2025
Targeted transcriptomic analyses of tuberculosis treatment response and outcomes in The Gambia
Manneh I, Darboe F, Jobe H, Kuyateh B, Cham O, Owolabi O, Kotanmi B, Rachow A, Charalambous S, Held K, Dockrell H, Sutherland J. Targeted transcriptomic analyses of tuberculosis treatment response and outcomes in The Gambia. Frontiers In Tuberculosis 2025, 3: 1540194. DOI: 10.3389/ftubr.2025.1540194.Peer-Reviewed Original ResearchArea under the curvePoor treatment outcomesTreatment responseTreatment outcomesMonth 2Week 2Drug-susceptible tuberculosisTB treatment responseTuberculosis treatment responseEffective treatment regimensGene expressionMonitor treatment outcomesDetection of mycobacteriaTreatment regimensGood outcomeTB treatmentGene signaturePatientsTreatment monitoringPAXgene tubesRNA gene expressionDiagnosisGene expression differencesFast respondersTuberculosisA streamlined CRISPR-based test for tuberculosis detection directly from sputum
Bell A, Dunkley O, Modi N, Huang Y, Tseng S, Reiss R, Daivaa N, Davis J, Vargas D, Banada P, Xie Y, Myhrvold C. A streamlined CRISPR-based test for tuberculosis detection directly from sputum. Science Advances 2025, 11: eadx2067. PMID: 40768573, PMCID: PMC12327463, DOI: 10.1126/sciadv.adx2067.Peer-Reviewed Original ResearchThe participation of people deprived of liberty in tuberculosis vaccine trials: should they be protected from research, or through research?
Andrews J, Charalambous S, Churchyard G, Cobelens F, Fernández-Escobar C, Frick M, Hanekom W, Hatherill M, Hill P, Pandey S, Rangaka M, White R, Lemos E, da Silva A, Croda J, Garcia-Basteiro A. The participation of people deprived of liberty in tuberculosis vaccine trials: should they be protected from research, or through research? The Lancet Infectious Diseases 2025 PMID: 40587989, DOI: 10.1016/s1473-3099(25)00305-6.Peer-Reviewed Original ResearchTuberculosis vaccine trialVaccine trialsHigh riskEffective tuberculosis vaccineHigh risk of developing diseaseAdult pulmonary tuberculosisRate of tuberculosisRisk of developing diseaseMycobacterium tuberculosis transmissionPulmonary tuberculosisClinical developmentTuberculosis vaccinesMedical researchEthical violationsLiberty rightsTuberculosis transmissionEfficacy trialsTuberculosisTuberculosis controlScientific progressLibertyPlanned trialsTrialsParticipation of peopleVaccineRisk Factors Associated With Tuberculosis Infection Among Household Contacts of Patients With Microbiologically Confirmed Pulmonary Tuberculosis in 3 High Tuberculosis Burden Countries
Ntshiqa T, Nagudi J, Hamada Y, Copas A, Stender S, Sabi I, Ntinginya E, Lalashowi J, Matete M, Ntshamane K, Morojele I, Ngobeni M, Mudzengi D, Minja L, Chirwa T, Lönnroth K, Dreyer V, Niemann S, Rangaka M, Charalambous S, Velen K. Risk Factors Associated With Tuberculosis Infection Among Household Contacts of Patients With Microbiologically Confirmed Pulmonary Tuberculosis in 3 High Tuberculosis Burden Countries. The Journal Of Infectious Diseases 2025, 232: e448-e458. PMID: 40576297, PMCID: PMC12455307, DOI: 10.1093/infdis/jiaf320.Peer-Reviewed Original ResearchConceptsTuberculosis preventive therapyTuberculosis infectionPulmonary tuberculosisHousehold contactsPreventive therapyMicrobiologically confirmed PTBHousehold contacts of patientsWorld Health Organization criteriaQuantiFERON-TB Gold PlusTuberculosis infection prevalenceContacts of patientsTuberculosis burden countriesTuberculosis historyCross-sectional studyXpert UltraOrganization criteriaTherapy guidelinesBurden countriesRisk factorsHighest tuberculosis burden countriesTuberculosis prevalenceTuberculosisTherapyInfectionPrevalenceBedaquiline Adherence Predicts Retention-in-Care in Patients With Drug-Resistant Tuberculosis and HIV
