2025
Cerebrospinal fluid immune phenotyping reveals distinct immunotypes of myalgic encephalomyelitis/chronic fatigue syndrome.
Bastos V, Greene K, Tabachnikova A, Bhattacharjee B, Sjögren P, Bertilson B, Reifert J, Zhang M, Kamath K, Shon J, Gehlhausen J, Guan L, VanElzakker M, Proal A, Bragée B, Iwasaki A. Cerebrospinal fluid immune phenotyping reveals distinct immunotypes of myalgic encephalomyelitis/chronic fatigue syndrome. The Journal Of Immunology 2025 PMID: 40373264, DOI: 10.1093/jimmun/vkaf087.Peer-Reviewed Original ResearchMyalgic encephalomyelitis/chronic fatigue syndromeCerebrospinal fluidImmune phenotypeFatigue syndromeMatched healthy control subjectsAssessed plasma samplesMultiplex analysis of cytokinesHealthy control subjectsAnalysis of cerebrospinal fluidAnalysis of cytokinesTreatment developmentClinical presentationSymptom presentationMultiorgan diseaseInflammatory profileControl subjectsPathophysiological mechanismsMatrix metalloproteinase profilesDisease subgroupsME/CFS participantsClinical questionnaireMatrix metalloproteinasesMetalloproteinase profilesHigh-throughput microarrayPlasma samplesIncidence and Prevalence of Post-COVID-19 Myalgic Encephalomyelitis: A Report from the Observational RECOVER-Adult Study
Vernon S, Zheng T, Do H, Marconi V, Jason L, Singer N, Natelson B, Sherif Z, Bonilla H, Taylor E, Mullington J, Ashktorab H, Laiyemo A, Brim H, Patterson T, Akintonwa T, Sekar A, Peluso M, Maniar N, Bateman L, Horwitz L, Hess R. Incidence and Prevalence of Post-COVID-19 Myalgic Encephalomyelitis: A Report from the Observational RECOVER-Adult Study. Journal Of General Internal Medicine 2025, 40: 1085-1094. PMID: 39804551, PMCID: PMC11968624, DOI: 10.1007/s11606-024-09290-9.Peer-Reviewed Original ResearchSARS-CoV-2 infectionLongitudinal observational cohort studyClinical diagnostic criteriaSelf-reported symptomsResultsThe incidence rateBackgroundMyalgic encephalomyelitis/chronic fatigue syndromeTiming of SARS-CoV-2 infectionPost-exertional malaiseObservational cohort studyUninfected participantsPost-AcuteSARS-CoV-2Diagnostic criteriaCohort studyHazard ratioStudy visitsFatigue syndromeParticipantsEnhanced recoveryME/CFS symptomsLong COVIDMyalgic encephalomyelitisDays of infectionPrevalenceInfected participants
2024
Absence of BOLD adaptation in chronic fatigue syndrome revealed by task functional MRI
Schönberg L, Mohamed A, Yu Q, Kwiatek R, Del Fante P, Calhoun V, Shan Z. Absence of BOLD adaptation in chronic fatigue syndrome revealed by task functional MRI. Cerebrovascular And Brain Metabolism Reviews 2024, 45: 115-124. PMID: 39113421, PMCID: PMC11840696, DOI: 10.1177/0271678x241270528.Peer-Reviewed Original ResearchBlood oxygen level-dependentFunctional MRIME/CFS participantsHealthy controlsTask-based functional MRISymbol Digit Modalities TestFatigue syndromeRight postcentral gyrusTask functional MRIFMRI signal changesOxygen level-dependentMyalgic encephalomyelitis/chronic fatigue syndromeLeft primary motor cortexChronic fatigue syndromeTask blocksCognitive tasksPostcentral gyrusCognitive cortexBOLD adaptationNeurophysiological processesNeurophysiological mechanismsPrimary motor cortexLevel-dependentModal testingFatigue severityMyalgic Encephalomyelitis/Chronic Fatigue Syndrome After SARS-CoV-2 Infection
