2016
Post-Translational Modifications in sperm Proteome: The Chemistry of Proteome diversifications in the Pathophysiology of male factor infertility
Samanta L, Swain N, Ayaz A, Venugopal V, Agarwal A. Post-Translational Modifications in sperm Proteome: The Chemistry of Proteome diversifications in the Pathophysiology of male factor infertility. Biochimica Et Biophysica Acta 2016, 1860: 1450-1465. PMID: 27062907, DOI: 10.1016/j.bbagen.2016.04.001.Peer-Reviewed Original ResearchConceptsPost-translational modificationsSperm proteinsSperm functionOccurrence of post-translational modificationsExpressed protein complementHuman sperm proteinsProtein synthesis machineryAnalysis of post-translational modificationsComplex interaction networksProteome diversificationSperm proteomeFemale reproductive tractHuman spermatozoaProtein complementStructure-function relationshipsSynthesis machineryInteraction networkProtein stabilityMale infertilitySpermMale factor infertilitySpermatozoaProtein profilesDifferential occurrenceFertility potential
2014
Infertile men older than 40 years are at higher risk of sperm DNA damage
Alshahrani S, Agarwal A, Assidi M, Abuzenadah A, Durairajanayagam D, Ayaz A, Sharma R, Sabanegh E. Infertile men older than 40 years are at higher risk of sperm DNA damage. Reproductive Biology And Endocrinology 2014, 12: 103. PMID: 25410314, PMCID: PMC4258051, DOI: 10.1186/1477-7827-12-103.Peer-Reviewed Original ResearchConceptsSperm DNA damageRisk of sperm DNA damageInfertile menReactive oxygen speciesDNA damagePercentage of sperm DNA fragmentationLevels of sperm DNA damageSemen analysisSeminal reactive oxygen speciesPaternal ageSperm DNA fragmentationAge groupsAssociated with higher riskPaternal age >DNA fragmentationSperm parametersAdvanced paternal ageSemen parametersSemen qualityEffect of paternal ageSpermRetrospective studyGroup BMethodsA totalGroup A