2025
Associations between PM2.5 exposure and birth outcomes and effect modification by extreme heat events during pregnancy in a North Carolina cohort
Krajewski A, Alman B, Vaidyanathan A, Warren J, Luben T, Rappazzo K. Associations between PM2.5 exposure and birth outcomes and effect modification by extreme heat events during pregnancy in a North Carolina cohort. Atmospheric Environment 2025, 362: 121500. DOI: 10.1016/j.atmosenv.2025.121500.Peer-Reviewed Original ResearchBirth outcomesPreterm birthPM2.5 exposureExposure to extreme heat eventsPoor health outcomesBirth registry dataEffect measure modificationAdverse birth outcomesInteraction termsNorth Carolina cohortEntire pregnancyHealth outcomesGeocoded addressesSingleton birthsMeasure modificationEffect modificationBirth recordsCensus tractsRegistry dataTLBWRisk differenceNeonatal mortalityEnvironmental exposuresExposure dataWeeks gestationPermutation tests for detecting treatment effect heterogeneity in cluster randomized trials
Maleyeff L, Li F, Haneuse S, Wang R. Permutation tests for detecting treatment effect heterogeneity in cluster randomized trials. Statistical Methods In Medical Research 2025, 34: 1617-1632. PMID: 40525570, PMCID: PMC12365356, DOI: 10.1177/09622802251348999.Peer-Reviewed Original ResearchCluster randomized trialDetect treatment effect heterogeneityTreatment effect heterogeneityEffect heterogeneityNominal type I error rateRandomized trialsType I error rateTreatment-covariate interactionsAssess treatment effect heterogeneityTests of interaction termsPermutation testAverage treatment effectPain programEvaluation of intervention strategiesParametric assumptionsEffect modificationHealthcare ResearchActive copingSimulation studyTreatment effectsIntervention strategiesTrial contextPermutationInteraction termsTrialsJoint Exposure to Ozone and Temperature and Acute Myocardial Infarction Among Adults Aged 18 to 64 Years in the United States
Chu L, Wang R, Gross C, Wei J, Lu Y, Krumholz H, Ma X, Chen K. Joint Exposure to Ozone and Temperature and Acute Myocardial Infarction Among Adults Aged 18 to 64 Years in the United States. Circulation 2025, 152: 246-256. PMID: 40458867, PMCID: PMC12303734, DOI: 10.1161/circulationaha.124.073614.Peer-Reviewed Original ResearchIncident acute myocardial infarctionAcute myocardial infarctionIncreased oddsRisk of acute myocardial infarctionHigher risk of acute myocardial infarctionProbability of acute myocardial infarctionOccurrence of acute myocardial infarctionRandom-effects meta-analysisCase-crossover studyMultivariate random-effects meta-analysisExposure to ozoneRegion-specific estimatesMyocardial infarctionStatistical interaction termsAmbient ozone pollutionPrevention strategiesUnited StatesJoint exposureMeta-analysisAdult ageYoung adultsHigh riskAdultsOddsInteraction termsThe impact of race on the association between structural racism and the quality of non-small cell lung cancer (NSCLC).
Gaddy J, Lee D, Herrin J, Yu J, Pollack C, Dean L, Hamid S, Feder S, Canavan M, Soulos P, Gross C. The impact of race on the association between structural racism and the quality of non-small cell lung cancer (NSCLC). Journal Of Clinical Oncology 2025, 43: 1598-1598. DOI: 10.1200/jco.2025.43.16_suppl.1598.Peer-Reviewed Original ResearchPatient raceStructural racismNon-small cell lung cancerBlack patientsWhite patientsTwo-year survivalAppropriate evaluationSurveillance, EpidemiologyMixed effects logistic regression modelsMultivariable mixed effects logistic regression modelsEffects logistic regression modelsRegression modelsLogistic regression modelsLowest quintileHealth careRacial disparitiesRacial inequalityImpact of raceLocal stagingQuintileCell lung cancerMinoritized communitiesInteraction termsAssociationDisparitiesThe case-only design is a powerful approach to detect interactions but should be used with caution
Dong R, Wang G, DeWan A, Leal S. The case-only design is a powerful approach to detect interactions but should be used with caution. BMC Genomics 2025, 26: 222. PMID: 40050722, PMCID: PMC11884093, DOI: 10.1186/s12864-025-11318-1.Peer-Reviewed Original ResearchConceptsCase-only designRare disease assumptionType I error rateIncreased type I error ratesDisease prevalenceInvestigated type I errorComplex traitsInteraction termsInteraction effect sizesDetect interactionsCase-control designControlled type I error ratesSample sizeHigher disease prevalenceEffect sizeLow disease prevalenceType I errorPrevalenceExposure frequencyGenesType I andDesign studyEnvironmental factorsTraitsEnvironment interaction
2024
Impact of pandemic-related worries on mental health in India from 2020 to 2022