Unger E, Lin J, Wisk L, Yu H, L’Hommedieu M, Lavretsky H, Montoy J, Gottlieb M, Rising K, Gentile N, Santangelo M, Venkatesh A, Rodriguez R, Hill M, Geyer R, Kean E, Saydah S, McDonald S, Huebinger R, Idris A, Dorney J, Hota B, Spatz E, Stephens K, Weinstein R, Elmore J, Koo K, Derden A, Gatling K, Guzman D, Yang G, Kaadan A, Hassaballa M, Jerger R, Ahmed Z, Choi M, Pavlopoulos A, Kesari A, Gaylord C, Gomez C, Lomas E, Boliboun P, Patel K, Malicki C, Lin Z, Li S, Ebna Mannan I, Yang Z, Liu M, Ulrich A, Kinsman J, Pierce S, Puente X, Salah W, Nichol G, Anderson J, Schiffgens M, Morse D, Adams K, Stober T, Maat Z, O’Laughlin K, Willis M, Zhang Z, Chang G, Lyon V, Klabbers R, Ruiz L, Malone K, Park J, Renzi N, Watts P, Kelly M, Schaeffer K, Grau D, Cheng D, Shutty C, Charlton A, Shughart L, Shughart H, Amadio G, Miao J, Hannikainen P, Chandler C, Diaz Roldan K, Eguchi M, Moreno R, Wang R, Kemball R, Chan V, Lara Chavez C, Wong A, Arreguin M, Kane A, Nikonowicz P, Sapp S, Gallegos D, Martin K, Plumb I, Hall A, Briggs-Hagen M. Myalgic Encephalomyelitis/Chronic Fatigue Syndrome After SARS-CoV-2 Infection. JAMA Network Open 2024, 7: e2423555. PMID: 39046739, PMCID: PMC11270135, DOI: 10.1001/jamanetworkopen.2024.23555.Peer-Reviewed Original ResearchConceptsProportion of participantsMyalgic encephalomyelitis/chronic fatigue syndromeME/CFS symptomsFatigue syndromeIndex illnessMonths of follow-upCohort studySARS-CoV-2 infectionSelf-reported symptomsLongitudinal cohort studySARS-CoV-2 test resultsSurvey completion rateFollow-up surveyFollow-upProspective cohort studyCognitive problemsCOVID-19 positivitySARS-CoV-2SARS-CoV-2 testingTime of illnessMain OutcomesAdjusted analysesSocietal burdenCompletion ratesAcute SARS-CoV-2 infectionWhite-matter changes associated with a synergetic treatment for myalgic encephalomyelitis/chronic fatigue syndrome
Mohamed A, do Campo J, Del Fante P, Kwiatek R, Calhoun V, Shan Z. White-matter changes associated with a synergetic treatment for myalgic encephalomyelitis/chronic fatigue syndrome. Fatigue Biomedicine Health & Behavior 2024, 13: 8-18. DOI: 10.1080/21641846.2024.2367921.Peer-Reviewed Original ResearchMyalgic encephalomyelitis/chronic fatigue syndromeLow-dose naltrexoneFatigue syndromeWhite-matter tractsPre-treatment baselineDebilitating chronic illnessDeficit symptomsME/CFS patientsDiffusion-weighted imaging dataReducing depressionTreating ME/CFSSymptom improvementFractional anisotropyOff-label treatmentWhite-matter changesNaltrexoneNICE guidelinesPost-treatmentSymptomsME/CFSNeuroimaging characteristicsClinical measuresChronic illnessControl groupRandomized Controlled TrialsUnited States Veterans with comorbid chronic fatigue syndrome and chronic pain: do women differ from men?
