Stacy Malaker

2026

• O‑Glycosylation Shapes the Proteolytic Landscape of the Native Tear Peptidome

  Chang V, Chen R, Lian I, Mahoney K, Malaker S. O‑Glycosylation Shapes the Proteolytic Landscape of the Native Tear Peptidome. JACS Au 2026 DOI: 10.1021/jacsau.6c00834.

  Peer-Reviewed Original Research

  Concepts

• Mapping galectin-3 ligands in human tear fluid establishes spliceoform-dependent lacritin binding

  Chang V, Lian I, Mahoney K, Romano J, Afshari A, Chen R, Chen X, Fineide F, Khan A, Utheim T, Karlsson N, Laurie G, Malaker S. Mapping galectin-3 ligands in human tear fluid establishes spliceoform-dependent lacritin binding. Communications Biology 2026 PMID: 42191868, DOI: 10.1038/s42003-026-10337-2.

  Peer-Reviewed Original Research

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• Glycosite mapping and in situ mass spectrometry imaging of MUC2 glycopeptides via on-slide mucinase digestion

  Lowery S, Ribi M, Chongsaritsinsuk J, Tran I, Grimsley G, Stubler R, Mahoney K, Lucas T, Charkoftaki G, Santos-Neto A, Varki N, Vasiliou V, Angelo M, Drake R, Malaker S. Glycosite mapping and in situ mass spectrometry imaging of MUC2 glycopeptides via on-slide mucinase digestion. Nature Communications 2026 PMID: 42098121, DOI: 10.1038/s41467-026-72853-3.

  Peer-Reviewed Original Research

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• 452 Region-specific proteomic analysis of aging rhesus macaques following chronic glutamate-carboxypeptidase-II (GCPII) inhibition elucidates potential treatment strategies for sporadic Alzheimer’s disease

  Datta D, Steigmeyer A, Battison A, Liebman I, van Dyck C, Slusher B, Arnsten A, Malaker S, Datta D. 452 Region-specific proteomic analysis of aging rhesus macaques following chronic glutamate-carboxypeptidase-II (GCPII) inhibition elucidates potential treatment strategies for sporadic Alzheimer’s disease. Journal Of Clinical And Translational Science 2026, 10: 143-144. PMCID: PMC13173198, DOI: 10.1017/cts.2026.10595.

  Peer-Reviewed Original Research

  Concepts

• Screening of the transcriptome, mucinome, and O‐/N‐glycans of the intestinal goblet cell model HT29‐MTX during zinc deficiency

  Schüßler C, Chung N, Leonard R, Sprenger H, Braeuning A, Morelle W, Foulquier F, Malaker S, Masselot C, Maares M. Screening of the transcriptome, mucinome, and O‐/N‐glycans of the intestinal goblet cell model HT29‐MTX during zinc deficiency. Lebensmittelchemie 2026, 80: s1-113-s1-113. DOI: 10.1002/lemi.202651077.

  Peer-Reviewed Original Research

  Concepts

• Impaired glycosylation promotes rapid transition to hepatocellular carcinoma in model of diet induced steatotic liver disease

  Singh A, Chaube B, Citrin K, Fowler J, Lee S, Catarino J, Knight J, Lowery S, Shree S, Mahoney K, Boutagy N, Ruz-Maldonado I, Harry K, Shanabrough M, Ross T, Malaker S, Suárez Y, Fernández-Hernando C, Grabińska K, Sessa W. Impaired glycosylation promotes rapid transition to hepatocellular carcinoma in model of diet induced steatotic liver disease. Journal Of Clinical Investigation 2026, 136: e197719. PMID: 41805633, PMCID: PMC13132402, DOI: 10.1172/jci197719.

  Peer-Reviewed Original Research

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• Xylosyltransferase engineering to manipulate proteoglycans in mammalian cells

  Li Z, Chawla H, Di Vagno L, Ní Cheallaigh A, Critcher M, Sammon D, Gonzalez-Rodriguez E, Briggs D, Chung N, Chang V, Mahoney K, Cioce A, Bineva-Todd G, Wang P, Liu Y, Murphy L, Chen Y, Narimatsu Y, Miller R, Willems L, Malaker S, Huang M, Miller G, Hohenester E, Schumann B. Xylosyltransferase engineering to manipulate proteoglycans in mammalian cells. Nature Chemical Biology 2026, 22: 612-621. PMID: 41559400, PMCID: PMC13038410, DOI: 10.1038/s41589-025-02113-w.

  Peer-Reviewed Original Research

  Citations

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• Erratum: Decoding Extracellular Protein Glycosylation in Human Health and Disease

  Steigmeyer A, Lowery S, Rangel-Angarita V, Malaker S. Erratum: Decoding Extracellular Protein Glycosylation in Human Health and Disease. Annual Review Of Analytical Chemistry 2026 DOI: 10.1146/annurev-ac-18-010726-200001.

  Commentaries, Editorials and Letters

• Enrichment strategies for mucin-domain O-glycoproteins

  Finn S, Malaker S. Enrichment strategies for mucin-domain O-glycoproteins. Methods In Enzymology 2026 DOI: 10.1016/bs.mie.2026.03.003.

  Peer-Reviewed Original Research

  Concepts

• Characterization of O-glycoproteases for applications in mass spectrometry

  Steigmeyer A, Chongsaritsinsuk J, Malaker S. Characterization of O-glycoproteases for applications in mass spectrometry. Methods In Enzymology 2026 DOI: 10.1016/bs.mie.2026.03.004.

  Peer-Reviewed Original Research

  Concepts