Genome sequencing is critical for forecasting outcomes following congenital cardiac surgery
Watkins W, Hernandez E, Miller T, Blue N, Zimmerman R, Griffiths E, Frise E, Bernstein D, Boskovski M, Brueckner M, Chung W, Gaynor J, Gelb B, Goldmuntz E, Gruber P, Newburger J, Roberts A, Morton S, Mayer J, Seidman C, Seidman J, Shen Y, Wagner M, Yost H, Yandell M, Tristani-Firouzi M. Genome sequencing is critical for forecasting outcomes following congenital cardiac surgery. Nature Communications 2025, 16: 6365. PMID: 40640177, PMCID: PMC12246213, DOI: 10.1038/s41467-025-61625-0.Peer-Reviewed Original ResearchConceptsCongenital heart defectsCongenital cardiac surgeryCilia-related genesGenome sequenceChromatin modifiersCardiac surgeryExome sequencingHeart defectsClinical outcomesRisk of adverse post-operative outcomesPediatric Cardiac Genomics ConsortiumCongenital heart defect phenotypesCongenital heart defect patientsAdverse post-operative outcomesWhole-genome sequencingPredictive valueExtra-cardiac anomaliesProspective observational cohort studyComplex heart defectsPost-operative outcomesWhole-exome sequencingElevated riskAdverse postoperative outcomesObservational cohort studyPostoperative outcomes
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