David R. Martinez, PhD
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Assistant Professor
Biography
David R. Martinez, Ph.D. studies immunity to viral pathogens of global health importance. David grew up in El Salvador until age 13. As a young child, David became interested in emerging viruses because of innate curiosity in viruses and vaccines as well as his exposure to public health campaigns to fight arthropod-borne viruses (e.g., Dengue virus) and other infectious diseases. David received his Ph.D. from Duke University and trained with leading vaccine immunologist, Dr. Sallie R. Permar, at the Duke Human Vaccine Institute. Following the completion of his doctoral studies, David trained as a postdoctoral scholar with one of the world’s leading coronavirologists, Dr. Ralph Baric, at UNC Chapel Hill before and during the COVID-19 pandemic studying immunity to flaviviruses and coronaviruses. Dr. Martinez was part of the teams that contributed to the development of the FDA-approved and widely used Moderna COVID-19 vaccine and the Johnson & Johnson COVID-19 vaccine which was used under Emergency Use Authorization. Dr. Martinez also contributed to the pre-clinical development of COVID-19 human monoclonal antibody therapies from Eli Lilly and AstraZeneca which also received FDA Emergency Use Authorization. Dr. Martinez is a Hanna H. Gray Faculty Fellow of the Howard Hughes Medical Institute.
Appointments
Immunobiology
Assistant ProfessorPrimary
Other Departments & Organizations
Education & Training
- Postdoctoral Scholar
- University of North Carolina at Chapel Hill (2023)
- PhD
- Duke University, Molecular Genetics and Microbiology (2018)
- BS
- University of Oklahoma, Microbiology (2013)
Research
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Overview
Medical Research Interests
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ORCID
0000-0002-2940-8961The Martinez laboratory
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Research at a Glance
Publications Timeline
Research Interests
Dengue Vaccines
Publications
Featured Publications
Chimeric spike mRNA vaccines protect against Sarbecovirus challenge in mice.
Martinez DR, Schäfer A, Leist SR, De la Cruz G, West A, Atochina-Vasserman EN, Lindesmith LC, Pardi N, Parks R, Barr M, Li D, Yount B, Saunders KO, Weissman D, Haynes BF, Montgomery SA, Baric RS. Chimeric spike mRNA vaccines protect against Sarbecovirus challenge in mice. Science 2021, 373: 991-998. PMID: 34214046, DOI: 10.1126/science.abi4506.Peer-Reviewed Original ResearchFc Characteristics Mediate Selective Placental Transfer of IgG in HIV-Infected Women.
Martinez DR, Fong Y, Li SH, Yang F, Jennewein MF, Weiner JA, Harrell EA, Mangold JF, Goswami R, Seage GR 3rd, Alter G, Ackerman ME, Peng X, Fouda GG, Permar SR. Fc Characteristics Mediate Selective Placental Transfer of IgG in HIV-Infected Women. Cell 2019, 178: 190-201.e11. PMID: 31204101, DOI: 10.1016/j.cell.2019.05.046.Peer-Reviewed Original Research
2025
B cells and dengue: A cat-and-mouse game.
Dixit K, Martinez D. B cells and dengue: A cat-and-mouse game. Science Immunology 2025, 10: eaed4909. PMID: 41202147, DOI: 10.1126/sciimmunol.aed4909.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsComing of age: mRNA vaccines for orthoflaviviruses
Akther F, Pardi N, Martinez D. Coming of age: mRNA vaccines for orthoflaviviruses. Trends In Immunology 2025 PMID: 41198509, DOI: 10.1016/j.it.2025.10.005.Peer-Reviewed Original ResearchCitationsAltmetricNonstabilized SARS-CoV-2 spike mRNA vaccination induces broadly neutralizing antibodies in nonhuman primates
Malewana R, Stalls V, May A, Lu X, Martinez D, Schäfer A, Li D, Barr M, Sutherland L, Lee E, Parks R, Beck W, Newman A, Bock K, Minai M, Nagata B, DeMarco C, Denny T, Oguin T, Rountree W, Wang Y, Mansouri K, Edwards R, Smith L, Sempowski G, Eaton A, Muramatsu H, Henderson R, Tam Y, Barbosa C, Tang J, Cain D, Santra S, Moore I, Andersen H, Lewis M, Golding H, Seder R, Khurana S, Montefiori D, Pardi N, Weissman D, Baric R, Acharya P, Haynes B, Saunders K. Nonstabilized SARS-CoV-2 spike mRNA vaccination induces broadly neutralizing antibodies in nonhuman primates. Science Translational Medicine 2025, 17: eadn5651. PMID: 40498855, DOI: 10.1126/scitranslmed.adn5651.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsB-cell lineageMessenger RNA vaccineReceptor-binding domainSARS-CoV-2Neutralizing antibodiesMessenger RNASARS-CoV-2 spike mRNA vaccineSARS-CoV-2 challengeImmunization of macaquesVaccine-induced antibodiesAncestral spike proteinSpike proteinEmergence of severe acute respiratory syndrome coronavirus 2Human nAbsViral vectorsSevere acute respiratory syndrome coronavirus 2Acute respiratory syndrome coronavirus 2MRNA vaccinesRespiratory syndrome coronavirus 2Protective immunitySyndrome coronavirus 2NAbsCOVID-19 vaccineOmicron VOCIn vitroHow dengue defies dogma: An extrafollicular tale.
