2025
Effects of Prenatal Exposure to PM2.5 Chemical Components on Adverse Birth Outcomes and Under-5 Mortality in South Korea
Byun G, Choi Y, Lee J, Bell M. Effects of Prenatal Exposure to PM2.5 Chemical Components on Adverse Birth Outcomes and Under-5 Mortality in South Korea. Epidemiology 2025, 36: 531-540. PMID: 40257114, PMCID: PMC12118620, DOI: 10.1097/ede.0000000000001868.Peer-Reviewed Original ResearchMeSH KeywordsAdultAir PollutantsChild MortalityChild, PreschoolFemaleHumansInfantInfant MortalityInfant, Low Birth WeightInfant, NewbornInfant, Small for Gestational AgeLogistic ModelsMaleMaternal ExposureParticulate MatterPregnancyPregnancy OutcomePremature BirthPrenatal Exposure Delayed EffectsRepublic of KoreaConceptsAdverse birth outcomesAssociated with adverse birth outcomesBirth outcomesRisk of preterm birthExposure to PMPreterm birthLow birth weightAssociated with increased odds of PTBIncreased risk of PTBOdds of preterm birthAssociations of prenatal exposureUnder-5 MortalityExposure to fine particulate matterPopulation of South KoreaAssociated with increased oddsPrenatal exposureAge 5 yearsDeath recordsBirth weightBirth recordsUnder-5Pregnancy exposureEffects of prenatal exposureEffect estimatesLogistic regression
2024
Functional Connectivity Relationships to Longitudinal Motor Outcomes Differ in Very Preterm Children With and Without Brain Injury
Cyr P, Lean R, Kenley J, Kaplan S, Meyer D, Neil J, Alexopoulos D, Brady R, Shimony J, Rodebaugh T, Rogers C, Smyser C. Functional Connectivity Relationships to Longitudinal Motor Outcomes Differ in Very Preterm Children With and Without Brain Injury. Neurology Clinical Practice 2024, 15: e200397. PMID: 39439574, PMCID: PMC11492901, DOI: 10.1212/cpj.0000000000200397.Peer-Reviewed Original ResearchTerm-equivalent ageVery preterm childrenVery pretermChildren born very pretermBayley Scales of Infant DevelopmentMotor deficitsObservational cohort studyBrain injuryLongitudinal observational cohort studyAge 2 yearsAge 5 yearsStructural MRI findingsFine motor scoresNeonatal periodMRI findingsFunctional connectivityBayley ScalesFollow-upCohort studySD decreaseIncreased oddsInjured groupOutcome differencesMotor scoresUninjured groupTest and treat approach for tuberculosis infection amongst household contacts of drug-susceptible pulmonary tuberculosis, Mumbai, India
Shah D, Bhide S, Deshmukh R, Smith J, Kaiplyawar S, Puri V, Yeldandi V, Date A, Nyendak M, Ho C, Moonan P. Test and treat approach for tuberculosis infection amongst household contacts of drug-susceptible pulmonary tuberculosis, Mumbai, India. Frontiers In Tuberculosis 2024, 2: 1454277. PMID: 39421397, PMCID: PMC11485165, DOI: 10.3389/ftubr.2024.1454277.Peer-Reviewed Original ResearchInterferon-gamma release assayTB preventive treatmentTB infectionHousehold contactsDrug-susceptible pulmonary tuberculosisTB diseaseTreat approachProgression to active TB diseaseDrug-susceptible pulmonary TBRate of TB infectionPrevalence of TB infectionActive TB diseaseAge 5 yearsSecondary TB casesCross-sectional studyAntituberculosis treatmentIGRA testPulmonary TBPulmonary tuberculosisTuberculosis infectionInterferon-gammaRelease assayClinical evaluationEarly diagnosisTreat strategy
2023
Neonatal Intensive Care Unit Latent Profiles of Maternal Distress: Associations With 5-Year Maternal and Child Mental Health Outcomes
