2025
Risk Factors Associated With Tuberculosis Infection Among Household Contacts of Patients With Microbiologically Confirmed Pulmonary Tuberculosis in 3 High Tuberculosis Burden Countries
Ntshiqa T, Nagudi J, Hamada Y, Copas A, Stender S, Sabi I, Ntinginya E, Lalashowi J, Matete M, Ntshamane K, Morojele I, Ngobeni M, Mudzengi D, Minja L, Chirwa T, Lönnroth K, Dreyer V, Niemann S, Rangaka M, Charalambous S, Velen K. Risk Factors Associated With Tuberculosis Infection Among Household Contacts of Patients With Microbiologically Confirmed Pulmonary Tuberculosis in 3 High Tuberculosis Burden Countries. The Journal Of Infectious Diseases 2025, 232: e448-e458. PMID: 40576297, PMCID: PMC12455307, DOI: 10.1093/infdis/jiaf320.Peer-Reviewed Original ResearchConceptsTuberculosis preventive therapyTuberculosis infectionPulmonary tuberculosisHousehold contactsPreventive therapyMicrobiologically confirmed PTBHousehold contacts of patientsWorld Health Organization criteriaQuantiFERON-TB Gold PlusTuberculosis infection prevalenceContacts of patientsTuberculosis burden countriesTuberculosis historyCross-sectional studyXpert UltraOrganization criteriaTherapy guidelinesBurden countriesRisk factorsHighest tuberculosis burden countriesTuberculosis prevalenceTuberculosisTherapyInfectionPrevalenceMental Health, Substance Use, and Tuberculosis Preventive Therapy in People With HIV: A Prospective Cohort Study
Johnson A, Chimoyi L, Shenoi S, Brault M, Forastiere L, Charalambous S, Chihota V, Davis J. Mental Health, Substance Use, and Tuberculosis Preventive Therapy in People With HIV: A Prospective Cohort Study. Open Forum Infectious Diseases 2025, 12: ofaf303. PMID: 40567997, PMCID: PMC12188208, DOI: 10.1093/ofid/ofaf303.Peer-Reviewed Original ResearchTuberculosis preventive therapyUnhealthy alcohol useMental healthDepressive symptomsAlcohol useTobacco useAssociation of mental healthInfluence of mental healthCohort studyMeasure symptoms of anxietyNegatively associated with adherenceDeductive content analysisMixed methods studySubstance useLongitudinal cohort studyPsychological support servicesSymptoms of anxietySymptoms of depressionPreventive therapyProspective cohort studyAntiretroviral therapyHIV mortalityMultivariate regression modelSubstance use disordersMethods studyEvaluating community knowledge of tuberculosis preventive therapy in rural South Africa
Foppiano Palacios C, Moll A, Shrestha R, Kompala T, Davis J, Charalambous S, Chimoyi L, Chihota V, Andrews L, Shenoi S. Evaluating community knowledge of tuberculosis preventive therapy in rural South Africa. BMC Public Health 2025, 25: 918. PMID: 40055618, PMCID: PMC11889810, DOI: 10.1186/s12889-025-21719-2.Peer-Reviewed Original ResearchConceptsKnowledge of TBTB knowledgeExploratory factor analysisCommunity membersPublic health educationRural South AfricaCross-sectional studyPreventive therapyTuberculosis preventive therapyMultivariate linear regressionLinear regressionHealth educationChi-square testMedian scoreCounseling effortsCommunity eventsDescriptive statisticsEvaluate knowledgeTesting initiativesCultural beliefsTB incidenceCommunity knowledgeKwaZulu NatalSouth AfricaFactor analysis
2023
Community health workers can be trained to identify patients eligible for tuberculosis preventive therapy, but encounter barriers to programme implementation in KwaZulu-Natal, South Africa
Norton S, Moll A, Madi J, Nkomo N, Brooks R, Andrews L, Shenoi S. Community health workers can be trained to identify patients eligible for tuberculosis preventive therapy, but encounter barriers to programme implementation in KwaZulu-Natal, South Africa. African Journal Of AIDS Research 2023, 22: 131-135. PMID: 37337826, DOI: 10.2989/16085906.2023.2213213.Peer-Reviewed Original ResearchConceptsTuberculosis preventive therapyCommunity health workersLargest HIV epidemicCause of deathNon-communicable diseasesHealth workersPreventive therapyRural resource-limited settingsHigh TB incidence ratesFurther implementation researchTB incidence rateRate of referralResource-limited settingsMedian ageTreatment initiationHIV epidemicIncidence rateRural South AfricaHIVInfectious diseasesTuberculosisImplementation researchScreening resultsDiseasePatients
2022
Community-based referral for tuberculosis preventive therapy is effective for treatment completion
Shenoi S, Kyriakides T, Dokubo E, Guddera V, Vranken P, Desai M, Friedland G, Moll A. Community-based referral for tuberculosis preventive therapy is effective for treatment completion. PLOS Global Public Health 2022, 2: e0001269. PMID: 36962910, PMCID: PMC10021376, DOI: 10.1371/journal.pgph.0001269.Peer-Reviewed Original ResearchTreatment completionCommunity-based identificationPreventive therapyIndependent predictorsGovernment primary care clinicsMedian age 35 yearsCommunity-based referralsHigher treatment completionMedian CD4 countTB preventive therapyTB endemic regionsTuberculosis preventive therapyComparison groupPrimary care clinicsClinic-based careAge 35 yearsCBR groupTeam of nursesSix-month courseMedian CD4Oral isoniazidCD4 countHIV careNight sweatsCare clinics
2021
Factors associated with low tuberculosis preventive therapy prescription rates among health care workers in rural South Africa
Ahmed AA, Grammatico M, Moll AP, Malinga S, Makhunga P, Charalambous S, Ladines-Lim JB, Jones J, Choi K, Shenoi SV. Factors associated with low tuberculosis preventive therapy prescription rates among health care workers in rural South Africa. Global Health Action 2021, 14: 1979281. PMID: 34652990, PMCID: PMC8525921, DOI: 10.1080/16549716.2021.1979281.Peer-Reviewed Original ResearchConceptsTuberculosis preventive therapyHealth care workersPrimary healthcare clinicsLower prescription ratesPrescription ratesRural South AfricaCare workersIsoniazid preventative therapyIncidence of tuberculosisCross-sectional studyGovernment district hospitalsPreventive therapyMedian ageMultivariable analysisPreventative therapyDistrict hospitalHealthcare clinicsHCW trainingPatient disclosureTPT useConsolidated FrameworkLogistic regressionImplementation researchSelf-reported dataPrescribers
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