Adamowicz J, Thomas E, Lund B, Driscoll M, Hadlandsmyth K. United States Veterans with comorbid chronic fatigue syndrome and chronic pain: do women differ from men? Fatigue Biomedicine Health & Behavior 2024, 12: 238-245. DOI: 10.1080/21641846.2024.2350301.Peer-Reviewed Original ResearchWomen veteransChronic fatigue syndromeChronic painVA Corporate Data WarehouseCorporate Data WarehousePsychiatric comorbiditiesFatigue syndromeGroup differencesEffect size differencesUnited States veteransPain clusterExamined group differencesHealthcare utilizationSociodemographic characteristicsPeriod prevalenceAdministrative dataClinical offeringsVeteransMenstrual painStates veteransPainWomenGroup comparisonsMenComorbidities
2023
A population-based investigation into the prevalence of chronic fatigue syndrome in United States military Veterans with chronic pain
Adamowicz J, Thomas E, Lund B, Driscoll M, Vander Weg M, Hadlandsmyth K. A population-based investigation into the prevalence of chronic fatigue syndrome in United States military Veterans with chronic pain. Fatigue Biomedicine Health & Behavior 2023, 11: 129-141. DOI: 10.1080/21641846.2023.2239977.Peer-Reviewed Original ResearchContext of chronic painVeterans Health AdministrationChronic fatigue syndromeChronic painSociodemographic characteristicsPrevalence of chronic fatigue syndromeMilitary veteransEffect sizeUnited States military veteransFatigue syndromeContext of CPDiagnosis of chronic fatigue syndromePopulation-based investigationChi-square test of independenceWeak effect sizesBetween-group comparisonsRural-dwellingBack painNon-HispanicHealthcare servicesHealth AdministrationChi-square testPeriod prevalencePersistent fatigueSample t-testExercise Pathophysiology in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and Postacute Sequelae of SARS-CoV-2 More in Common Than Not?
Joseph P, Singh I, Oliveira R, Capone C, Mullen M, Cook D, Stovall M, Squires J, Madsen K, Waxman A, Systrom D. Exercise Pathophysiology in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and Postacute Sequelae of SARS-CoV-2 More in Common Than Not? CHEST Journal 2023, 164: 717-726. PMID: 37054777, PMCID: PMC10088277, DOI: 10.1016/j.chest.2023.03.049.Peer-Reviewed Original ResearchConceptsMyalgic encephalomyelitis/chronic fatigue syndromeME/CFSChronic fatigue syndromeSARS-CoV-2Fatigue syndromePostacute sequelaeCardiopulmonary exercise testingSystemic blood flowExercise pathophysiologyExertional intoleranceIntractable fatigueExercise testingAcute infectionPostexertional malaiseExercise intoleranceOrthostatic intoleranceVentilatory controlLong-term consequencesBlood flowClinical overlapSuch symptomsIntoleranceSequelaeCOVID-19SyndromeDeficient butyrate-producing capacity in the gut microbiome is associated with bacterial network disturbances and fatigue symptoms in ME/CFS
Guo C, Che X, Briese T, Ranjan A, Allicock O, Yates R, Cheng A, March D, Hornig M, Komaroff A, Levine S, Bateman L, Vernon S, Klimas N, Montoya J, Peterson D, Lipkin W, Williams B. Deficient butyrate-producing capacity in the gut microbiome is associated with bacterial network disturbances and fatigue symptoms in ME/CFS. Cell Host & Microbe 2023, 31: 288-304.e8. PMID: 36758522, PMCID: PMC10183837, DOI: 10.1016/j.chom.2023.01.004.Peer-Reviewed Original ResearchConceptsME/CFSFaecalibacterium prausnitziiMyalgic encephalomyelitis/chronic fatigue syndromeFecal short-chain fatty acidsChronic fatigue syndromeShort-chain fatty acidsGut microbiome diversityGut dysbiosisGastrointestinal disturbancesTherapeutic trialsFatigue severityFatigue syndromeOrthostatic intoleranceValidation cohortHealthy controlsCognitive dysfunctionFatigue symptomsGut microbiomeDiverse cohortButyrate producersHuman gutPossible targetsEubacterium rectaleCohortMulti-omics analysis
