2021
Inhibition of T-Cells by Cyclosporine A Reduces Macrophage Accumulation to Regulate Venous Adaptive Remodeling and Increase Arteriovenous Fistula Maturation
Matsubara Y, Kiwan G, Liu J, Gonzalez L, Langford J, Gao M, Gao X, Taniguchi R, Yatsula B, Furuyama T, Matsumoto T, Komori K, Dardik A. Inhibition of T-Cells by Cyclosporine A Reduces Macrophage Accumulation to Regulate Venous Adaptive Remodeling and Increase Arteriovenous Fistula Maturation. Arteriosclerosis Thrombosis And Vascular Biology 2021, 41: e160-e174. PMID: 33472405, PMCID: PMC7904667, DOI: 10.1161/atvbaha.120.315875.Peer-Reviewed Original ResearchConceptsVascular wall thickeningT helper type 1 (Th1) cellsSuccessful AVF maturationAVF maturationRegulatory T cellsMacrophage accumulationT cellsType 1 cellsArteriovenous fistulaVenous remodelingWall thickeningMouse aortocaval fistula modelT helper type 2T helper type 2 cellsAdaptive remodelingM2 macrophage accumulationPrimary success rateAortocaval fistula modelArteriovenous fistula maturationPreferred vascular accessAnti-inflammatory macrophagesT cell functionWild-type miceEffect of CsAType 2 cells
2020
Distinct subsets of T cells and macrophages impact venous remodeling during arteriovenous fistula maturation
Matsubara Y, Kiwan G, Fereydooni A, Langford J, Dardik A. Distinct subsets of T cells and macrophages impact venous remodeling during arteriovenous fistula maturation. JVS Vascular Science 2020, 1: 207-218. PMID: 33748787, PMCID: PMC7971420, DOI: 10.1016/j.jvssci.2020.07.005.Peer-Reviewed Original ResearchArteriovenous fistulaT cellsVascular remodelingAVF maturationFistula maturationVascular accessEnd-stage renal failureImmunosuppressive drug developmentInflammatory cell subsetsPatent vascular accessArterial blood pressureArteriovenous fistula maturationPreferred vascular accessRegulation of inflammationPrimary patencyTotal immunosuppressionAdaptive vascular remodelingRenal transplantationRenal failureBlood pressureCell subsetsVenous remodelingLonger patencyM2 macrophagesNeointimal hyperplasia