2016
Toward Repurposing Metformin as a Precision Anti-Cancer Therapy Using Structural Systems Pharmacology
Hart T, Dider S, Han W, Xu H, Zhao Z, Xie L. Toward Repurposing Metformin as a Precision Anti-Cancer Therapy Using Structural Systems Pharmacology. Scientific Reports 2016, 6: 20441. PMID: 26841718, PMCID: PMC4740793, DOI: 10.1038/srep20441.Peer-Reviewed Original ResearchConceptsPrecision anti-cancer therapyMolecular basisAnti-cancer therapyStructural systems pharmacologyProtein-protein interactionsDrug target identificationNetwork biology analysisMolecular targetsInteractomic dataGenetic interactionsStructural proteomeGenetic networksKey molecular targetsPhenotypic responsesKinase targetsBiology analysisCancer mutationsPleiotropic effectsAnti-cancer effectsNetwork biomarkersTarget identificationGenetic biomarkersSystems pharmacology approachKey nodesTarget
2015
Oncogenes and tumor suppressor genes: comparative genomics and network perspectives
Zhu K, Liu Q, Zhou Y, Tao C, Zhao Z, Sun J, Xu H. Oncogenes and tumor suppressor genes: comparative genomics and network perspectives. BMC Genomics 2015, 16: s8. PMID: 26099335, PMCID: PMC4474543, DOI: 10.1186/1471-2164-16-s7-s8.Peer-Reviewed Original ResearchConceptsTumor suppressor geneEssential genesTSG proteinsEssential proteinsHuman protein-protein interaction networkCancer drug target proteinsSuppressor geneWhole human interactomeProtein-protein interaction networkCancer developmentMutation frequencyDirect interactionDrug target identificationCancer drug targetSomatic mutationsDrug target proteinsDrug target genesComparative genomicsLow mutation frequencyCellular functionsHuman interactomeMutation patternsGenetic variationGene setsHigh mutation frequency
2014
Integrative Genomics and Computational Systems Medicine
McDermott J, Huang Y, Zhang B, Xu H, Zhao Z. Integrative Genomics and Computational Systems Medicine. BioMed Research International 2014, 2014: 945253. PMID: 25025078, PMCID: PMC4082850, DOI: 10.1155/2014/945253.Peer-Reviewed Original Research
2013
Interdisciplinary dialogue for education, collaboration, and innovation: Intelligent Biology and Medicine in and beyond 2013
Zhang B, Huang Y, McDermott J, Posey R, Xu H, Zhao Z. Interdisciplinary dialogue for education, collaboration, and innovation: Intelligent Biology and Medicine in and beyond 2013. BMC Genomics 2013, 14: s1. PMID: 24564388, PMCID: PMC4042234, DOI: 10.1186/1471-2164-14-s8-s1.Peer-Reviewed Original Research
2012
Advances in systems biology: computational algorithms and applications
Huang Y, Zhao Z, Xu H, Shyr Y, Zhang B. Advances in systems biology: computational algorithms and applications. BMC Systems Biology 2012, 6: s1. PMID: 23281622, PMCID: PMC3524016, DOI: 10.1186/1752-0509-6-s3-s1.Peer-Reviewed Original ResearchGenomics in 2012: challenges and opportunities in the next generation sequencing era
Zhao Z, Huang Y, Zhang B, Shyr Y, Xu H. Genomics in 2012: challenges and opportunities in the next generation sequencing era. BMC Genomics 2012, 13: s1. PMID: 23281891, PMCID: PMC3535713, DOI: 10.1186/1471-2164-13-s8-s1.Peer-Reviewed Original Research
2011
The Emerging Role of Electronic Medical Records in Pharmacogenomics
Wilke R, Xu H, Denny J, Roden D, Krauss R, McCarty C, Davis R, Skaar T, Lamba J, Savova G. The Emerging Role of Electronic Medical Records in Pharmacogenomics. Clinical Pharmacology & Therapeutics 2011, 89: 379-386. PMID: 21248726, PMCID: PMC3204342, DOI: 10.1038/clpt.2010.260.Peer-Reviewed Original Research
2006
Natural language processing and visualization in the molecular imaging domain
Tulipano P, Tao Y, Millar W, Zanzonico P, Kolbert K, Xu H, Yu H, Chen L, Lussier Y, Friedman C. Natural language processing and visualization in the molecular imaging domain. Journal Of Biomedical Informatics 2006, 40: 270-281. PMID: 17084109, DOI: 10.1016/j.jbi.2006.08.002.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell LineComputational BiologyDatabases, BibliographicDatabases, GeneticDiagnostic ImagingGenomicsHumansInformation Storage and RetrievalNatural Language ProcessingPhenotypeProgramming LanguagesSoftwareSystems IntegrationTerminology as TopicUser-Computer InterfaceVocabulary, ControlledConceptsImaging domainNatural language processing systemsNatural language processingLanguage processing systemJava viewerNLP systemsFormal evaluation studiesLanguage processingInformation resourcesProcessing systemMedical imagingIndex imagesSystem performanceBiological informationInformationImagesVisualizationBioMedLEEPerformanceNLPEvaluation studyDomainGenomics literatureSystemSimultaneous visualization