Lam S, Wolf A, Lu X, Zelnick J, Amico K, Guzman K, Perumal R, Zulu M, Friedland G, Daftary A, Seepamore B, Naidoo K, O'Donnell M. Bedaquiline Adherence Predicts Retention-in-Care in Patients With Drug-Resistant Tuberculosis and HIV. American Journal Of Respiratory And Critical Care Medicine 2025, 211: a1035-a1035. DOI: 10.1164/ajrccm.2025.211.abstracts.a1035.Peer-Reviewed Original ResearchSocio-ecologic Factors Impacting Medication Adherence Trajectories in Patients With Drug-resistant Tuberculosis and Human Immunodeficiency Virus
Guzman K, Wolf A, Perumal R, Cummings M, Zulu M, Zelnick J, Friedland G, Amico K, Reis K, Cheung Y, Daftary A, Seepamore B, Naidoo K, O'Donnell M. Socio-ecologic Factors Impacting Medication Adherence Trajectories in Patients With Drug-resistant Tuberculosis and Human Immunodeficiency Virus. American Journal Of Respiratory And Critical Care Medicine 2025, 211: a1036-a1036. DOI: 10.1164/ajrccm.2025.211.abstracts.a1036.Peer-Reviewed Original ResearchIntegrating genomic and spatial analyses to describe tuberculosis transmission: a scoping review
Lan Y, Rancu I, Chitwood M, Sobkowiak B, Nyhan K, Lin H, Wu C, Mathema B, Brown T, Colijn C, Warren J, Cohen T. Integrating genomic and spatial analyses to describe tuberculosis transmission: a scoping review. The Lancet Microbe 2025, 6: 101094. PMID: 40228509, PMCID: PMC12371702, DOI: 10.1016/j.lanmic.2025.101094.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsGenome sequencing approachGenetic similarityGenomic dataSequencing approachGenotyping methodsPathogen geneticsGenetic methodsPathogen sequencesSampling completenessTuberculosis isolatesTransmission patternsTuberculosis casesPathogensTuberculosis transmissionM tuberculosis isolatesInfection-related mortalityEnvironmental factorsTuberculosis transmission dynamicsSpatial proximityTransmission clustersGenomeSpatial patternsTuberculosisTransmission dynamicsGeneticsPulmonary Infections in People with HIV
Grammatico M, Shenoi S, Lemieux S, Akgün K. Pulmonary Infections in People with HIV. 2025, 793-819. DOI: 10.1007/978-3-031-77335-8_31.Peer-Reviewed Original ResearchEffect of digital adherence technologies on treatment outcomes in people with drug-susceptible tuberculosis: four pragmatic, cluster-randomised trials
Jerene D, van Kalmthout K, Levy J, Alacapa J, Deyanova N, Dube T, Mganga A, Tasca B, Bogdanov A, Efo E, Gamazina K, Garfin A, Kochanov V, Leung A, Madden N, Maraba N, McQuaid C, Mleoh L, Onjare B, Powers R, Terleiva Y, van Rest J, Gebhard A, Fielding K, Charalambous S. Effect of digital adherence technologies on treatment outcomes in people with drug-susceptible tuberculosis: four pragmatic, cluster-randomised trials. The Lancet 2025, 405: 1155-1166. PMID: 40086457, DOI: 10.1016/s0140-6736(24)02847-2.Peer-Reviewed Original ResearchDrug-susceptible tuberculosisTreatment outcomesPoor treatment outcomesPrimary outcomeDigital adherence technologiesIntervention armCluster randomised trialIntention-to-treat populationStandard of care armTuberculosis treatment outcomesDocumented treatment failureLoss to follow-upStandard of careAdherence technologiesTreatment failureTreatment startAdult patientsFollow-upPatientsTreatment statusPatient outcomesCare armTuberculosisMedicationTrialsTuberculosis of the Wrist- I Wasn’t in Good Hands
Haroon J, Donohue K, Laskin W, Golden M. Tuberculosis of the Wrist- I Wasn’t in Good Hands. Journal Of Orthopaedic Reports 2025, 100654. DOI: 10.1016/j.jorep.2025.100654.Peer-Reviewed Original Research
2024
Unlocking the potential of miRNAs in detecting pulmonary tuberculosis: prospects and pitfalls
