Trevor Sorrells, PhD
Cards
Appointments
Contact Info
Yale School of Medicine
PO Box 208005
New Haven, CT 06520-8005
United States
About
Copy Link
Titles
Assistant Professor of Genetics
Biography
Trevor Sorrells received his B.S. in Biology from Stanford University in 2009. He completed his PhD in the lab of Alexander Johnson at the University of California, San Francisco where he pioneered molecular biological and genomic approaches in non-model yeast species to understand how transcription regulatory networks evolve. This work provided a mechanistic understanding of how network architecture and molecular function dictate the ways in which biological systems change over time. As a postdoctoral fellow with Leslie Vosshall at Rockefeller University, Trevor discovered a persistent behavioral state in the mosquito Aedes aegypti that sustains their pursuit of humans over time. To do this, he introduced optogenetics to study the brain of this important vector of disease. The Sorrells lab studies the neural circuits that control the ability of mosquitoes to bite humans and how this behavior evolved from their non-biting ancestors.
Appointments
Genetics
Assistant ProfessorPrimary
Other Departments & Organizations
Education & Training
- PhD
- University of California, San Francisco (2016)
- BS
- Stanford University (2009)
Research
Copy Link
Overview
Medical Research Interests
ORCID
0000-0002-3527-8622- View Lab Website
Sorrells Lab
Research at a Glance
Publications Timeline
Research Interests
Gene Regulatory Networks
Biological Evolution
Behavior, Animal
Publications
2025
A single-nucleus transcriptomic atlas of the adult Aedes aegypti mosquito
Goldman O, DeFoe A, Qi Y, Jiao Y, Weng S, Wick B, Houri-Zeevi L, Lakhiani P, Morita T, Razzauti J, Rosas-Villegas A, Tsitohay Y, Walker M, Hopkins B, Consortium A, Ang J, Antoshechkin I, Cai Y, Chen F, Chen Y, Devilliers J, Dong L, Feuda R, Gabrieli P, Kopp A, Kwon H, Li H, Lu T, Lucio T, Marques J, Oliveira M, Olmo R, Palatini U, Pithawala Z, Pompon J, Reis Y, Rodrigues J, Smith R, Haeussler M, Akbari O, Duvall L, White-Cooper H, Sorrells T, Sharma R, Li H, Vosshall L, Shai N. A single-nucleus transcriptomic atlas of the adult Aedes aegypti mosquito. Cell 2025, 188: 7267-7290.e26. PMID: 41172998, PMCID: PMC12767863, DOI: 10.1016/j.cell.2025.10.008.Peer-Reviewed Original ResearchCitationsAltmetricGlial cells diverge in fly brain evolution
Jiao Y, Sorrells T. Glial cells diverge in fly brain evolution. PLOS Biology 2025, 23: e3003136. PMID: 40305742, PMCID: PMC12043326, DOI: 10.1371/journal.pbio.3003136.Peer-Reviewed Original ResearchAltmetricCross-modal sensory compensation increases mosquito attraction to humans
Morita T, Lyn N, von Heynitz R, Goldman O, Sorrells T, DeGennaro M, Matthews B, Houri-Zeevi L, Vosshall L. Cross-modal sensory compensation increases mosquito attraction to humans. Science Advances 2025, 11: eadn5758. PMID: 39742477, PMCID: PMC11691641, DOI: 10.1126/sciadv.adn5758.Peer-Reviewed Original ResearchCitationsAltmetric
2022
A persistent behavioral state enables sustained predation of humans by mosquitoes
Sorrells T, Pandey A, Rosas-Villegas A, Vosshall L. A persistent behavioral state enables sustained predation of humans by mosquitoes. ELife 2022, 11: e76663. PMID: 35550041, PMCID: PMC9154740, DOI: 10.7554/elife.76663.Peer-Reviewed Original ResearchCitationsAltmetric
2020
