Noah Wolcott Palm, PhD
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Immunobiology
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Biography
Noah W. Palm is a Professor of Immunobiology at the Yale University School of Medicine. His laboratory focuses on illuminating the myriad interactions between the immune system and the gut microbiota in health and disease. Dr. Palm performed his doctoral work with Ruslan Medzhitov and his postdoctoral work with Richard Flavell, both at Yale University.
Last Updated on July 03, 2024.
Appointments
Immunobiology
ProfessorPrimary
Other Departments & Organizations
- Cancer Immunology
- Human and Translational Immunology Program
- Immunobiology
- Immunology
- Liver Center
- Microbiology
- Program for Neuroinflammation
- Yale Cancer Center
- Yale Center for Systems and Engineering Immunology (CSEI)
- Yale Combined Program in the Biological and Biomedical Sciences (BBS)
- Yale Fibrosis Program
Education & Training
- Postdoctoral Fellowship
- Yale University School of Medicine (2015)
- PhD
- Yale University, Immunobiology (2011)
- BA
- Macalester College, Biology (2004)
Research
Overview
Medical Research Interests
Adaptive Immunity; Allergy and Immunology; Brain-Gut Axis; Gastrointestinal Tract; Homeostasis; Inflammation; Microbiota; Neuroimmunomodulation
ORCID
0000-0001-7262-9455- View Lab Website
Palm Lab
Research at a Glance
Yale Co-Authors
Frequent collaborators of Noah Wolcott Palm's published research.
Publications Timeline
A big-picture view of Noah Wolcott Palm's research output by year.
Research Interests
Research topics Noah Wolcott Palm is interested in exploring.
Jason Crawford, PhD
Mytien Nguyen
Tyler Rice, PhD
Anjelica Martin, BS, RLATG
Andrew Wang, MD, PhD, AB
Deguang Song
19Publications
2,382Citations
Inflammation
Microbiota
Publications
Featured Publications
Highly multiplexed bioactivity screening reveals human and microbiota metabolome-GPCRome interactions
Chen H, Rosen C, González-Hernández J, Song D, Potempa J, Ring A, Palm N. Highly multiplexed bioactivity screening reveals human and microbiota metabolome-GPCRome interactions. Cell 2023, 186: 3095-3110.e19. PMID: 37321219, PMCID: PMC10330796, DOI: 10.1016/j.cell.2023.05.024.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsCommensal microbiota from patients with inflammatory bowel disease produce genotoxic metabolites
Cao Y, Oh J, Xue M, Huh WJ, Wang J, Gonzalez-Hernandez JA, Rice TA, Martin AL, Song D, Crawford JM, Herzon SB, Palm NW. Commensal microbiota from patients with inflammatory bowel disease produce genotoxic metabolites. Science 2022, 378: eabm3233. PMID: 36302024, PMCID: PMC9993714, DOI: 10.1126/science.abm3233.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsColorectal cancerInflammatory bowel disease patientsBowel disease patientsInflammatory bowel diseaseIndigenous gut microbesBowel diseaseDisease patientsCommensal microbiotaDNA damageColon tumorigenesisElicit DNA damageGut microbesGenotoxic metabolitesGut commensalsMorganella morganiiPatientsGenotoxic chemicalsDiseaseMicrobiotaMetabolitesGenotoxicityCancerMiceFull spectrumDamageWithin-host evolution of a gut pathobiont facilitates liver translocation
Yang Y, Nguyen M, Khetrapal V, Sonnert ND, Martin AL, Chen H, Kriegel MA, Palm NW. Within-host evolution of a gut pathobiont facilitates liver translocation. Nature 2022, 607: 563-570. PMID: 35831502, PMCID: PMC9308686, DOI: 10.1038/s41586-022-04949-x.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsHost evolutionGene expression programsCell wall structureNon-synonymous mutationsComparative genomicsIndependent lineagesExperimental evolutionExpression programsDivergent evolutionRegulatory genesBacterial behaviorCritical regulatorBacterial translocationGut commensalsTranslocationE. gallinarumMesenteric lymph nodesInitiation of inflammationImmune evasionWall structureEvade DetectionMucosal nicheLactobacillus reuteriCommensalGut microbiotaInterspecies commensal interactions have nonlinear impacts on host immunity
