Mepolizumab in patients with severe asthma & BEC ≥150–<300 cells/µL: Benefits at 2 years
Canonica G, Bagnasco D, Lee J, Chupp G, Schleich F, Oppenheimer J, Zhang L, Alfonso-Cristancho R, Howarth P. Mepolizumab in patients with severe asthma & BEC ≥150–<300 cells/µL: Benefits at 2 years. ERJ Open Research 2025, 01390-2024. DOI: 10.1183/23120541.01390-2024.Peer-Reviewed Original ResearchClinically significant exacerbationsBlood eosinophil countMaintenance oral corticosteroidsSevere asthmaRate of clinically significant exacerbationsMedian average daily doseFEV 1Effect of mepolizumabInitiation of mepolizumabProportion of patientsObservational cohort studyReal-world effectivenessClinical trial evidenceForced expiratory volumePoor disease controlMepolizumab treatmentAverage daily doseOral corticosteroidsSingle-armACQ-5Daily doseSignificant exacerbationsEosinophil countMepolizumabCohort studyProspective REALITI-A Study 2-Year Real-World Benefits of Mepolizumab in Severe Asthma
Caruso C, Canonica G, Patel M, Smith A, Liu M, Alfonso-Cristancho R, Price R, Jakes R, Demetriou L, Valero A, Köhler T, Pilette C, Chupp G, Brusselle G, Howarth P. Prospective REALITI-A Study 2-Year Real-World Benefits of Mepolizumab in Severe Asthma. CHEST Pulmonary 2025, 3: 100107. DOI: 10.1016/j.chpulm.2024.100107.Peer-Reviewed Original ResearchFollow-up periodMepolizumab treatmentAdverse eventsSevere asthmaRate of clinically significant asthma exacerbationsFollow-upMonoclonal antibodies targeting interleukin-5Clinically significant asthma exacerbationsMaintenance oral corticosteroidsAssociated with sustained reductionsProportion of patientsACQ-5 scoresAsthma Control QuestionnaireForced expiratory volumeOral corticosteroidsWell-toleratedACQ-5Clinical benefitMepolizumabProspective studyWeeks 0Asthma exacerbationsInterleukin-5Expiratory volumeSustained reduction
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