Sensory Discrimination of Blood and Floral Nectar by Aedes aegypti Mosquitoes
Jové V, Gong Z, Hol F, Zhao Z, Sorrells T, Carroll T, Prakash M, McBride C, Vosshall L. Sensory Discrimination of Blood and Floral Nectar by Aedes aegypti Mosquitoes. Neuron 2020, 108: 1163-1180.e12. PMID: 33049200, PMCID: PMC9831381, DOI: 10.1016/j.neuron.2020.09.019.Peer-Reviewed Original ResearchCitationsAltmetricProtein-coding changes preceded cis-regulatory gains in a newly evolved transcription circuit
Britton C, Sorrells T, Johnson A. Protein-coding changes preceded cis-regulatory gains in a newly evolved transcription circuit. Science 2020, 367: 96-100. PMID: 31896718, PMCID: PMC8284397, DOI: 10.1126/science.aax5217.Peer-Reviewed Original ResearchCitationsAltmetric
2018
Intrinsic cooperativity potentiates parallel cis-regulatory evolution
Sorrells T, Johnson A, Howard C, Britton C, Fowler K, Feigerle J, Weil P, Johnson A. Intrinsic cooperativity potentiates parallel cis-regulatory evolution. ELife 2018, 7: e37563. PMID: 30198843, PMCID: PMC6173580, DOI: 10.7554/elife.37563.Peer-Reviewed Original ResearchCitationsAltmetric
2015
Intersecting transcription networks constrain gene regulatory evolution
Sorrells T, Booth L, Tuch B, Johnson A. Intersecting transcription networks constrain gene regulatory evolution. Nature 2015, 523: 361-365. PMID: 26153861, PMCID: PMC4531262, DOI: 10.1038/nature14613.Commentaries, Editorials and LettersCitationsAltmetricMeSH KeywordsBase SequenceBinding SitesDNA-Binding ProteinsDNA, FungalEnhancer Elements, GeneticEpistasis, GeneticEvolution, MolecularGene Expression Regulation, FungalGene Regulatory NetworksGenes, FungalKluyveromycesMating FactorPeptidesPheromonesPromoter Regions, GeneticSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsTranscription FactorsMaking Sense of Transcription Networks
Sorrells T, Johnson A. Making Sense of Transcription Networks. Cell 2015, 161: 714-723. PMID: 25957680, PMCID: PMC4531093, DOI: 10.1016/j.cell.2015.04.014.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsCitationsAltmetric
2013
Identification and characterization of a previously undescribed family of sequence-specific DNA-binding domains
Lohse M, Hernday A, Fordyce P, Noiman L, Sorrells T, Hanson-Smith V, Nobile C, DeRisi J, Johnson A. Identification and characterization of a previously undescribed family of sequence-specific DNA-binding domains. Proceedings Of The National Academy Of Sciences Of The United States Of America 2013, 110: 7660-7665. PMID: 23610392, PMCID: PMC3651432, DOI: 10.1073/pnas.1221734110.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords
Academic Achievements & Community Involvement
Copy Link
Honors
honor HHMI Freeman Hrabowski Scholar
09/01/2023National AwardHoward Hughes Medical Institutehonor NIAID New Innovator Award
08/01/2023National AwardNational Institutes of Healthhonor Bohmfalk Scholar
05/26/2023Yale School of Medicine AwardYale School of MedicineDetailsUnited Stateshonor Polak Young Investigator Award
04/20/2022International AwardAssociation for Chemoreception SciencesDetailsUnited Stateshonor Harold M. Weintraub Award
05/01/2016International AwardFred Hutchinson Cancer Center
News
Copy Link
News
Get In Touch
Copy Link
Contacts
Yale School of Medicine
PO Box 208005
New Haven, CT 06520-8005
United States
Administrative Support
Events
Yale Only Oliver Hobert
Yale Only Mara Lawniczak
Yale Only Eugenia Roberts - Christy Zheng
Yale Only Li Zhao