Yang Y, Sun A, Zimmermann L, Mukherjee B. Impact of pandemic-related worries on mental health in India from 2020 to 2022. Npj Mental Health Research 2024, 3: 57. PMID: 39582077, PMCID: PMC11586416, DOI: 10.1038/s44184-024-00101-x.Peer-Reviewed Original ResearchMental healthCalendar timeSelf-reported symptoms of depressionMental health outcomesPandemic-related worriesSymptoms of depressionMental health trendsSelf-reported symptomsHealth outcomesPublic health crisisHealth trendsEffect modifiersImpact SurveyResidential statusSocial media platformsFinancial stressHealth crisisWorryHealthInteraction termsMedia platformsAnxietyDepressionSurvey dataCalendar68-OR: Influence of the Type 1 Diabetes Genetic Risk Score on Response to Immunotherapies for Type 1 Diabetes Prevention
REDONDO M, BUNDY B, PARIKH H, YOU L, TRIOLO T, FERRAT L, TEMPLEMAN E, TOSUR M, STECK A, GOTTLIEB P, ONENGUT-GUMUSCU S, RICH S, ORAM R, HEROLD K, KRISCHER J. 68-OR: Influence of the Type 1 Diabetes Genetic Risk Score on Response to Immunotherapies for Type 1 Diabetes Prevention. Diabetes 2024, 73 DOI: 10.2337/db24-68-or.Peer-Reviewed Original ResearchT1D riskAssociated with higher risk of progressionMarkers of response to treatmentNon-HLA single nucleotide polymorphismsEvaluate risk-benefit ratiosHigh risk of progressionGenetic risk scoreSingle nucleotide polymorphismsCox modelType 1 diabetes genetic risk scoreResponse to immunotherapyRisk of progressionIncreased T1D riskAssociated with higher riskResponse to treatmentRisk-benefit ratioInteraction termsT1D preventionType 1 diabetes preventionPrevent T1DTreatment armsHazard ratioScore 2Treated armClinical trialsComorbidity Profiles of Posttraumatic Stress Disorder Across the Medical Phenome
Hicks E, Niarchou M, Goleva S, Kabir D, Johnson J, Johnston K, Ciarcia J, Pathak G, Smoller J, Davis L, Nievergelt C, Koenen K, Huckins L, Choi K, Group P. Comorbidity Profiles of Posttraumatic Stress Disorder Across the Medical Phenome. Biological Psychiatry Global Open Science 2024, 4: 100337. PMID: 39050781, PMCID: PMC11268109, DOI: 10.1016/j.bpsgos.2024.100337.Peer-Reviewed Original ResearchElectronic health recordsClinical knowledge gapsPhysical health problemsPhenome-wide associationPheWAS analysisBiobank participantsHealth recordsEpidemiological researchHealthcare systemTest associationsMedical phenomeAssociated with osteoporosisPulmonary heart diseasePhecodesHealth problemsLogistic regressionPosttraumatic stress disorderSex differencesPheWASComorbidity profilesHeart diseaseStress disorderInteraction termsAssociationPTSDComparison of mortality and amputation after lower extremity bypass versus peripheral vascular intervention in patients with chronic limb-threatening ischemia and comorbid chronic kidney disease
Cleman J, Sierra J, Romain G, Capuano B, Scierka L, Callegari S, Jacque F, Peri-Okonny P, Nagpal S, Smolderen K, Mena-Hurtado C. Comparison of mortality and amputation after lower extremity bypass versus peripheral vascular intervention in patients with chronic limb-threatening ischemia and comorbid chronic kidney disease. Journal Of Vascular Surgery 2024, 80: 480-489.e5. PMID: 38608966, PMCID: PMC11973903, DOI: 10.1016/j.jvs.2024.04.016.Peer-Reviewed Original ResearchChronic limb-threatening ischemiaAll-Cause MortalityLower extremity bypassPeripheral vascular interventionsComorbid chronic kidney diseaseLimb-threatening ischemiaComparison of mortalityPreference-sensitive treatment decisionsCox proportional hazards modelsRisk of deathInteraction termsProportional hazards modelLower-extremity bypassChronic kidney diseaseFine-Gray modelMortality riskVascular interventionsAmputationHazards modelOutcome dataFine-GrayAssociated with worse outcomesHigh riskKidney diseasePropensity scoreA unified framework for assessing interaction effects among environmental exposures in epidemiologic studies: A case study on temperature, air pollution, and kidney-related conditions in New York state
Chu L, Chen K, Yang Z, Crowley S, Dubrow R. A unified framework for assessing interaction effects among environmental exposures in epidemiologic studies: A case study on temperature, air pollution, and kidney-related conditions in New York state. Environmental Research 2024, 248: 118324. PMID: 38301759, DOI: 10.1016/j.envres.2024.118324.Peer-Reviewed Original ResearchAir pollutionMultiplicative interaction effectsNew York StateEstimated health burdenCase-crossover designEvaluation of effect modificationBi-variate associationsAssess interaction effectsConditional logistic modelMeasures of exposureInteraction effectsEffect modificationPollutionExposure variablesHealth burdenEpidemiological studiesEnvironmental exposuresLog-linear modelLogistic modelInteraction termsQuantitative frameworkAirCase studyExposureAlert system
2019
Does Information on Blood Heavy Metals Improve Cardiovascular Mortality Prediction?
