2024
1507-P: Mixed-Meal Tolerance Test (MMTT) C-Peptide and BETA-2 Score Predict Underlying ß-Cell Secretory Capacity following Islet Transplantation for Type 1 Diabetes (T1D)
FLATT A, MATUS A, GALLOP R, MARKMANN E, DALTON-BAKES C, PELECKIS A, LIU C, NAJI A, RICKELS M. 1507-P: Mixed-Meal Tolerance Test (MMTT) C-Peptide and BETA-2 Score Predict Underlying ß-Cell Secretory Capacity following Islet Transplantation for Type 1 Diabetes (T1D). Diabetes 2024, 73 DOI: 10.2337/db24-1507-p.Peer-Reviewed Original ResearchMixed-meal tolerance testB-cell secretory capacityGlucose-potentiated arginineC-peptideBeta 2Secretory capacityBETA-2 scoreRepeated-measures correlation analysisYears post-transplantB cell functionIslet transplantationModerate effect sizeAllogeneic islet transplantationC-peptide/glucose ratioType 1 diabetesIslet graft functionGraft functionPost-transplantGraft monitoringTolerance testC-peptide/glucoseTransplantationLongitudinal cohortEffect sizeSS cells
2023
Immunotherapy targeting B cells and long-lived plasma cells effectively eliminates pre-existing donor-specific allo-antibodies
Zhang Z, Markmann C, Yu M, Agarwal D, Rostami S, Wang W, Liu C, Zhao H, Ochoa T, Parvathaneni K, Xu X, Li E, Gonzalez V, Khadka R, Hoffmann J, Knox J, Scholler J, Marcellus B, Allman D, Fraietta J, Samelson-Jones B, Milone M, Monos D, Garfall A, Naji A, Bhoj V. Immunotherapy targeting B cells and long-lived plasma cells effectively eliminates pre-existing donor-specific allo-antibodies. Cell Reports Medicine 2023, 4: 101336. PMID: 38118406, PMCID: PMC10772570, DOI: 10.1016/j.xcrm.2023.101336.Peer-Reviewed Original ResearchConceptsChimeric antigen receptorLong-lived plasma cellsB-cell maturation antigenAllo-antibodiesMultiple myelomaB cellsChimeric antigen receptor-T therapyEfficacy of chimeric antigen receptorAllo-transplantationAnti-human leukocyte antigenTarget B cellsMemory B cellsCART-19T therapyMaturation antigenLeukocyte antigenAntigen receptorClinical efficacyMurine modelPlasma cellsClinical evaluationHyperacute rejectionDesensitization approachImmunotherapyTransplantation