Rice TA, Bielecka AA, Nguyen MT, Rosen CE, Song D, Sonnert ND, Yang Y, Cao Y, Khetrapal V, Catanzaro JR, Martin AL, Rashed SA, Leopold SR, Hao L, Yu X, van Dijk D, Ring AM, Flavell RA, de Zoete MR, Palm NW. Interspecies commensal interactions have nonlinear impacts on host immunity. Cell Host & Microbe 2022, 30: 988-1002.e6. PMID: 35640610, PMCID: PMC9283318, DOI: 10.1016/j.chom.2022.05.004.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsImmunological outcomesCell activationIntestinal epithelial cell activationInflammatory bowel disease patientsBowel disease patientsDendritic cell activationMesenteric lymph nodesSystemic antibody responsesEpithelial cell activationImmunological milieuLymph nodesAntibody responseDisease patientsAkkermansia muciniphilaGnotobiotic miceHost immunityCommensal microbesHuman cohortsHuman gut bacteriaGut bacteriaMiceAllobaculumMuciniphilaDiseaseIncomplete penetranceAutoreactivity in naïve human fetal B cells is associated with commensal bacteria recognition
Chen JW, Rice TA, Bannock JM, Bielecka AA, Strauss JD, Catanzaro JR, Wang H, Menard LC, Anolik JH, Palm NW, Meffre E. Autoreactivity in naïve human fetal B cells is associated with commensal bacteria recognition. Science 2020, 369: 320-325. PMID: 32675374, DOI: 10.1126/science.aay9733.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsB cell toleranceB cellsCell toleranceEarly human fetal lifeHuman fetal B cellsPolyreactive B cellsHuman fetal lifeApoptotic cellsFetal B cellsHuman fetal liverB cell specificitySingle B cellsAbundant autoantibodiesGut microbiota assemblyNewborn seraFetal lifeBone marrowFetal developmentHealthy adultsCommensal bacteriaRepertoire breadthMicrobiota assemblyFetal liverPreimmune repertoireCell specificityA Forward Chemical Genetic Screen Reveals Gut Microbiota Metabolites That Modulate Host Physiology
Chen H, Nwe PK, Yang Y, Rosen CE, Bielecka AA, Kuchroo M, Cline GW, Kruse AC, Ring AM, Crawford JM, Palm NW. A Forward Chemical Genetic Screen Reveals Gut Microbiota Metabolites That Modulate Host Physiology. Cell 2019, 177: 1217-1231.e18. PMID: 31006530, PMCID: PMC6536006, DOI: 10.1016/j.cell.2019.03.036.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsHost physiologyBioactive microbial metabolitesHuman gut bacteriaHost sensingProlific producersG proteinsGut microbiota metabolitesBlood-brain barrierL-PheMicrobial metabolitesOrphan GPCRsGut bacteriaColonic motilityInhibitor administrationMicrobiota metabolitesIntestinal microbiotaSmall moleculesDietary histidineBacteriaPhysiologyMicrobiota metabolomeMetabolitesGPR97Orthogonal approachGPCRsImmunoglobulin A Coating Identifies Colitogenic Bacteria in Inflammatory Bowel Disease
Palm NW, de Zoete MR, Cullen TW, Barry NA, Stefanowski J, Hao L, Degnan PH, Hu J, Peter I, Zhang W, Ruggiero E, Cho JH, Goodman AL, Flavell RA. Immunoglobulin A Coating Identifies Colitogenic Bacteria in Inflammatory Bowel Disease. Cell 2014, 158: 1000-1010. PMID: 25171403, PMCID: PMC4174347, DOI: 10.1016/j.cell.2014.08.006.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsInflammatory bowel diseaseBowel diseaseIgA coatingIntestinal microbiotaIntestinal bacteriaGerm-free miceIBD patientsIntestinal diseaseImmunoglobulin AMouse modelDiseaseAnaerobic culturingDramatic susceptibilityTargeted eliminationDisease developmentDisease susceptibilityMiceCell sortingMicrobiotaBacterial cell sortingFecal bacteriaSuch bacteriaColitisPatientsIgA