2022
Unexplained post-acute infection syndromes
Choutka J, Jansari V, Hornig M, Iwasaki A. Unexplained post-acute infection syndromes. Nature Medicine 2022, 28: 911-923. PMID: 35585196, DOI: 10.1038/s41591-022-01810-6.Peer-Reviewed Original ResearchConceptsPost-acute sequelaeMyalgic encephalomyelitis/chronic fatigue syndromeSARS-CoV-2 infectionCertain acute infectionsMinority of patientsChronic fatigue syndromeSubstantial healthcare burdenSimilar symptom profilesSARS-CoV-2Common etiopathogenesisAcute infectionInfection syndromeClinical featuresFatigue syndromeChronic disabilityHealthcare burdenChronic illnessSymptom profilesInfectious agentsInfectionPotential involvementSequelaeSyndromeField of medicinePatientsAcute Effect of Pyridostigmine in Exertional Intolerance in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): A Randomized Placebo-Controlled Clinical Trial
Stovall M, Joseph P, Pari R, Warren A, Miller S, Squires J, Xiao W, Waxman A, Systrom D. Acute Effect of Pyridostigmine in Exertional Intolerance in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): A Randomized Placebo-Controlled Clinical Trial. 2022, a2063-a2063. DOI: 10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a2063.Peer-Reviewed Original Research
2021
Insights From Invasive Cardiopulmonary Exercise Testing of Patients With Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
Joseph P, Arevalo C, Oliveira RKF, Faria-Urbina M, Felsenstein D, Oaklander AL, Systrom DM. Insights From Invasive Cardiopulmonary Exercise Testing of Patients With Myalgic Encephalomyelitis/Chronic Fatigue Syndrome. CHEST Journal 2021, 160: 642-651. PMID: 33577778, PMCID: PMC8727854, DOI: 10.1016/j.chest.2021.01.082.Peer-Reviewed Original ResearchConceptsSmall fiber neuropathyRight atrial pressurePostural orthostatic tachycardiaMyalgic encephalomyelitis/chronic fatigue syndromeCardiopulmonary exercise testingChronic fatigue syndromeExertional intoleranceExercise testingFatigue syndromeControl subjectsOxygen extractionInvasive cardiopulmonary exercise testingLow right atrial pressureME/CFS criteriaHigh pulmonary blood flowME/CFS patientsPeripheral oxygen extractionSmall fiber pathologyPulmonary blood flowSystemic oxygen extractionCardiac returnIntrinsic heartNeurovascular dysregulationRight shuntingCFS patients
2020
Protective Effect of Hemin Against Experimental Chronic Fatigue Syndrome in Mice: Possible Role of Neurotransmitters
Thakur V, Jamwal S, Kumar M, Rahi V, Kumar P. Protective Effect of Hemin Against Experimental Chronic Fatigue Syndrome in Mice: Possible Role of Neurotransmitters. Neurotoxicity Research 2020, 38: 359-369. PMID: 32506340, DOI: 10.1007/s12640-020-00231-y.Peer-Reviewed Original ResearchMeSH Keywords3,4-Dihydroxyphenylacetic AcidAnimalsAnxietyBehavior, AnimalBrainDisease Models, AnimalDopamineElectron Transport Complex IElectron Transport Complex IIElevated Plus Maze TestEnzyme InhibitorsFatigue Syndrome, ChronicGlutathioneHand StrengthHeme Oxygenase-1HeminHomovanillic AcidHydroxyindoleacetic AcidLipid PeroxidationLocomotionMetalloporphyrinsMiceMitochondriaNeurotransmitter AgentsNitritesNorepinephrineProtoporphyrinsSerotoninConceptsChronic fatigue syndromeMitochondrial complex dysfunctionFatigue syndromeProtective effectComplex dysfunctionMale albino miceAnxiety-like behaviorFatigue-like behaviorAntifatigue effectNeurotransmitter alterationsCommon symptomsPresent studyNeurotransmitter levelsSwimming testAlbino miceExperimental miceImmobility periodEnzyme inhibitorsProtective roleCognitive impairmentLocomotor activityBehavioral testsSwimming sessionBiochemical parametersBiochemical alterations