Arya R, Kumar S, Vinetz J, Kim J, Chaurasia R. Unlocking the potential of miRNAs in detecting pulmonary tuberculosis: prospects and pitfalls. Expert Reviews In Molecular Medicine 2024, 26: e32. PMID: 39639643, PMCID: PMC11629464, DOI: 10.1017/erm.2024.29.Peer-Reviewed Original ResearchConceptsDisease stageHIV Co-InfectionAnti-TB therapyPotential of miRNAsInfectious diseasesPulmonary TBPulmonary tuberculosisActive TBFalse-positive outcomesTB diagnosticsDisease progressionLack of specificityPrognostic signatureCo-InfectionLethal infectious diseaseDeadliest infectious diseasesPoint-of-care testingTuberculosisDiagnostic biomarkersStandard protocolDiseaseBiomarkersGene expressionNon-invasiveRegulatory roleExhaled breath analysis: A promising triage test for tuberculosis in young children
Bijker E, Smith J, Mchembere W, McCarthy K, Oord H, Gerritsen J, Click E, Cain K, Song R. Exhaled breath analysis: A promising triage test for tuberculosis in young children. Tuberculosis 2024, 149: 102566. PMID: 39332067, PMCID: PMC11864270, DOI: 10.1016/j.tube.2024.102566.Peer-Reviewed Original ResearchTriage testPaediatric pulmonary tuberculosisRespiratory tract infectionsSymptoms of tuberculosisDiagnose respiratory tract infectionsCross-sectional studyExpectorated sputumTract infectionsPulmonary tuberculosisPaediatric tuberculosisDiagnostic accuracyBreath testYoung childrenYoung infantsTuberculosisExhaled breath analysisBreathingBreath analysisChildrenTriageExhaled breathSputumInfantsWHO global research priorities for antimicrobial resistance in human health
Bertagnolio S, Dobreva Z, Centner C, Olaru I, Donà D, Burzo S, Huttner B, Chaillon A, Gebreselassie N, Wi T, Hasso-Agopsowicz M, Allegranzi B, Sati H, Ivanovska V, Kothari K, Balkhy H, Cassini A, Hamers R, Van Weezenbeek K, Collaborators W, Aanensen D, Alanio A, Alastruey-Izquierdo A, Alemayehu T, Al-Hasan M, Allegaert K, Al-Maani A, Al-Salman J, Alshukairi A, Amir A, Applegate T, Araj G, Villalobos M, Årdal C, Ashiru-Oredope D, Ashley E, Babin F, Bachmann L, Bachmann T, Baker K, Balasegaram M, Bamford C, Baquero F, Barcelona L, Bassat Q, Bassetti M, Basu S, Beardsley J, Vásquez G, Berkley J, Bhatnagar A, Bielicki J, Bines J, Bongomin F, Bonomo R, Bradley J, Bradshaw C, Brett A, Brink A, Brown C, Brown J, Buising K, Carson C, Carvalho A, Castagnola E, Cavaleri M, Cecchini M, Chabala C, Chaisson R, Chakrabarti A, Chandler C, Chandy S, Charani E, Chen L, Chiara F, Chowdhary A, Chua A, Chuki P, Chun D, Churchyard G, Cirillo D, Clack L, Coffin S, Cohn J, Cole M, Conly J, Cooper B, Corso A, Cosgrove S, Cox H, Daley C, Darboe S, Darton T, Davies G, de Egea V, Dedeić-Ljubović A, Deeves M, Denkinger C, Dillon J, Dramowski A, Eley B, Esposito S, Essack S, Farida H, Farooqi J, Feasey N, Ferreyra C, Fifer H, Finlayson H, Frick M, Gales A, Galli L, Gandra S, Gerber J, Giske C, Gordon B, Govender N, Guessennd N, Guindo I, Gurbanova E, Gwee A, Hagen F, Harbarth S, Haze J, Heim J, Hendriksen R, Heyderman R, Holt K, Hönigl M, Hook E, Hope W, Hopkins H, Hughes G, Ismail G, Issack M, Jacobs J, Jasovský D, Jehan F, Pearson A, Jones M, Joshi M, Kapil A, Kariuki S, Karkey A, Kearns G, Keddy K, Khanna N, Kitamura A, Kolho K, Kontoyiannis D, Kotwani A, Kozlov R, Kranzer K, Kularatne R, Lahra M, Langford B, Laniado-Laborin R, Larsson J, Lass-Flörl C, Le Doare K, Lee H, Lessa F, Levin A, Limmathurotsakul D, Lincopan N, Vecchio A, Lodha R, Loeb M, Longtin Y, Lye D, Mahmud A, Manaia C, Manderson L, Mareković I, Marimuthu K, Martin I, Mashe T, Mei Z, Meis J, De Melo F, Mendelson M, Miranda A, Moore D, Morel C, Moremi N, Moro M, Moussy F, Mshana S, Mueller A, Ndow F, Nicol M, Nunn A, Obaro S, Obiero C, Okeke I, Okomo U, Okwor T, Oladele R, Omulo S, Ondoa P, de Canese J, Ostrosky-Zeichner