Polster J, Martinez D. How dengue defies dogma: An extrafollicular tale. Science Immunology 2025, 10: eady4137. PMID: 40315296, DOI: 10.1126/sciimmunol.ady4137.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and Concepts
2024
Challenges for developing broad-based mucosal vaccines for respiratory viruses
Seo J, Polster J, Israelow B, Corbett-Helaire K, Martinez D. Challenges for developing broad-based mucosal vaccines for respiratory viruses. Nature Biotechnology 2024, 42: 1765-1767. PMID: 39643701, DOI: 10.1038/s41587-024-02486-8.Peer-Reviewed Original ResearchCitationsAltmetricPre-vax metabolic clues: Cracking the code to a better dengue vaccine.
Akther F, Martinez D. Pre-vax metabolic clues: Cracking the code to a better dengue vaccine. Science Immunology 2024, 9: eads7640. PMID: 39241056, DOI: 10.1126/sciimmunol.ads7640.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsThe oral nucleoside prodrug GS-5245 is efficacious against SARS-CoV-2 and other endemic, epidemic, and enzootic coronaviruses
Martinez D, Moreira F, Catanzaro N, Diefenbacher M, Zweigart M, Gully K, De la Cruz G, Brown A, Adams L, Yount B, Baric T, Mallory M, Conrad H, May S, Dong S, Scobey D, Nguyen C, Montgomery S, Perry J, Babusis D, Barrett K, Nguyen A, Nguyen A, Kalla R, Bannister R, Feng J, Cihlar T, Baric R, Mackman R, Bilello J, Schäfer A, Sheahan T. The oral nucleoside prodrug GS-5245 is efficacious against SARS-CoV-2 and other endemic, epidemic, and enzootic coronaviruses. Science Translational Medicine 2024, 16: eadj4504. PMID: 38776389, PMCID: PMC11333937, DOI: 10.1126/scitranslmed.adj4504.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsSARS-CoV-2Clinical evaluationMouse modelRNA-dependent RNA polymeraseVaccine-elicited immunityPersistent emergenceAcute lung injuryDose-dependent reductionSARS-CoVBody weight lossSevere COVID-19Parent nucleoside GS-441524Outcomes in vivoEmergence of severe acute respiratory syndrome coronavirus 2MERS-CoVRNA polymeraseOral prodrugAntiviral activitySARS-CoV-2 VOCsLung injuryGlobal health concernSevere acute respiratory syndrome coronavirus 2Acute respiratory syndrome coronavirus 2Pulmonary functionTreatment strategiesmRNA-LNP vaccine-induced CD8+ T cells protect mice from lethal SARS-CoV-2 infection in the absence of specific antibodies
Montoya B, Melo-Silva C, Tang L, Kafle S, Lidskiy P, Bajusz C, Vadovics M, Muramatsu H, Abraham E, Lipinszki Z, Chatterjee D, Scher G, Benitez J, Sung M, Tam Y, Catanzaro N, Schäfer A, Andino R, Baric R, Martinez D, Pardi N, Sigal L. mRNA-LNP vaccine-induced CD8+ T cells protect mice from lethal SARS-CoV-2 infection in the absence of specific antibodies. Molecular Therapy 2024, 32: 1790-1804. PMID: 38605519, PMCID: PMC11184341, DOI: 10.1016/j.ymthe.2024.04.019.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsCD8+ T cellsLethal SARS-CoV-2 infectionT cellsSARS-CoV-2 infectionMRNA-LNPVaccine-induced CD8+ T cellsCD8+ T-cell depletionSARS-CoV-2Protective antibodiesCD8+ T cellsT-cell depletionSpike-specific antibodiesMRNA-LNP vaccinesWeight lossIntrinsic resistanceVaccine-induced protectionSARS-CoV-2 spikeLethal COVID-19Mutated epitopesC57BL/6 miceSARS-CoV-2 variantsCD8+SARS-CoV-2 pathogenesisCell depletionMice
Academic Achievements & Community Involvement
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Honors
honor Early Career Researcher Award
07/01/2024National AwardElsevier VaccineDetailsPortugalhonor AAI Aspire Award
01/18/2024National AwardAmerican Association of ImmunologistsDetailsUnited Stateshonor Rising Stars Mentorship Program Awardee
11/01/2022National AwardGlobal Virus NetworkDetailsUnited Stateshonor Dr. Eddie Mendez Award
06/09/2022National AwardFred Hutchinson Cancer CenterDetailsUnited Stateshonor Hanna H. Gray Fellowship
12/18/2020National AwardHoward Hughes Medical InstituteDetailsUnited States
News
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News
- November 12, 2025
Twenty-Seven YSM Faculty Members Recognized for Highly Cited Research
- February 04, 2025
Yale University Joins Global Virus Network as Center of Excellence
- October 25, 2023
Could a New Vaccine Head Off the Next Pandemic?
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300 George Street
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New Haven, CT 06511
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Yale Only Dr. Angie Rasmussen
Yale Only Akiko Iwasaki, PhD - Noah Wolcott Palm, PhD - Emilia Favuzzi, PhD - Shawn Ferguson, PhD - Le Zhang, PhD - David R. Martinez, PhD - Yifei Cai