Cyprien Rivier, MD, MSc
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Research
Publications
2025
Differential results of genetic risk scoring for multiple sclerosis in European and African American populations
Rivier C, Xu L, Clocchiatti-Tuozzo S, Zhao H, Ohno-Machado L, Hafler D, Falcone G, Longbrake E. Differential results of genetic risk scoring for multiple sclerosis in European and African American populations. Multiple Sclerosis Journal 2025, 31: 1304-1313. PMID: 40991630, DOI: 10.1177/13524585251377607.Peer-Reviewed Original ResearchConceptsGenetic risk scoreInternational ClassificationSystematized Nomenclature of MedicineAfrican ancestryRisk scoreCross-sectional studyHigh-risk individualsMultiple sclerosisSystematized NomenclatureAfrican American populationAfrican ancestry groupMS prevalenceAncestry groupsMS riskNomenclature of MedicineAmerican populationParticipantsAfrican participantsAncestryEuropean populationsClinical trialsDifferentiation resultsScoresIndividualsPopulationCharacterizing Stroke Clots Using Single‐Cell Sequencing
Renedo D, Barak T, DeLong J, Acosta J, Sujijantarat N, Koo A, Rivier C, Clocchiatti-Tuozzo S, Huo S, Antonios J, Giles J, Falcone G, Sheth K, Hebert R, Gunel M, Sansing L, Navaratnam D, Matouk C. Characterizing Stroke Clots Using Single‐Cell Sequencing. Journal Of The American Heart Association 2025, 14: ejaha/2025/041738-t. PMID: 40878981, PMCID: PMC12553457, DOI: 10.1161/jaha.125.041738.Peer-Reviewed Original ResearchConceptsMulti-marker analysisGene expressionMulti-marker Analysis of GenoMic AnnotationCell type-specific gene expressionT cellsGenome-wide association studiesGene expression of cellsSingle-cell RNA sequencingPotential biomarkersTIMP1Genes associated with atherosclerosisHLA-DRB1*01Single-cell sequencingExpression of genesUpregulated expression of genesGene expression profilesCarotid atherosclerosisGenome annotationCD8 T cellsUpregulated expressionImmune cell compositionAssociation studiesNatural killer cellsImmune cell populationsLarge vessel occlusion strokePolygenic Resistance to Blood Pressure Treatment and Stroke Risk: Insights from the All of Us Research Program
Huo S, Rivier C, Clocchiatti‐Tuozzo S, Renedo D, Petersen N, de Havenon A, Meeker D, Zhao H, Ohno‐Machado L, Sheth K, Falcone G. Polygenic Resistance to Blood Pressure Treatment and Stroke Risk: Insights from the All of Us Research Program. Annals Of Neurology 2025 PMID: 40827941, DOI: 10.1002/ana.78009.Peer-Reviewed Original ResearchUs Research ProgramUncontrolled hypertensionSystolic BPGenetic riskSusceptibility to hypertensionRates of uncontrolled hypertensionPolygenic risk scoresAssociated with higher systolic BPOdds of uncontrolled hypertensionCox proportional hazards regressionUnited Kingdom BiobankGenetic association studiesHigh-risk individualsHigher systolic BPProportional hazards regressionBlood pressure treatmentIncident strokeStroke hazardBlood pressureHigher RatesSystolic blood pressureHypertensive adultsDiagnosed hypertensionBP medicationsHazards regressionAssociation of Polygenic Susceptibility to Hyperlipidemia With Cholesterol Control and Recurrent Stroke in Ischemic Stroke Survivors
Wu K, Huo S, Rivier C, Torres-Lopez V, Sharma R, de Havenon A, Worrall B, Sheth K, Falcone G. Association of Polygenic Susceptibility to Hyperlipidemia With Cholesterol Control and Recurrent Stroke in Ischemic Stroke Survivors. Neurology 2025, 105: e213966. PMID: 40825160, DOI: 10.1212/wnl.0000000000213966.Peer-Reviewed Original ResearchConceptsIschemic stroke survivorsStroke survivorsAssociated with riskSusceptible to hyperlipidemiaHigh riskUK BiobankResistant hyperlipidemiaCholesterol controlUncontrolled hyperlipidemiaSurvivors of ischemic strokeHigher risk of recurrent vascular eventsPolygenic risk scoresRisk factor controlRisk of recurrent vascular eventsAdverse genetic profileLow-density lipoprotein cholesterolRisk of acute coronary eventsGenetic association studiesRecurrent strokeClinical trajectoryGenetic risk variantsRisk of recurrent strokeAcute ischemic stroke survivorsPolygenic profilePrecision medicine toolsGlobal gender representation in neurointerventional surgery: a natural language processing analysis of journal publications
