A critical role for NMDA receptors in parvalbumin interneurons for gamma rhythm induction and behavior
Carlén M, Meletis K, Siegle J, Cardin J, Futai K, Vierling-Claassen D, Rühlmann C, Jones S, Deisseroth K, Sheng M, Moore C, Tsai L. A critical role for NMDA receptors in parvalbumin interneurons for gamma rhythm induction and behavior. Molecular Psychiatry 2011, 17: 537-548. PMID: 21468034, PMCID: PMC3335079, DOI: 10.1038/mp.2011.31.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAssociation LearningBrain WavesConditioning, PsychologicalExcitatory Postsynaptic PotentialsGABA AntagonistsGABAergic NeuronsInterneuronsMaleMaze LearningMemory, Short-TermMiceMice, TransgenicParvalbuminsPhotic StimulationPicrotoxinReceptors, N-Methyl-D-AspartateSensory GatingStereotyped BehaviorConceptsGamma oscillationsSpecific cognitive behaviorSelective cognitive impairmentsGamma rhythmsPsychosis-like symptomsCognitive tasksAssociative learningNeural network dysfunctionCognitive behaviorCortical gamma rhythmsCognitive impairmentNetwork dysfunctionNMDAR neurotransmissionOptogenetic drivePV interneuronsParvalbumin interneuronsNMDAR antagonistsMemoryReduced sensitivityBehaviorTaskHabituationDeficitsNormal behaviorLearning