2016
Interaction of Tumor Necrosis Factor Receptor-associated Factor 6 (TRAF6) and Vav3 in the Receptor Activator of Nuclear Factor κB (RANK) Signaling Complex Enhances Osteoclastogenesis*
Yu J, Yun H, Shin B, Kim Y, Park E, Choi S, Yu J, Amarasekara D, Kim S, Inoue J, Walsh M, Choi Y, Takami M, Rho J. Interaction of Tumor Necrosis Factor Receptor-associated Factor 6 (TRAF6) and Vav3 in the Receptor Activator of Nuclear Factor κB (RANK) Signaling Complex Enhances Osteoclastogenesis*. Journal Of Biological Chemistry 2016, 291: 20643-20660. PMID: 27507811, PMCID: PMC5034056, DOI: 10.1074/jbc.m116.728303.Peer-Reviewed Original ResearchConceptsTNF receptor-associated factor 6Signaling complexIVVY motifCross-talkDbl homology domainCoiled-coil domainFactor 6RANK-mediated osteoclastogenesisTRAF6-binding siteFunctional cross-talkUbiquitin pathwayBinding partnersCytoplasmic tailTumor necrosis factor receptor-associated factor 6Activation of nuclear factor-kBInteraction partnersNuclear factor-kBProteomic approachVav3Signaling cascadesFunctional importanceMotifCooperative signalingMutantsInteraction of tumor necrosis factor receptor-associated factor 6
2012
D-chiro-inositol Negatively Regulates the Formation of Multinucleated Osteoclasts by Down-Regulating NFATc1
Yu J, Choi S, Park E, Shin B, Yu J, Lee S, Takami M, Kang J, Meong H, Rho J. D-chiro-inositol Negatively Regulates the Formation of Multinucleated Osteoclasts by Down-Regulating NFATc1. Journal Of Clinical Immunology 2012, 32: 1360-1371. PMID: 22711011, DOI: 10.1007/s10875-012-9722-z.Peer-Reviewed Original ResearchConceptsTartrate-resistant acid phosphataseEffect of D-chiro-inositolOC differentiationD-chiro-inositolExpression of OC marker genesNuclear factor of activated T cells c1Inflammatory bone lossCell-cell fusionAccelerated bone destructionDose-dependent mannerExpression of NFATc1Formation of multinucleated osteoclastsBone-related diseasesMultinucleated giant cellsSecondary osteoporosisCell fusion assayOsteoclastogenic genesBone destructionBone lossDiabetes mellitusOC precursorsGiant cellsOC formationMultinucleated osteoclastsNFATc1
2009
Protein arginine methyltransferase 1 regulates herpes simplex virus replication through ICP27 RGG-box methylation
Yu J, Shin B, Park E, Yang S, Choi S, Kang M, Rho J. Protein arginine methyltransferase 1 regulates herpes simplex virus replication through ICP27 RGG-box methylation. Biochemical And Biophysical Research Communications 2009, 391: 322-328. PMID: 19913501, DOI: 10.1016/j.bbrc.2009.11.057.Peer-Reviewed Original ResearchConceptsProtein arginine methyltransferase 1ICP27 RGG boxProtein arginine methylationArginine methylationRGG boxHerpes simplex virus type 1Arginine residuesRNA-binding activityArginine substitution mutantsArginine methyltransferase 1Gene expression in vivoRNA metabolismMethylation sitesSubcellular localizationSubstitution mutantsCellular processesCellular regulationExpression in vivoHerpes simplex virus replicationArginine mutationPRMT inhibitorsICP27Methyltransferase 1Cytokine signalingCellular mediators