Njoroge W, Gerstein E, Lean R, Paul R, Smyser C, Rogers C. Neonatal Intensive Care Unit Latent Profiles of Maternal Distress: Associations With 5-Year Maternal and Child Mental Health Outcomes. Journal Of The American Academy Of Child & Adolescent Psychiatry 2023, 62: 1123-1133. PMID: 37084882, PMCID: PMC10543383, DOI: 10.1016/j.jaac.2023.02.015.Peer-Reviewed Original ResearchConceptsNeonatal intensive care unitChild mental health outcomesPreterm infantsHealth outcomesMental health outcomesNICU stressReference listsHealth factorsSocial determinantsChildren age 5 yearsHigher depressionIntensive care unitLife stressDisparate health outcomesPoor health outcomesAge 5 yearsEthnic groupsNICU dischargeCare unitRisk dyadsChildren ages 5Clinical riskUniversal screeningMaternal symptomatologyAffective symptoms
2022
Effect of patient-delivered household contact tracing and prevention for tuberculosis: A household cluster-randomised trial in Malawi
Kaswaswa K, MacPherson P, Kumwenda M, Mpunga J, Thindwa D, Nliwasa M, Mwapasa M, Odland J, Tomoka T, Chipungu G, Mukaka M, Corbett E. Effect of patient-delivered household contact tracing and prevention for tuberculosis: A household cluster-randomised trial in Malawi. PLOS ONE 2022, 17: e0269219. PMID: 36074775, PMCID: PMC9455850, DOI: 10.1371/journal.pone.0269219.Peer-Reviewed Original ResearchConceptsTB preventive therapyStandard of careHousehold contactsNational guidelinesTB participantsEligible TB patientsMonths of randomisationCluster-randomised trialTRIAL REGISTRATION NUMBERHousehold contact tracingAge 5 yearsLow-resource settingsTB diseaseTB patientsPreventive therapySecondary outcomesTB screeningPrimary outcomeSymptom screeningIntervention armTB diagnosisSymptom screenMAIN OUTCOMEHigh riskTriage tool
2020
Reframing the early childhood obesity prevention narrative through an equitable nurturing approach
Skouteris H, Bergmeier HJ, Berns SD, Betancourt J, Boynton‐Jarrett R, Davis MB, Gibbons K, Pérez‐Escamilla R, Story M. Reframing the early childhood obesity prevention narrative through an equitable nurturing approach. Maternal And Child Nutrition 2020, 17: e13094. PMID: 33067918, PMCID: PMC7729646, DOI: 10.1111/mcn.13094.Peer-Reviewed Original ResearchConceptsChildhood obesity preventionWorld Health OrganizationChildhood obesityObesity preventionCare approachAge 5 yearsRace/ethnicityAdverse child experiencesObesity developmentHigher-quality mother–child (but not father–child) interactionsChild development outcomesDrivers of undernutritionMother-child dyadsObesityHolistic life course approachSocial determinantsCare frameworkHealth OrganizationLife course approachAge 5Mother-child interactionUndernutritionRecognition of racismPreventionPrevention narratives
2019
Paediatric tuberculosis transmission outside the household: challenging historical paradigms to inform future public health strategies
Martinez L, Lo N, Cords O, Hill P, Khan P, Hatherill M, Mandalakas A, Kay A, Croda J, Horsburgh C, Zar H, Andrews J. Paediatric tuberculosis transmission outside the household: challenging historical paradigms to inform future public health strategies. The Lancet Respiratory Medicine 2019, 7: 544-552. PMID: 31078497, PMCID: PMC7323920, DOI: 10.1016/s2213-2600(19)30137-7.Peer-Reviewed Original ResearchConceptsM tuberculosis transmissionHousehold contact tracingTuberculosis transmissionFuture public health strategiesContact tracingGlobal tuberculosis control effortsAdult tuberculosis casesPaediatric tuberculosis infectionMycobacterium tuberculosis transmissionHigh-burden settingsTuberculosis control effortsEffective public health responsePopulation attributable fractionPublic health strategiesAge 5 yearsCommunity-based interventionsPublic health interventionsPublic health responsePediatric transmissionChildhood tuberculosisTuberculosis infectionTuberculosis casesActive surveillanceHealth strategiesHousehold exposure
2018
1134 A morbidly obese type I diabetic teenager with sleep apnea, nocturnal eating, and Cushingoid features. Where to start?
