Sayed (Ausim) Azizi, MD, PhD, FANA
he/him/his
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About
Research
Publications
2023
A role for the prefrontal cortex in reward, punishment, and animal behavior: an anatomical/functional framework
Azizi S. A role for the prefrontal cortex in reward, punishment, and animal behavior: an anatomical/functional framework. Neuroscience Letters 2023, 808: 137296. DOI: 10.1016/j.neulet.2023.137296.Peer-Reviewed Original ResearchLateral prefrontal cortexPrefrontal cortexMotor association areasExecution of movementsOrbitofrontal cortexMotor informationAdaptive behaviorAssociation areasBrain's abilityIntegration hubCortexBrain statesMPFCConscious selfControl behaviorAnimal behaviorMemoryMedial partBrainImpulseOPFCMonoamineBehaviorRewardMotor
2022
Interdisciplinary patient-centred poststroke care in Follow-up After Stroke, Screening and Treatment (FASST) clinic model: a proof-of-concept pilot study
Kim M, Cleymaet S, Kim S, Andres J, Ruchalski C, Kim Y, Azizi S, Sharrief A, Naqvi I. Interdisciplinary patient-centred poststroke care in Follow-up After Stroke, Screening and Treatment (FASST) clinic model: a proof-of-concept pilot study. Integrated Healthcare Journal 2022, 4: e000118. PMID: 37440858, PMCID: PMC10327447, DOI: 10.1136/ihj-2021-000118.Peer-Reviewed Original ResearchRisk factor controlImprove risk factor controlFactor controlPoststroke careInterdisciplinary clinicPoststroke complicationsSecondary stroke preventionPost-stroke careImprove health outcomesHealth-related behaviorsPilot studyPost-stroke complicationsQuality of lifeStroke preventionPharmacist collaborationHealth outcomesFollow-upSocial supportClinical modelStroke physiciansMedication changesFunctional statusOutpatient modelMedication adjustmentsOutcome scores
2021
Role of the cerebellum in the phenotype of neurodegenerative diseases: Mitigate or exacerbate?
Azizi S. Role of the cerebellum in the phenotype of neurodegenerative diseases: Mitigate or exacerbate? Neuroscience Letters 2021, 760: 136105. PMID: 34246702, DOI: 10.1016/j.neulet.2021.136105.Peer-Reviewed Original ResearchConceptsBehavioural component of emotionsFunctional connectivity dataComponents of emotionVisuospatial disordersFunctional connectivityBrain activityFMRI mapsBehavioral componentsCerebellar anatomyCerebellar vermisCerebellumConnectivity dataParkinson's patientsCerebral cortexCognitionIncreased activityBrainMotor-related inputsFMRIDegenerative diseasesSensory systemsCortexEmotionsNeuroscienceClinical symptoms
2020
Monoamines: Dopamine, Norepinephrine, and Serotonin, Beyond Modulation, “Switches” That Alter the State of Target Networks
Azizi S. Monoamines: Dopamine, Norepinephrine, and Serotonin, Beyond Modulation, “Switches” That Alter the State of Target Networks. The Neuroscientist 2020, 28: 121-143. PMID: 33292070, DOI: 10.1177/1073858420974336.Peer-Reviewed Original ResearchConceptsFunction of brain networksPathogenesis of neuropsychiatric diseasesFunction of monoaminesBrain target areasEffects of monoaminesPrefrontal areasBrain networksNeuropsychiatric diseasesBrain functionMonoamineMonoaminergic cellsBrain statesBrain operationsBrainBehavioral aspectsElectrophysiological effectsBrain stemTarget neuronsInformation processing circuitsNervous systemSerotoninDopamineEmotionsForebrainLibrary of informationNeurological injuries in COVID-19 patients: direct viral invasion or a bystander injury after infection of epithelial/endothelial cells
