2021
Optimal Biomechanical Parameters for Measuring Sclerotic Chronic Graft-Versus-Host Disease
Baker L, Chen F, Cronin A, Chen H, Vain A, Jagasia M, Tkaczyk E. Optimal Biomechanical Parameters for Measuring Sclerotic Chronic Graft-Versus-Host Disease. JID Innovations 2021, 1: 100037. PMID: 34790906, PMCID: PMC8594905, DOI: 10.1016/j.xjidi.2021.100037.Peer-Reviewed Original ResearchCGVHD patientsBiomechanical parametersChronic Graft-VersusSclerotic chronic graftHost disease patientsBackward stepwise selectionChronic graftGraft-VersusSclerotic cGvHDHost diseaseUnivariable analysisTransplant controlsDisease patientsAnatomic sitesPatientsDisease severityLogistic regressionSclerotic diseaseBiomechanical studyDiscriminatory abilityLASSO regressionCharacteristic curveMyotonometerStepwise selectionDisease
2019
Interobserver Reproducibility of the Myoton and Durometer Devices to Measure Skin Stiffness and Hardness in Chronic Cutaneous Graft-Versus-Host Disease Patients
Chen F, Wang L, Vain A, Ssempijja Y, Dellalana L, Zhang K, Hood A, Chen H, Jagasia M, Tkaczyk E. Interobserver Reproducibility of the Myoton and Durometer Devices to Measure Skin Stiffness and Hardness in Chronic Cutaneous Graft-Versus-Host Disease Patients. Blood 2019, 134: 4515. DOI: 10.1182/blood-2019-129125.Peer-Reviewed Original ResearchIntraclass correlation coefficientCGVHD patientsInterobserver intraclass correlation coefficientSkin stiffness measurementsCutaneous cGVHDInterobserver reproducibilityChronic cutaneous graftCutaneous Graft-VersusHealth Chronic GraftSkin stiffnessHost disease patientsProgression of sclerosisStiffness measurementLongitudinal studyProspective longitudinal studyMinimal detectable changeTherapeutic response measuresDetectable changeChronic graftGraft-VersusHost diseaseSclerotic cGvHDSkin sclerosisCutaneous graftDisease patientsDiagnostic Potential of Five Different Biomechanical Parameters to Detect Sclerotic Cutaneous Graft-Versus-Host Disease
Chen F, Wang L, Ssempijja Y, Vain A, Jagasia M, Tkaczyk E. Diagnostic Potential of Five Different Biomechanical Parameters to Detect Sclerotic Cutaneous Graft-Versus-Host Disease. Blood 2019, 134: 2002. DOI: 10.1182/blood-2019-129381.Peer-Reviewed Original ResearchCGVHD patientsBMT controlsCross-sectional studyHost diseaseSkin sclerosisSkin scoreBiomechanical parametersSclerotic patientsCutaneous Graft-VersusPost-BMT patientsMechanical stress relaxation timeHigh diagnostic yieldProspective longitudinal studyChronic graftGraft-VersusGVHD patientsSkin involvementUnaffected skinUnivariate analysisHealthy controlsMultivariate predictive modelClinician assessmentDiagnostic yieldTreatment responseResponse assessmentCrowdsourcing to delineate skin affected by chronic graft‐vs‐host disease
Tkaczyk E, Coco J, Wang J, Chen F, Ye C, Jagasia M, Dawant B, Fabbri D. Crowdsourcing to delineate skin affected by chronic graft‐vs‐host disease. Skin Research And Technology 2019, 25: 572-577. PMID: 30786065, PMCID: PMC6719554, DOI: 10.1111/srt.12688.Peer-Reviewed Original ResearchConceptsChronic graftHost diseaseAffected skinPercent body surface areaBody surface areaBoard-certified dermatologistsCurrent clinical standardMedian Dice indexCGVHD patientsPrimary outcomeImportant unmetAffected surface areaThree-dimensional photographsClinical standardsFleiss' kappaDiseaseSkinGraftPractical managementWeak correlationHigh agreementKappaConsensus delineationPatients
2018
Non-invasive measurement of sclerosis in cutaneous cGVHD patients with the handheld device Myoton: a cross-sectional study
Chen F, Dellalana L, Gandelman J, Vain A, Jagasia M, Tkaczyk E. Non-invasive measurement of sclerosis in cutaneous cGVHD patients with the handheld device Myoton: a cross-sectional study. Bone Marrow Transplantation 2018, 54: 616-619. PMID: 30287938, PMCID: PMC6872187, DOI: 10.1038/s41409-018-0346-7.Peer-Reviewed Original ResearchSegmentation of skin lesions in chronic graft versus host disease photographs with fully convolutional networks
Wang J, Chen F, Dellalana L, Jagasia M, Tkaczyk E, Dawant B. Segmentation of skin lesions in chronic graft versus host disease photographs with fully convolutional networks. 2018, 10575: 105750n. DOI: 10.1117/12.2293334.Peer-Reviewed Original ResearchBody surface areaHematopoietic stem cell transplantationSkin lesionsChronic graftHost diseaseAllogeneic hematopoietic stem cell transplantationInvolved body surface areaSeverity of cGVHDLife-threatening complicationsStem cell transplantationCGVHD patientsCell transplantationPatient morbidityLesionsPatientsSerial photographyCGVHDGraftDiseaseSkinPreliminary studyEncouraging resultsMorbidityComplicationsTransplantation