2024
The homeodomain transcription factor Six3 regulates hypothalamic Pomc expression and its absence from POMC neurons induces hyperphagia and mild obesity in male mice
Yu H, Chiang A, Rubinstein M, Low M. The homeodomain transcription factor Six3 regulates hypothalamic Pomc expression and its absence from POMC neurons induces hyperphagia and mild obesity in male mice. Molecular Metabolism 2024, 87: 101993. PMID: 39025297, PMCID: PMC11327434, DOI: 10.1016/j.molmet.2024.101993.Peer-Reviewed Original ResearchHypothalamic POMC expressionPOMC neuronsPOMC expressionFood intakeMild obesityDaily food intakeFemale micePOMC immunoreactivityAdult micePOMC-expressing neuronsSuppress food intakeMaintenance of physiological levelsPOMC mRNA levelsReduced POMC expressionBody weightKnockout mouse modelMouse hypothalamic neuronsIncreased daily food intakeCentral melanocortinEnhanced energy expenditureExpression of Six3Functional significanceMelanocortin neuronsHypothalamic neuronsAnorexigenic neuropeptides
2016
Hypothalamic Pomc ‐deficiency Impairs the Function of Leptin to Decrease Food Intake and Bodyweight
Chhabra K, Adams J, Jones G, Rubinstein M, Low M. Hypothalamic Pomc ‐deficiency Impairs the Function of Leptin to Decrease Food Intake and Bodyweight. The FASEB Journal 2016, 30 DOI: 10.1096/fasebj.30.1_supplement.1293.4.Peer-Reviewed Original ResearchFunction of leptinHistory of obesityNormal body weightPlasma leptin levelsKO miceFood intakeHypothalamic POMCBody weightLeptin levelsLeptin administrationLeptin sensitivityHigher plasma leptin levelsLeptin receptor gene expressionIntracerebroventricular leptin administrationMagnitude of obesityPomc knockout miceReversal of obesityWeight-matched miceDiabetes Research CenterNormal energy homeostasisWeight-matched groupsLongitudinal studyReceptor gene expressionARC POMCPrevents obesity