Azizi S, Azizi S. Neurological injuries in COVID-19 patients: direct viral invasion or a bystander injury after infection of epithelial/endothelial cells. Journal Of NeuroVirology 2020, 26: 631-641. PMID: 32876900, PMCID: PMC7465881, DOI: 10.1007/s13365-020-00903-7.Peer-Reviewed Original ResearchMeSH KeywordsAngiotensin-Converting Enzyme 2BetacoronavirusBrainBrain DiseasesBystander EffectCoronavirus InfectionsCOVID-19Epithelial CellsGene Expression RegulationHost-Pathogen InteractionsHumansLungNeuronsOlfaction DisordersPandemicsPeptidyl-Dipeptidase APneumonia, ViralPulmonary EmbolismSARS-CoV-2Signal TransductionSpike Glycoprotein, CoronavirusStrokeConceptsCOVID-19 patientsBystander injuryNeurological complicationsSARS-CoV-2Cerebral vascular endothelial cellsSecondary to hypoxiaInitial symptoms of COVID-19Post-COVID-19 patientsInflammatory neuromuscular diseasesVascular endothelial cellsImmunological abnormalitiesHost cellsSymptoms of COVID-19Oral cavityMetabolic abnormalitiesThrombo-embolismEpithelial/endothelial cellsInitial symptomsNeurological injuryEpithelial cellsFunctional receptorsPatientsPeripheral nervesMolecular mimicryEndothelial cells
2019
Design and Implementation of a Multidisciplinary Integrated Stroke Prevention Clinic (P3.3-001)
Kim S, Kim Y, Andres J, Hellerslia V, Azizi S, Sharrief A, Naqvi I. Design and Implementation of a Multidisciplinary Integrated Stroke Prevention Clinic (P3.3-001). Neurology 2019, 92 DOI: 10.1212/wnl.92.15_supplement.p3.3-001.Peer-Reviewed Original Research
2017
Synucleinopathies in neurodegenerative diseases: Accomplices, an inside job and selective vulnerability
Azizi S, Azizi S. Synucleinopathies in neurodegenerative diseases: Accomplices, an inside job and selective vulnerability. Neuroscience Letters 2017, 672: 150-152. PMID: 29217261, DOI: 10.1016/j.neulet.2017.12.003.Peer-Reviewed Original Research
2016
Milton Alter, MD, PhD (1929–2016)
Kelley R, Azizi S. Milton Alter, MD, PhD (1929–2016). Neurology 2016, 87: 976-977. DOI: 10.1212/wnl.0000000000003074.Peer-Reviewed Original ResearchCharacterizing absolute lymphocyte count profiles in dimethyl fumarate–treated patients with MS
Fox R, Chan A, Gold R, Phillips J, Selmaj K, Chang I, Novas M, Rana J, Marantz J, Ambler Z, Ehler E, Havrdova E, Meluzinova E, Rektor I, Talab R, Gold R, Hartung H, Csanyi A, Csiba L, Jakab G, Hintzen R, Polman C, Drozdowski W, Fryze W, Kochanowicz J, Kwiecinski H, Maciejek Z, Schimrigk S, Selmaj K, Szczudlik A, Wajgt A, Belova A, Boiko A, Elchaninov A, Kozlov V, Odinak M, Shvarkov S, Skoromets A, Stolyarov I, Vorobieva O, Zavalishin I, Hillert J, Olsson T, Kappos L, Eraksoy M, Karabudak R, Siva A, Giovannoni G, Hawkins C, Sharief M, Sharrack B, Confavreux C, Ware J, Barnett M, Paine M, Lechner-Scott J, Beran R, Chapman C, Schwartz R, Butzkueven H, Casse R, Macdonell R, Berger T, Fazekas F, Ransmayr G, Vass K, Belachew S, De Deyn P, Decoo D, Dubois B, Medaer R, Seeldrayers P, Sindic C, Gaer L, Vanopdenbosch L, Grgic S, Bar-Or A, Bhan V, Bouchard J, Christie