Renedo D, Koo A, Amllay A, Sujijantarat N, Fathima B, Haynes J, Falcone G, Sheth K, Fadel S, Johnson M, Hebert R, Rivier C, Matouk C. Global gender representation in neurointerventional surgery: a natural language processing analysis of journal publications. Journal Of NeuroInterventional Surgery 2025, jnis-2025-023956. PMID: 40813072, DOI: 10.1136/jnis-2025-023956.Peer-Reviewed Original ResearchNatural language processingNatural language processing methodsExtract metadataNatural language processing analysisLanguage processingArtificial intelligenceFemale last authorshipAcademic publishingAuthorship ratesFemale first authorshipAuthor affiliationJournal publicationsInstitutional affiliationFirst authorshipRepresentationSurgery journalsAPIAuthorshipProcess analysisMetadataFemale authorshipJournalsIntelligenceE-090 Acute ischemic stroke risk following cardiac interventions in the United States from 2016 to 2021
Koo A, Zhou L, Hameed I, Rivier C, Clocchiatti-Tuozzo S, Kamel H, Falcone G, Ney J, Sharma R, Matouk C, Yaghi S, Sheth K, de Havenon A. E-090 Acute ischemic stroke risk following cardiac interventions in the United States from 2016 to 2021. 2025, a153-a155. DOI: 10.1136/jnis-2025-snis.206.Peer-Reviewed Original ResearchO-056 SLAMF1 and non-traumatic subarachnoid hemorrhage: a multi-omics investigation of risk
Renedo D, Koo A, Sujijantarat N, Clocchiatti-Tuozzo S, Huo S, Acosta J, Hebert R, Gunel M, Sansing L, Sheth K, Falcone G, Rivier C, Matouk C. O-056 SLAMF1 and non-traumatic subarachnoid hemorrhage: a multi-omics investigation of risk. 2025, a48.2-a49. DOI: 10.1136/jnis-2025-snis.56.Peer-Reviewed Original ResearchAPOE ε4 and Risk of Intracranial Hemorrhage in Patients With Atrial Fibrillation Taking Apixaban
Clocchiatti-Tuozzo S, Rivier C, Renedo D, Huo S, de Havenon A, Hawkes M, Gilmore E, Schwamm L, Sheth K, Gill T, Falcone G. APOE ε4 and Risk of Intracranial Hemorrhage in Patients With Atrial Fibrillation Taking Apixaban. JAMA Neurology 2025, 82: 808-816. PMID: 40549373, PMCID: PMC12186128, DOI: 10.1001/jamaneurol.2025.0182.Peer-Reviewed Original ResearchRisk of intracranial hemorrhagePopulation-based studyYears of follow-up dataApo E4Cox proportional hazards modelsAPOE e4 alleleIntracranial hemorrhageRisk prediction scoreCerebral amyloid angiopathyClinical decision-makingProportional hazards modelAtrial fibrillationIncreased risk of ICHMultivariate Cox proportional hazards modelMain OutcomesIncident intracranial hemorrhageEuropean ancestryCohort studyInclusion criteriaHistory of ischemic strokeAmyloid angiopathyE4 variantHazards modelIncreased riskE4 alleleAcute Ischemic Stroke Risk Following Cardiac Interventions in the United States From 2016 to 2021
Koo A, Zhou L, Hameed I, Rivier C, Clocchiatti-Tuozzo S, Kamel H, Falcone G, Ney J, Sharma R, Matouk C, Yaghi S, Sheth K, de Havenon A. Acute Ischemic Stroke Risk Following Cardiac Interventions in the United States From 2016 to 2021. Neurology 2025, 105: e213766. PMID: 40493873, PMCID: PMC12165311, DOI: 10.1212/wnl.0000000000213766.Peer-Reviewed Original ResearchConceptsIntervention hospitalsSurvey weightsNon-Hispanic black ethnicityNIH Stroke ScaleStroke riskIschemic strokeFactors associated with ischemic strokeAssociated with female sexCardiac interventionsIschemic stroke riskIncidence of ischemic strokeVariables associated with riskRate of ischemic strokeNational Inpatient SampleHigh-risk populationDiagnosis-related groupsIntervention patientsCross-sectional cohortUnited StatesAcute ischemic stroke riskIn-Hospital DeathRisk of strokeSecondary analysisBlack ethnicityInpatient mortalityThe Brain Care Score and its associations with cardiovascular disease and cancer
Senff J, Rivier C, Tack R, Tan B, Kimball T, Brouwers H, Newhouse A, Fricchione G, Tanzi R, Yechoor N, Chemali Z, Anderson C, Rosand J, Falcone G, Singh S. The Brain Care Score and its associations with cardiovascular disease and cancer. Family Practice 2025, 42: cmaf034. PMID: 40464807, DOI: 10.1093/fampra/cmaf034.Peer-Reviewed Original ResearchConceptsLate-life depressionIncidence of cardiovascular diseaseCare scoresCardiovascular diseaseUK Biobank (UKBCases of cardiovascular diseaseRisk of dementiaHealth-related behaviorsIncident cardiovascular diseaseModifiable risk factorsCases of cancerCancer typesUKB participantsCox proportional hazards regression analysisProportional hazards regression analysisHazards regression analysisHealthy agingRisk factorsUKBDementiaRegression analysisFollow-upParticipantsAge-related brain diseasesBaseline
News
News
- June 24, 2025
Announcing the Center for Brain & Mind Health 2025 Pilot Grant Program Awardees
- November 20, 2024
Brain Bleeds: How Biological Sex Affects Severity and Outcomes
- July 15, 2024
Rivier Receives Ralph L. Sacco Scholarship for Brain Health
- July 05, 2023
Cyprien Rivier, MD, MSc Wins ESOC Young Research Investigator Award in Stroke
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