L, Padoveze M, Pai M, Park B, Parkhill J, Parry C, Peeling R, Peixe L, Perovic O, Pettigrew M, Principi N, Pulcini C, Puspandari N, Rawson T, Reddy D, Reddy K, Redner P, Tudela J, Rodríguez-Baño J, Van Katwyk S, Roilides E, Rollier C, Rollock L, Ronat J, Ruppe E, Sadarangani M, Salisbury D, Salou M, Samison L, Sanguinetti M, Sartelli M, Schellack N, Schouten J, Schwaber M, Seni J, Senok A, Shafer W, Shakoor S, Sheppard D, Shin J, Sia S, Sievert D, Singh I, Singla R, Skov R, Soge O, Sprute R, Srinivasan A, Srinivasan S, Sundsfjord A, Tacconelli E, Tahseen S, Tangcharoensathien V, Tängdén T, Thursky K, Thwaites G, de Souza Peral R, Tong D, Tootla H, Tsioutis C, Turner K, Turner P, Omar S, van de Sande W, van den Hof S, van Doorn R, Veeraraghavan B, Verweij P, Wahyuningsih R, Wang H, Warris A, Weinstock H, Wesangula E, Whiley D, White P, Williams P, Xiao Y, Moscoso M, Yang H, Yoshida S, Yu Y, Żabicka D, Zignol M, Rudan I. WHO global research priorities for antimicrobial resistance in human health. The Lancet Microbe 2024, 5: 100902. PMID: 39146948, PMCID: PMC11543637, DOI: 10.1016/s2666-5247(24)00134-4.Peer-Reviewed Original ResearchAntimicrobial resistanceTreatment of antimicrobial-resistant infectionsConsequences of antimicrobial resistanceAntimicrobial resistance epidemiologyAntimicrobial-resistant infectionsDrug-resistant pathogensAntimicrobial resistance dynamicsResearch prioritiesComprehensive scoping reviewGeneration of evidenceGlobal research prioritiesScoping ReviewWHOKnowledge gapsExpert inputResearch agendaHealthBurdenPathogensFungal pathogensPolicy translationTuberculosisDiagnosisInfectionPotential of Pan-Tuberculosis Treatment to Drive Emergence of Novel Resistance - Volume 30, Number 8—August 2024 - Emerging Infectious Diseases journal - CDC
McQuaid C, Ryckman T, Menzies N, White R, Cohen T, Kendall E. Potential of Pan-Tuberculosis Treatment to Drive Emergence of Novel Resistance - Volume 30, Number 8—August 2024 - Emerging Infectious Diseases journal - CDC. Emerging Infectious Diseases 2024, 30: 1571-1579. PMID: 39043388, PMCID: PMC11286077, DOI: 10.3201/eid3008.240541.Peer-Reviewed Original ResearchConceptsResistance to novel drugsStandard of careAntimicrobial resistanceIncreasing prevalence of antimicrobial resistancePrevalence of antimicrobial resistanceIncreased prevalenceDrug susceptibility testingCompare treatment outcomesFirst-line drugsNovel drugsTB patient cohortTreatment regimensPatient cohortNew tuberculosisRegimensTreatment outcomesComponent drugsDrugCohortTuberculosisCDCUniversal useClinicCarePrevalenceAirway microbiome signature accurately discriminates Mycobacterium tuberculosis infection status
Kayongo A, Ntayi M, Olweny G, Kyalo E, Ndawula J, Ssengooba W, Kigozi E, Kalyesubula R, Munana R, Namaganda J, Caroline M, Sekibira R, Bagaya B, Kateete D, Joloba M, Jjingo D, Sande O, Mayanja-Kizza H. Airway microbiome signature accurately discriminates Mycobacterium tuberculosis infection status. IScience 2024, 27: 110142. PMID: 38904070, PMCID: PMC11187240, DOI: 10.1016/j.isci.2024.110142.Peer-Reviewed Original ResearchImmune responseQuantiferon-gold assayMicrobiome signaturesLonger treatment durationTuberculosis infection statusInfection statusDeadly infectious agentsQuantiferon GoldDrug toxicityActive TBLatent TBTreatment durationTherapeutic strategiesPredicting disease susceptibilityFollow-up phaseAirwayMicrobiome diversityInfectious agentsRural UgandaControl TBMycobacterium tuberculosisDisease susceptibilityCohortTuberculosisGeneXpertRandomized Controlled Trial of Integrated Adherence Support to Improve Treatment Outcomes in Patients With Drug-resistant Tuberculosis and HIV