S, Grammond P, Jacques F, Veloso F, Vorobeychik G, Brinar V, Demarin V, Rudež J, Soldo-Butković S, Vurdelja R, Ambler Z, Doležil D, Havrdova E, Kanovsky P, Meluzinova E, Nova'k J, Rektor I, Skoda O, Duchcovská M, Camu W, Antoanela P, Coman I, Confavreux C, Edan G, Gout O, Lebrun-Frenay C, Papeix A, Vermersch P, Bachus-Banaschak K, Berghoff M, Bethke F, Boldt H, Chan A, Diener H, Eisensehr I, Emrich P, Griewing B, Haas J, Heesen C, Hoffmann F, Hufnagel A, Heidenreich F, Kleiter I, Lüer W, Marckmann-Böenke S, Marziniak M, Stangel M, Oschmann P, Rosenkranz T, Schneider H, Siefjediers V, Springub J, Stangel M, Stögbauer F, Bergh F, Tiel-Wilck K, Tinschert K, Grigoriadis N, Karageorgiou C, Kyritsis A, Papadimitriou A, Thomaides T, Vlaikidis N, Salguero Gonzalez L, Chon D, Ordoñez Sarg H, Agrawal C, Behari M, Cu V, Dwivedee S, Kothari S, Kulkarni R, Kushwaha S, Meena A, Mehndiratta M, Chandra Mukherjee S, Pandit L, Shah A, Shukla R, Vijayan K, Achiron A, Flechter S, Milo R, Vaknin-Dembinsky A, Pozzilli C, Daskalovska V, Castro Farfan F, Rangel Guerra R, Leyva I, Oropeza de Alba J, Revilla R, Rivera J, Gavriliuc M, Groppa S, Odainic O, Sanders E, Hupperts R, Mason D, Timmings P, Willoughby E, Czlonkowska A, Dorobek M, Drozdowski W, Fryze W, Hertmanowska H, Kleczkowska M, Kochanowicz J, Kwieciński H, Nowacki P, Podemski R, Potemkowski A, Selmaj K, Stelmasiak Z, Wajgt A, Zielinski T, Daskalovska V, Bajenaru A, Muresanu F, Nica S, Simu M, Drakulić S, Nadj C, Obradovic D, Vojinovic S, Turčáni P, Kahancová E, Kurca E, Lisý L, Krajnak V, Badenhorst F, Green J, Heckmann J, Isaacs M, Kappos L, Linnebank M, Müller S, Buchakchyys'ka N, Goloborodko A, Kobys T, Lebedynets V, Lytvynenko N, Nehrych T, Pasyura I, Ryabichenko T, Voloshina N, Duddy M, Hawkins C, Nicholas R, Palace J, Sharrack B, Silber E, Turner B, Camac A, Chumley W, Crayton H, Dixit S, Edwards K, English J, Freedman S, Gordon N, Gazda S, Goldstick L, Gottschalk P, Grazioli E, Grainger W, Green B, Grelinger B, Gudesblatt M, Gupta A, Hayat G, Hendin B, Henson L, Hentati A, Herrman C, Itkin A, Janus T, Kasper L, Lathi E, Mowry E, Parry G, Perel A, Rao T, Riskind P, Rizvi S, Rossman H, Scott T, Shafer S, Storey J, Thrower B, Rossen M, Tosches W, Trefts L, Turel A, Weinstock-Guttman B, Gold R, Kappos L, Arnold D, Bar-Or A, Giovannoni G, Selmaj K, Dawson K, Gallacher P, Milla C, Yang M, Antel J, Bakris G, Chung R, Kowey P, Polman C, Richert J, Seibert B, Ware J, Brandes D, Brassat D, Cohen B, Diem R, Goldman M, Herndon R, Miller A, Tumani H, Kneebone C, Fedulau A, Likhachev S, Mikhailova E, Naumova H, Decoo D, Sindic C, Gaer L, Grgic S, Sinanovic O, Suljic E, Deleva N, Georgiev D, Haralanov L, Ivanova S, Manchev I, Minchev D, Stamenova P, Tournev I, Vacheva E, Zahariev Z, Howell R, Vindas A, Bar-Or A, Blevins G, Kremenchutzky M, Veloso F, Witt N, Habek M, Rudež J, Soldo-Butković S, Vurdelja R, Doležil D, Havrdova E, Nova'k J, Vaclavik D, Antsov K, Gross-Paju K, Haldre S, Palu A, Toomsoo T, Al Khedr A, Camu W, De Seze J, Debouverie M, Defer G, Labauge P, Moreau T, Rumbach L, Angnstwurm K, Benes H, Berthele A, Boldt H, Christopher A, Derfuß T, Eisensehr I, Emrich P, Feneberg W, Hoffmann F, Hohlfeld R, Hüntemann R, Kallmann B, Kieseier B, Kleiter I, Landefeld