Hawkins M, Williams C, Kryger M. 1134 A morbidly obese type I diabetic teenager with sleep apnea, nocturnal eating, and Cushingoid features. Where to start? Sleep 2018, 41: a419-a420. DOI: 10.1093/sleep/zsy063.1133.Peer-Reviewed Original ResearchObstructive sleep apneaMorning glucose levelsNocturnal eatingSleep apneaGlucose levelsDocumentation of hypoglycemiaInsulin resistance riskApnea-hypopnea indexSetting of diabetesBody mass indexDoses of insulinDiagnosis of diabetesAge 5 yearsAdverse health conditionsSalivary cortisol levelsType ICushingoid featuresPAP therapyCushingoid appearanceNight sweatsHypopnea indexHypothalamic dysfunctionPrompt treatmentCushing's diseaseNight-time behaviorClinical spectrum of pyruvate kinase deficiency: data from the Pyruvate Kinase Deficiency Natural History Study
Grace RF, Bianchi P, van Beers EJ, Eber SW, Glader B, Yaish HM, Despotovic JM, Rothman JA, Sharma M, McNaull MM, Fermo E, Lezon-Geyda K, Morton DH, Neufeld EJ, Chonat S, Kollmar N, Knoll CM, Kuo K, Kwiatkowski JL, Pospíšilová D, Pastore YD, Thompson AA, Newburger PE, Ravindranath Y, Wang WC, Wlodarski MW, Wang H, Holzhauer S, Breakey VR, Kunz J, Sheth S, Rose MJ, Bradeen HA, Neu N, Guo D, Al-Sayegh H, London WB, Gallagher PG, Zanella A, Barcellini W. Clinical spectrum of pyruvate kinase deficiency: data from the Pyruvate Kinase Deficiency Natural History Study. Blood 2018, 131: 2183-2192. PMID: 29549173, DOI: 10.1182/blood-2017-10-810796.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAnemia, Hemolytic, Congenital NonspherocyticBlood TransfusionChildChild, PreschoolCholecystectomyCombined Modality TherapyEnzyme ActivationFemaleGenetic Association StudiesGenotypeHumansInfantInfant, NewbornMaleMiddle AgedMutationPhenotypePyruvate KinasePyruvate Metabolism, Inborn ErrorsSplenectomySymptom AssessmentTreatment OutcomeYoung AdultConceptsIron overloadHemolytic anemiaPyruvate kinase deficiencyChildren age 5 yearsProspective clinical dataPK deficiencySeverity of anemiaKinase deficiencyNatural history studiesAge 5 yearsCongenital nonspherocytic hemolytic anemiaCongenital hemolytic anemiaBaseline hemoglobinPostsplenectomy thrombosisMulticenter registryPostsplenectomy sepsisPulmonary hypertensionSimultaneous cholecystectomyFrequent complicationPerinatal complicationsTransfusion burdenAplastic crisisExchange transfusionLeg ulcersRadiologic data
2015
Determinants of undernutrition among children aged 6 to 59 months in rural Zambézia Province, Mozambique: results of two population-based serial cross-sectional surveys
Rose ES, Blevins M, González-Calvo L, Ndatimana E, Green AF, Lopez M, Olupona O, Vermund SH, Moon TD, For the Ogumaniha-SCIP Zambézia Consortium. Determinants of undernutrition among children aged 6 to 59 months in rural Zambézia Province, Mozambique: results of two population-based serial cross-sectional surveys. BMC Nutrition 2015, 1: 41. PMID: 27182448, PMCID: PMC4864006, DOI: 10.1186/s40795-015-0039-1.Peer-Reviewed Original ResearchAge z-scoreCross-sectional surveyZ-scoreZambézia ProvincePopulation-based cross-sectional surveyRural Zambézia ProvinceSerial cross-sectional surveysHeight z-scoreOdds of stuntingAge 6 monthsPrevalence of stuntingAge 5 yearsDeterminants of undernutritionDietary diversity scoreNon-linear associationLower oddsAnthropometric measurementsGreater oddsHousehold food insecurityMultidimensional interventionsSTATA 13.1UndernutritionLogistic regressionUnderweightConclusionsA combination