Perumal R, Wolf A, Zelnick J, Friedland G, Amico R, Daftary A, Boodhram R, Padayatchi N, Naidoo K, O'Donnell M. Randomized Controlled Trial of Integrated Adherence Support to Improve Treatment Outcomes in Patients With Drug-resistant Tuberculosis and HIV. 2024, a6948-a6948. DOI: 10.1164/ajrccm-conference.2024.209.1_meetingabstracts.a6948.Peer-Reviewed Original ResearchFeasibility and utility of a combined nasogastric-tube-and-string-test device for bacteriologic confirmation of pulmonary tuberculosis in young children
Khambati N, Song R, Smith J, Bijker E, McCarthy K, Click E, Mchembere W, Okumu A, Musau S, Okeyo E, Perez-Velez C, Cain K. Feasibility and utility of a combined nasogastric-tube-and-string-test device for bacteriologic confirmation of pulmonary tuberculosis in young children. Diagnostic Microbiology And Infectious Disease 2024, 109: 116302. PMID: 38657352, PMCID: PMC11128341, DOI: 10.1016/j.diagmicrobio.2024.116302.Peer-Reviewed Original ResearchThe recent rapid expansion of multidrug resistant Ural lineage Mycobacterium tuberculosis in Moldova
Chitwood M, Colijn C, Yang C, Crudu V, Ciobanu N, Codreanu A, Kim J, Rancu I, Rhee K, Cohen T, Sobkowiak B. The recent rapid expansion of multidrug resistant Ural lineage Mycobacterium tuberculosis in Moldova. Nature Communications 2024, 15: 2962. PMID: 38580642, PMCID: PMC10997638, DOI: 10.1038/s41467-024-47282-9.Peer-Reviewed Original ResearchConceptsMDR M. tuberculosisGenome sequenceResistance-conferring mutationsBeijing sublineageMDR strainsReproductive fitnessBeijing strainsCulture-positive casesLineagesMTB strainsMultidrug-resistant tuberculosisMDRMtbStrainMDR-TBMutationsResistant tuberculosisMDR-MTBSubstantial riskSublineagesTuberculosisSequenceSerial Mass Screening for Tuberculosis Among Incarcerated Persons in Brazil
de Araujo R, Martinez L, da Silva Santos A, Lemos E, de Oliveira R, Croda M, Silva D, Lemes I, Cunha E, Gonçalves T, dos Santos P, da Silva B, Gonçalves C, Andrews J, Croda J. Serial Mass Screening for Tuberculosis Among Incarcerated Persons in Brazil. Clinical Infectious Diseases 2024, 78: 1669-1676. PMID: 38324908, PMCID: PMC11175667, DOI: 10.1093/cid/ciae055.Peer-Reviewed Original ResearchScreening roundsIncarcerated personsMass screeningIndividual prisonersIncarcerated peoplePrison populationBrazilian prisonsCases of pulmonary tuberculosisHigh-risk populationPrisonHealth QuestionnaireChest X-rayImprove case detectionPrevalence of tuberculosisRate of tuberculosisTB screeningMedian scoreHyperendemic settingsPulmonary tuberculosisXpert MTB/RIFTB scoreTuberculosis casesTuberculosis burdenCase detectionTuberculosisBrief Report: Differentiated Service Delivery Framework for People With Multidrug-Resistant Tuberculosis and HIV Coinfection
Reis K, Wolf A, Perumal R, Seepamore B, Guzman K, Ross J, Cheung Y, Amico K, Brust J, Padayatchi N, Friedland G, Naidoo K, Daftary A, Zelnick J, O'Donnell M. Brief Report: Differentiated Service Delivery Framework for People With Multidrug-Resistant Tuberculosis and HIV Coinfection. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2024, 96: 34-39. PMID: 38323838, PMCID: PMC11300702, DOI: 10.1097/qai.0000000000003394.Peer-Reviewed Original ResearchMultidrug-resistant tuberculosisDifferentiated service deliveryAntiretroviral therapyElectronic dose monitoring devicesAntiretroviral therapy adherenceMultidrug-resistant tuberculosis treatmentDifferentiated service delivery modelsHIV Co-InfectionTreatment courseCumulative adherenceTreatment challengesCo-InfectionBedaquilineTreatment completionFocus groupsMedication adherenceHIVTreatmentPatterns of medication adherenceAdherenceTuberculosisSubpopulationsHIV/AIDSTreatment stageStage-specific
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