Wang X, Mukherjee B, Park S. Does Information on Blood Heavy Metals Improve Cardiovascular Mortality Prediction? Journal Of The American Heart Association 2019, 8: e013571. PMID: 31631727, PMCID: PMC6898859, DOI: 10.1161/jaha.119.013571.Peer-Reviewed Original ResearchConceptsCardiovascular diseaseNational Health and Nutrition Examination SurveyHealth and Nutrition Examination SurveyRisk factorsStudy sampleCardiovascular disease risk factorsCardiovascular disease mortalityCardiovascular disease risk assessmentImprove CVD risk predictionC-statisticNutrition Examination SurveyCardiovascular mortality predictionCVD risk predictionCox modelBlood markersExamination SurveyPrecision healthRisk scorePairwise interaction termsBlood metalsIntegrated discrimination improvementRisk predictionReclassification improvementMortality predictionInteraction terms
2016
Mediation of the Relationship between Maternal Phthalate Exposure and Preterm Birth by Oxidative Stress with Repeated Measurements across Pregnancy
Ferguson K, Chen Y, VanderWeele T, McElrath T, Meeker J, Mukherjee B. Mediation of the Relationship between Maternal Phthalate Exposure and Preterm Birth by Oxidative Stress with Repeated Measurements across Pregnancy. Environmental Health Perspectives 2016, 125: 488-494. PMID: 27352406, PMCID: PMC5332184, DOI: 10.1289/ehp282.Peer-Reviewed Original ResearchConceptsExposure-mediator interactionPreterm birthMaternal phthalate exposureNested case-control study of preterm birthCase-control study of preterm birthNested Case-Control StudyPhthalate exposureStudy of preterm birthPhthalate metabolitesOxidative stressSpontaneous preterm birthLongitudinal measurementsMetabolites of di(2-ethylhexyl) phthalateOdds ratioRepeated measuresDi(2-ethylhexyl) phthalateMediation analysisRegression modelsOxidative stress biomarkersEstimated proportionPretermPregnancyInteraction termsBirthAssociation
2014
Testing departure from additivity in Tukey's model using shrinkage: application to a longitudinal setting
Ko Y, Mukherjee B, Smith J, Park S, Kardia S, Allison M, Vokonas P, Chen J, Diez‐Roux A. Testing departure from additivity in Tukey's model using shrinkage: application to a longitudinal setting. Statistics In Medicine 2014, 33: 5177-5191. PMID: 25112650, PMCID: PMC4227925, DOI: 10.1002/sim.6281.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAgingAtherosclerosisBone and BonesComputer SimulationEnvironmental ExposureEthnicityFemaleGene-Environment InteractionHumansIronLeadLeast-Squares AnalysisLikelihood FunctionsLongitudinal StudiesMaleMiddle AgedModels, GeneticUnited StatesUnited States Department of Veterans AffairsConceptsGene-environment interactionsMulti-Ethnic Study of AtherosclerosisModel of gene-environment interactionMulti-Ethnic StudyTukey's modelLongitudinal settingStudy of atherosclerosisNormative Aging StudyCase-control studyIncreasing categoriesAging StudyTested interactionsLongitudinal studyCategorical variablesRobust to misspecificationInteraction termsTest departuresShrinkage estimatorsWald testInteraction estimatesIncreased powerOne-degree-of-freedom modelInteraction effectsSetsEnvironmental markers
2007
Exploring interactive effects of genes and environments in etiology of individual differences in reading comprehension
Grigorenko EL, Deyoung CG, Getchell M, Haeffel GJ, Klinteberg BA, Koposov RA, Oreland L, Pakstis AJ, Ruchkin VV, Yrigollen CM. Exploring interactive effects of genes and environments in etiology of individual differences in reading comprehension. Development And Psychopathology 2007, 19: 1089-1103. PMID: 17931436, DOI: 10.1017/s0954579407000557.Peer-Reviewed Original ResearchConceptsIndividual differencesReading-related processesHigher-order cognitive skillsCatechol-O-methyltransferase (COMT) geneExecutive functioningCognitive processesCognitive skillsComprehension difficultiesAdolescent delinquentsMaternal rejectionComprehensionMain effectInteractive effectsImportant predictorCOMTHierarchical logistic regression modelsDelinquentsFunctioningSkillsReadingSuch processesInteraction termsPresence/absenceDifferencesPredictors
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