2014
A CACNA1C Variant Associated with Reduced Voltage-Dependent Inactivation, Increased CaV1.2 Channel Window Current, and Arrhythmogenesis
Hennessey JA, Boczek NJ, Jiang YH, Miller JD, Patrick W, Pfeiffer R, Sutphin BS, Tester DJ, Barajas-Martinez H, Ackerman MJ, Antzelevitch C, Kanter R, Pitt GS. A CACNA1C Variant Associated with Reduced Voltage-Dependent Inactivation, Increased CaV1.2 Channel Window Current, and Arrhythmogenesis. PLOS ONE 2014, 9: e106982. PMID: 25184293, PMCID: PMC4153713, DOI: 10.1371/journal.pone.0106982.Peer-Reviewed Original ResearchConceptsSudden unexplained infant deathVoltage-dependent inactivationLong QT syndromeWindow currentTimothy syndromeCav1.2 L-type Ca2Multiple dental cariesLower extremity weaknessGain of functionCertain clinical settingsEpisodes of rhabdomyolysisUnexplained infant deathL-type Ca2Channel window currentAge 5 yearsYears of ageAppreciation of mechanismsMonths of ageCandidate gene sequencingCardiac ion channelsRecurrent VTExtremity weaknessSpastic diplegiaExtracardiac featuresDental cariesThe Epidemiology of Childhood and Adolescent Traumatic Spinal Cord Injury in the United States: 2007–2010
Selvarajah S, Schneider E, Becker D, Sadowsky C, Haider A, Hammond E. The Epidemiology of Childhood and Adolescent Traumatic Spinal Cord Injury in the United States: 2007–2010. Journal Of Neurotrauma 2014, 31: 1548-1560. PMID: 24811704, DOI: 10.1089/neu.2014.3332.Peer-Reviewed Original ResearchConceptsTraumatic spinal cord injuryAcute traumatic spinal cord injuryNew Injury Severity ScoreSpinal cord injuryCumulative incidenceCord injuryMedian New Injury Severity ScoreNationwide Emergency Department SampleChildren age 5 yearsConcurrent brain injuryNinth Revision diagnosisInjury Severity ScoreMajority of patientsOverall injury severityEmergency Department SampleInflation-adjusted chargesEpidemiology of childhoodChildren 5 yearsEmergency department dataAge 17 yearsAge 5 yearsRoad traffic accidentsDischarge dispositionMedian ageRevision diagnosis
1996
Biochemical and molecular analysis in a patient with the severe form of Hunter syndrome after bone marrow transplantation
Li P, Thompson J, Hug G, Huffman P, Chuck G. Biochemical and molecular analysis in a patient with the severe form of Hunter syndrome after bone marrow transplantation. American Journal Of Medical Genetics 1996, 64: 531-535. PMID: 8870917, DOI: 10.1002/(sici)1096-8628(19960906)64:4<531::aid-ajmg1>3.0.co;2-s.Peer-Reviewed Original ResearchConceptsBone marrow transplantationHunter syndromeMarrow transplantationLeukocyte DNAUrinary glycosaminoglycan excretionAge 2 yearsAge 5 yearsPolymerase chain reaction sequencingCultured skin fibroblastsGlycosaminoglycan excretionPrimary genetic defectMetabolic effectsUrinary glycosaminoglycansSevere formSyndromeSevere disease-causing mutationsLiver homogenatesNovel nonsense mutationMolecular analysisSkin fibroblastsDisease-causing mutationsReaction sequencingGenetic defectsPatientsTransplantation
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