H, Lüer W, Masri S, Mäurer M, Nelles G, Oschmann P, Paschen C, Reifschneider G, Sailer M, Schimrigk S, Spiegel-Meixensberger M, Steinbrecher A, Storch-Hagenlocher B, Tackenberg B, Tiel-Wilck K, Karageorgiou C, Papathanasopoulos P, Thomaides T, Vlaikidis N, Arjundas D, Behari M, Shah S, Ghosh A, Ghosh P, Ichaporia N, Khurana D, Kulkarni R, Mehndiratta M, Mehta N, Misra U, Mukherji J, Nellikunja S, Radhakrishnan S, Salem A, Sethi P, Singh G, Lines C, Singh M, Singh Y, Srinivasa R, Vijayan K, Hutchinson M, Sweeney B, Gilad R, Shahien R, Metra M, Paegle A, Daskalovska V, Delgado C, Escamilla J, Estañol B, Lopez N, Macias M, Punzo G, Quiñones S, Renteria M, Santos C, Gavriliuc M, Groppa S, Odainic O, Timmings P, Czlonkowska A, Dorobek M, Drozdowski W, Fryze W, Hertmanowska H, Kaminska A, Kapelusiak-Pielok M, Kleczkowska M, Kochanowicz J, Kwieciński H, Losy J, Nowacki P, Nyka W, Pierzchala K, Podemski R, Potemkowski A, Selmaj K, Stelmasiak Z, Szczudlik A, Tutaj A, Wajgt A, Zielinski T, Chinea A, Balasa R, Ionescu-Dimancea V, Mihancea P, Popescu C, Protosevici L, Drakulić S, Nadj C, Raicevic R, Vojinovic S, Kahancová E, Kurca E, Lisý L, Turčáni P, Arroyo R, Fernández O, Guijarro C, Izquierdo G, Montalbán X, Oreja-Guevara C, Prieto J, Lopez F, Buchakchyys'ka N, Chmyr G, Goloborodko A, Grytsay N, Kobys T, Kushnir G, Lebedynets V, Lytvynenko N, Moskovko S, Nehrych T, Palamar B, Pasyura I, Ryabichenko T, Voloshina N, Apperson M, Applebee A, Asher S, Ayala R, Ayres D, Azizi S, Baker M, Bauer B, Bomprezzi R, Buckler R, Carlini W, Cohan S, Crowell G, Edwards K, Eubank G, Felton W, Fodor P, Foley J, Ford C, Forester M, Fox E, Fox R, Freedman S, Garmany G, Gazda S, Giang D, Glaun B, Gold S, Gottesman M, Gudesblatt M, Herbert J, Herskowitz A, Honeycutt W, Huddlestone J, Hull R, Hunter S, Hutton G, Jacobs D, Janicki M, Khatri B, Kinkel R, Kita M, Krolczyk S, Krupp L, LaGanke C, Levin M, Licht J, Luzzio C, Lynch S, Mattson D, Mikol D, Miller T, Minagar A, Mitchell G, Moses H, Negroski D, Newman S, Pardo G, Patel M, Perel A, Phillips J, Picone M, Rammohan K, Rao T, Rinker J, Sadiq S, Schaeffer J, Sheremata W, Shin R, Shubin R, Silverman S, Smith R, Stein L, Stein M, Steiner D, Steingo B, Sullivan H, Sunter W, Vaishnav A, Vasquez A, Voci J, Warach J, Weinstock-Guttman B, Williams M, Wray S, Fox R, Phillips J, Hutchinson M, Havrdova E, Kita M, Wilson K, Yang M, Dawson K, Antel J, Ware J, Polman C, Kowey P, Chung R, Bakris G, Richert J, Seibert B, Brandes D, Brassat D, Cohen B, Diem R, Goldman M, Herndon R, Miller A, Tumani H, Alfaro-Vidal T, Crespo C, Foster J, Hunter K, Garcia-Gomez A, MacManus D, Miller D, Santana V, Tozer D, Kingshott-Wheeler C, Yousry T. Characterizing absolute lymphocyte count profiles in dimethyl fumarate–treated patients with MS. Neurology Clinical Practice 2016, 6: 220-229. PMID: 27347439, PMCID: PMC4909524, DOI: 10.1212/cpj.0000000000000238.Peer-Reviewed Original ResearchDelayed-release dimethyl fumarateAbsolute lymphocyte countMultiple sclerosisLymphocyte countDelayed-release dimethyl fumarate treatmentDMF discontinuationMean absolute lymphocyte countsEarly identification of patientsRelapsing-remitting multiple sclerosisUS prescribing informationTreatment of patientsIdentification of patientsComplete blood countDisease-modifying therapiesWhite blood cellsLymphocyte monitoringProlonged lymphopeniaBlood countClinical trialsPrescribing informationPatientsExtension studyBlood cellsDimethyl fumarateNeuroprotective effectsIntracerebral hemorrhage with intraventricular extension and no hydrocephalus may not increase mortality or severe disability