2025
The subfornical organ is a nucleus for gut-derived T cells that regulate behaviour
Yoshida T, Nguyen M, Zhang L, Lu B, Zhu B, Murray K, Mineur Y, Zhang C, Xu D, Lin E, Luchsinger J, Bhatta S, Waizman D, Coden M, Ma Y, Israni-Winger K, Russo A, Wang H, Song W, Al Souz J, Zhao H, Craft J, Picciotto M, Grutzendler J, Distasio M, Palm N, Hafler D, Wang A. The subfornical organ is a nucleus for gut-derived T cells that regulate behaviour. Nature 2025, 1-10. PMID: 40437096, DOI: 10.1038/s41586-025-09050-7.Peer-Reviewed Original ResearchCitationsAltmetricConceptsMeningeal T cellsCentral nervous systemT cellsSubfornical organCD4 T cellsInnate immune compartmentGut-brain axisSteady-state brainGut microbiotaSpecialized immune cellsCentral nervous system homeostasisAdaptive immune systemBiological functionsImmune compartmentGut-derived T cellsImmune cellsWhite adiposeImmune systemNervous systemAdipose tissueComposition of adipose tissueGastrointestinal tissuesWell-characterizedHomeostasisBrainSkin damage signals mediate allergic sensitization to spatially unlinked antigen
Waizman D, Brown-Soler I, Martin A, Ma Y, Zhou K, Israni-Winger K, Zhang C, Medzhitov R, Launay P, Michieletto M, Henao-Mejia J, Palm N, Craft J, Eisenstein A, Wang A. Skin damage signals mediate allergic sensitization to spatially unlinked antigen. Science Immunology 2025, 10: eadn0688. PMID: 40184440, PMCID: PMC12100540, DOI: 10.1126/sciimmunol.adn0688.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsActivity of GPCR-targeted drugs influenced by human gut microbiota metabolism
Wu Q, Song D, Zhao Y, Verdegaal A, Turocy T, Duncan-Lowey B, Goodman A, Palm N, Crawford J. Activity of GPCR-targeted drugs influenced by human gut microbiota metabolism. Nature Chemistry 2025, 17: 808-821. PMID: 40181149, DOI: 10.1038/s41557-025-01789-w.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsGut commensal bacteriaCommensal bacteriaGut microbial communityGut microbiota metabolismDrug metabolismMetabolize drugsMicrobial communitiesIndividual speciesMetabolic modeMorganella morganiiMicrobiota metabolismGPCR-targeted drugsTricyclic systemThiophene motifsBacteria mixtureBacteriaMetabolomics investigationsMetabolismTargeting GPCRsDrug metabolitesPharmacological efficacyDrug transformationDrug structureDrugMetabolites
Academic Achievements & Community Involvement
Honors
honor Pew Scholar in the Biomedical Sciences
01/01/2019National AwardPew Charitable TrustsDetailsUnited Stateshonor Director's New Innovator Award (DP2)
01/01/2019National AwardNational Institutes of HealthDetailsUnited Stateshonor Smith Award for Excellence in Biomedical Research
01/01/2016Regional AwardRichard and Susan Smith Family FoundationDetailsUnited States
News & Links
News
- February 07, 2025Source: Yale News
Study Reveals How Gut Bacteria Might Trigger Autoimmune Diseases Like Lupus
- August 27, 2024
Gut Microbiome Imbalance Promotes Liver Disease in Cystic Fibrosis
- August 12, 2024
Protein in Mosquito Saliva Inhibits Host Immune Response
- July 11, 2024Source: Yale Ventures
11 Yale Projects Receive Awards from the Colton Center for Autoimmunity
Get In Touch
Contacts
Email
Academic Office Number
Mailing Address
Immunobiology
P.O. Box 208089
New Haven, CT 06520-8089
United States
Administrative Support
Locations
The Anlyan Center
Academic Office
300 Cedar Street, Ste 569, Rm C
New Haven, CT 06519
The Anlyan Center
Lab
300 Cedar Street, Ste 560
New Haven, CT 06519