2014
Secretion of a Truncated Osteopetrosis-associated Transmembrane Protein 1 (OSTM1) Mutant Inhibits Osteoclastogenesis through Down-regulation of the B Lymphocyte-induced Maturation Protein 1 (BLIMP1)-Nuclear Factor of Activated T Cells c1 (NFATc1) Axis*
Shin B, Yu J, Park E, Choi S, Yu J, Hwang J, Yun H, Chung Y, Hong K, Choi J, Takami M, Rho J. Secretion of a Truncated Osteopetrosis-associated Transmembrane Protein 1 (OSTM1) Mutant Inhibits Osteoclastogenesis through Down-regulation of the B Lymphocyte-induced Maturation Protein 1 (BLIMP1)-Nuclear Factor of Activated T Cells c1 (NFATc1) Axis*. Journal Of Biological Chemistry 2014, 289: 35868-35881. PMID: 25359771, PMCID: PMC4276856, DOI: 10.1074/jbc.m114.589614.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBone ResorptionCell DifferentiationCell FusionCell SurvivalCells, CulturedDown-RegulationGene ExpressionLipopolysaccharidesMaleMembrane ProteinsMice, Inbred C57BLNFATC Transcription FactorsOsteoclastsOsteoporosisPositive Regulatory Domain I-Binding Factor 1Signal TransductionTranscription FactorsConceptsSecreted formTransmembrane domainOsteopetrosis-associated transmembrane protein 1Down-regulationAutosomal recessive osteopetrosis patientsTransmembrane protein 1Marker genesCell surfaceActivated T cells c1Genetic defectsExpression of OC marker genesCell fusionFunctional roleGenetic mutationsAutosomal recessive osteopetrosisMutationsProtein 1Bone destruction in vivoGene mutationsGenesDestruction in vivoRecessive osteopetrosisOsteoclast (OCOsteopetrosis patientsOsteoclastogenic genes
2008
NHE10, a novel osteoclast-specific member of the Na+/H+ exchanger family, regulates osteoclast differentiation and survival
Lee S, Kim T, Park E, Yang S, Jeong D, Choi Y, Rho J. NHE10, a novel osteoclast-specific member of the Na+/H+ exchanger family, regulates osteoclast differentiation and survival. Biochemical And Biophysical Research Communications 2008, 369: 320-326. PMID: 18269914, DOI: 10.1016/j.bbrc.2008.01.168.Peer-Reviewed Original ResearchConceptsFull-length cDNANa(+)/H(+) exchangerIsolated full-length cDNAsMembrane-spanning domainsNa(+)/H(+) exchanger familyGene expression profilesResponse to receptor activationGene candidatesOC differentiationCDNA microarrayNa+/H+ exchanger familyClonesLigand signalingFunctional roleCDNAAction of osteoblastsRegulates osteoclast differentiationGenesReceptor activationOsteoclast differentiationBone homeostasisDifferentiationBalanced actionOsteoclastsSurvival