2013
Multiple Transcription Factor Binding Sites Predict AID Targeting in Non-Ig Genes
Duke JL, Liu M, Yaari G, Khalil AM, Tomayko MM, Shlomchik MJ, Schatz DG, Kleinstein SH. Multiple Transcription Factor Binding Sites Predict AID Targeting in Non-Ig Genes. The Journal Of Immunology 2013, 190: 3878-3888. PMID: 23514741, PMCID: PMC3689293, DOI: 10.4049/jimmunol.1202547.Peer-Reviewed Original ResearchConceptsTranscription Factor Binding SitesAID-induced lesionsNon-Ig genesGenome instabilityTranscription factorsAberrant targetingSequence dataCertain genesGenesAID targetingGerminal center B cellsSomatic mutationsLikely targetBinding sitesAID targetsTargetingClassification tree modelMistargetingB cellsLociMechanismTargetMutationsSites
2012
Clonal allelic predetermination of immunoglobulin-κ rearrangement
Farago M, Rosenbluh C, Tevlin M, Fraenkel S, Schlesinger S, Masika H, Gouzman M, Teng G, Schatz D, Rais Y, Hanna JH, Mildner A, Jung S, Mostoslavsky G, Cedar H, Bergman Y. Clonal allelic predetermination of immunoglobulin-κ rearrangement. Nature 2012, 490: 561-565. PMID: 23023124, DOI: 10.1038/nature11496.Peer-Reviewed Original Research
2006
AID and Igh switch region-Myc chromosomal translocations
Unniraman S, Schatz DG. AID and Igh switch region-Myc chromosomal translocations. DNA Repair 2006, 5: 1259-1264. PMID: 16784901, DOI: 10.1016/j.dnarep.2006.05.019.Peer-Reviewed Original Research
1996
Transient restoration of gene rearrangement at multiple T cell receptor loci in gamma-irradiated scid mice.
Livák F, Welsh SC, Guidos CJ, Crispe IN, Danska JS, Schatz DG. Transient restoration of gene rearrangement at multiple T cell receptor loci in gamma-irradiated scid mice. Journal Of Experimental Medicine 1996, 184: 419-428. PMID: 8760795, PMCID: PMC2192694, DOI: 10.1084/jem.184.2.419.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, NewbornBase SequenceFemaleGamma RaysGene Rearrangement, alpha-Chain T-Cell Antigen ReceptorGene Rearrangement, delta-Chain T-Cell Antigen ReceptorMaleMiceMice, Inbred AKRMice, Inbred BALB CMice, Inbred C57BLMice, SCIDMolecular Sequence DataReceptors, Antigen, T-CellRecombination, GeneticRestriction MappingThymus Gland
1991
The recombination activating gene-1 (RAG-1) transcript is present in the murine central nervous system
Chun J, Schatz D, Oettinger M, Jaenisch R, Baltimore D. The recombination activating gene-1 (RAG-1) transcript is present in the murine central nervous system. Cell 1991, 64: 189-200. PMID: 1986864, DOI: 10.1016/0092-8674(91)90220-s.Peer-Reviewed Original ResearchMeSH KeywordsAgingAnimalsBase SequenceBrainCell DivisionCell LineChromosome MappingCytarabineGenesMiceMice, Inbred BALB CMolecular Sequence DataNeuronsNucleic Acid HybridizationOligonucleotide ProbesOrgan SpecificityPolymerase Chain ReactionRecombination, GeneticRNA ProbesTeratomaTranscription, GeneticTretinoinConceptsCentral nervous systemRAG-1 transcriptsMurine central nervous systemNervous systemHigh neuronal cell densityRAG-2 transcriptsSite-specific recombination machineryNeuronal cell densityNorthern blot analysisRecombination machineryGenome sitesPolymerase chain reactionRAG-2Postnatal brainPostnatal neuronsDetrimental alterationsRAG-1TranscriptsSitu hybridizationBlot analysisChain reactionNeuronsCell densityRecombination