2010
Endometriosis-associated Lyme
Matalliotakis I, Cakmak H, Ziogos M, Kalogeraki A, Kappou D, Arici A. Endometriosis-associated Lyme. Journal Of Obstetrics And Gynaecology 2010, 30: 184-186. PMID: 20143981, DOI: 10.3109/01443610903470270.Peer-Reviewed Original ResearchConceptsLyme diseaseIVF-ET procedureChronic fatigue syndromeCases of patientsSystemic lupusRheumatoid arthritisSjögren's syndromeFatigue syndromeMultiple sclerosisSerological findingsMedical filesEndocrine diseasesEndometriosisDiseaseSyndromeBorrelia burgdorferiWomenPatientsArthritisComplicationsSclerosisLupusPregnancyFeverMigraine
2008
Parvovirus
Landry M. Parvovirus. 2008, 183-193. DOI: 10.1128/9781555815455.ch9.Peer-Reviewed Original ResearchParvovirus B19 infectionParvovirus B19B19 infectionChronic fatigue syndromeTreatable causeAcute infectionChronic anemiaFatigue syndromeImmunocompetent hostsHuman bocavirusNeurologic syndromeIgG antibodiesCerebrospinal fluidRenal syndromeImmunoglobulin MBone marrowInfectionSyndromeB19Parvoviridae familyParvovirusHuman diseasesMinute virusVasculitisUveitis
2001
Abnormalities in response to vasopressin infusion in chronic fatigue syndrome
Altemus M, Dale J, Michelson D, Demitrack M, Gold P, Straus S. Abnormalities in response to vasopressin infusion in chronic fatigue syndrome. Psychoneuroendocrinology 2001, 26: 175-188. PMID: 11087963, DOI: 10.1016/s0306-4530(00)00044-5.Peer-Reviewed Original ResearchConceptsChronic fatigue syndromeCorticotropin-releasing hormoneHypothalamic CRH secretionFatigue syndromeCRH secretionACTH responseVasopressin infusionCortisol responsePeripheral infusionHour infusionACTH secretionNeuroendocrine abnormalitiesAdrenal axisHypothalamic secretionHypothalamus actsHealthy volunteersPrimary symptomsNeuroendocrine studiesArginine vasopressinInfusionSyndromePatientsSecretionVasopressinAbnormalities
1999
Idiopathic chronic fatigue and chronic fatigue syndrome: a comparison of two case-definitions.
Arpino C, Carrieri M, Valesini G, Pizzigallo E, Rovere P, Tirelli U, Conti F, Dialmi P, Barberio A, Rusconi N, Bosco O, Lazzarin A, Saracco A, Moro M, Vlahov D. Idiopathic chronic fatigue and chronic fatigue syndrome: a comparison of two case-definitions. Annali Dell Istituto Superiore Di Sanità 1999, 35: 435-41. PMID: 10721210.Peer-Reviewed Original ResearchConceptsChronic fatigue syndromeDefinition of CFSFatigue syndromeIdiopathic chronic fatigueNumber of patientsSymptoms of individualsAcute onsetSore throatSymptomatic onsetIdiopathic fatigueChronic fatigueInfectious processEligibility criteriaPatientsSyndromeSymptomsOnsetSignsLymphadenopathyPharyngitisFatigueCasesCriteriaIndividuals
1994
High titers of anti‐epstein‐barr virus DNA polymerase are found in patients with severe fatiguing illness
Natelson B, Ye N, Moul D, Jenkins F, Oren D, Tapp W, Cheng Y. High titers of anti‐epstein‐barr virus DNA polymerase are found in patients with severe fatiguing illness. Journal Of Medical Virology 1994, 42: 42-46. PMID: 8308519, DOI: 10.1002/jmv.1890420109.Peer-Reviewed Original ResearchConceptsChronic fatigue syndromeEpstein-Barr virusEBV DNA polymeraseSeasonal affective disorderAbnormal testsFatiguing illnessesSAD patientsSubset of patientsAbnormal titersCFS patientsSymptomatic patientsFatigue syndromePatient groupTreatment trialsHealthy controlsPatientsNormal rangeAffective disordersDisease severityUseful markerHigh titersAge rangeSocioeconomic classAntibodiesIllness
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