Mahta A, Katz P, Kamel H, Azizi S. Intracerebral hemorrhage with intraventricular extension and no hydrocephalus may not increase mortality or severe disability. Journal Of Clinical Neuroscience 2016, 30: 56-59. PMID: 26972705, DOI: 10.1016/j.jocn.2015.11.028.Peer-Reviewed Original ResearchConceptsAbsence of hydrocephalusModified Rankin ScalePoor functional outcomeFunctional outcomesIntraventricular extensionIntracerebral hemorrhagePresence of intraventricular hematomaRetrospective consecutive cohort studyMultivariate logistic regression analysisAssociated with increased mortalityAssociated with poor functional outcomeIncreased mortalitySpontaneous intracerebral hemorrhageConsecutive cohort studyAssociated with mortalityLogistic regression analysisSevere disabilityIntraventricular hematomaHematoma volumeCohort studyRankin ScaleHydrocephalusInclusion criteriaMortalityHematoma
Clinical Care
Overview
Ausim Azizi, MD, PhD, is the clinical chief of neurodegenerative disorders and specializes in treating patients with cognitive and memory problems.
“More than 20 percent of the U.S. population is over age 65 and given that cognitive and memory disorders are more common in older adults, it’s an important public health issue,” Dr. Azizi says. “Memory and cognition are at the core of one’s personality and there is a stigma and fear attached to dementia. People worry about genetics and transmission, and patients worry about becoming a shell of themselves.”
Dr. Azizi says he focuses on family members and caregivers as well. “Dementia doesn’t just affect the patient. In fact, when a patient stops remembering things, they perhaps suffer the least,” he says. “So, it becomes more about working with family and caregivers to keep patients comfortable and independent and to support the care givers.”
The most rewarding part of his job, he says, is educating patients and families. “I enjoy teaching them about their conditions and how to maintain their independence and give them power to live with their disease and treat the disease as best as we can,” he says.
Dr. Azizi’s research is focused on taking the functional, social, and biological aspects of dementia and determining how to deliver the best quality care to patients, which will also help caregivers, families, and the community.
Clinical Specialties
Neurology; Memory Disorders & Cognitive Neurology
Fact Sheets
Alzheimer's Disease
Learn More on Yale MedicineDementia
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Board Certifications
Neurology
- Certification Organization
- United Council for Neurologic Subspecialties
- Original Certification Date
- 2017
Neurocritical Care
- Certification Organization
- United Council for Neurologic Subspecialties
- Original Certification Date
- 2010
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333 Cedar Street
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