873-881. PMID: 9851431, DOI: 10.1002/ana.410440605.Peer-Reviewed Original ResearchConceptsCybrid linesMaternal descendantsComplex I dysfunctionInherited mtDNA mutationsCybrid cell linesIncreased reactive oxygen species productionReactive oxygen species productionComplex I activityMitochondrial DNAMtDNA mutationsHuman neuroblastoma cellsFamily membersMitochondrial morphologyMtDNACytoplasmic hybridsPaternal descendantsOxygen species productionCybridsGenetic lesionsMatrilineal inheritanceMaternal lineMultiple membersI activityNeuroblastoma cellsEnzyme activityEvidence That Two Reports of mtDNA Cytochrome c Oxidase “Mutations” in Alzheimer's Disease Are Based on nDNA Pseudogenes of Recent Evolutionary Origin
Davis J, Parker W. Evidence That Two Reports of mtDNA Cytochrome c Oxidase “Mutations” in Alzheimer's Disease Are Based on nDNA Pseudogenes of Recent Evolutionary Origin. Biochemical And Biophysical Research Communications 1998, 244: 877-883. PMID: 9535760, DOI: 10.1006/bbrc.1998.8353.Peer-Reviewed Original ResearchConceptsEvolutionary originAmplification of nuclear DNACytochrome c oxidase subunitEtiology of Alzheimer's diseaseHeteroplasmic mitochondrial DNAAlzheimer's diseaseMtDNA pseudogenesMitochondrial DNAPCR artifactsNuclear DNASequence variabilityMtDNAPseudogenesNT2 cellsHigher abundanceMutationsAlzheimer's disease subjectsDNAAlzheimerNDNAGenesSubunitSequencePCRAbundance