2024
Acute Promyelocytic Leukemia in the Real World: Understanding Outcome Differences and How We Can Improve Them
Bidikian A, Bewersdorf J, Kewan T, Stahl M, Zeidan A. Acute Promyelocytic Leukemia in the Real World: Understanding Outcome Differences and How We Can Improve Them. Cancers 2024, 16: 4092. PMID: 39682277, PMCID: PMC11640703, DOI: 10.3390/cancers16234092.Peer-Reviewed Original ResearchAcute promyelocytic leukemiaAdvent of all-trans retinoic acidEarly mortalityLong-term treatment toxicitiesArsenic trioxidePromyelocytic leukemiaClinical practiceIncidence of acute promyelocytic leukemiaRates of remissionLong-term outcomesTreatment of acute promyelocytic leukemiaLong-term survivalComprehensive patient evaluationResource-limited settingsTreatment toxicityAll-Trans Retinoic AcidDelayed DiagnosisPatient demographicsSignificant comorbiditiesTreatment initiationOlder patientsExpert centersClinical trialsTreatment outcomesReal-world settingsPCR104 Asthma Characteristics and Patient-Reported Outcomes in Patients With Atopic Dermatitis in the Rapid Registry of Dupilumab Use in a Real-World Setting
Mosnaim G, Peters A, Lugogo N, Price D, Côté A, Plaza V, Xia C, Gómez L, Kwah J. PCR104 Asthma Characteristics and Patient-Reported Outcomes in Patients With Atopic Dermatitis in the Rapid Registry of Dupilumab Use in a Real-World Setting. Value In Health 2024, 27: s525. DOI: 10.1016/j.jval.2024.10.3347.Peer-Reviewed Original ResearchLoncastuximab in high-risk and heavily pretreated relapsed/refractory diffuse large B-cell lymphoma: a real-world analysis from 21 US centers
Zelikson V, Gurumurthi A, Sawalha Y, Annunzio K, Saha A, Dong N, Qualls D, Amoozgar B, Kahl B, Baird J, Challa P, Huntington S, Santos J, Bair S, Narkhede M, Li S, Frosch Z, Ho C, Smith S, Winter A, Landsburg D, Furqan F, Hamadani M, Baird K, Romancik J, Alharthy H, Law J, Bojanini L, Advani R, Hu B, Johnson P, Grover N, Merril M, Crombie J, Shafagati N, Sterling C, Nastoupil L, Epperla N, Ayers E. Loncastuximab in high-risk and heavily pretreated relapsed/refractory diffuse large B-cell lymphoma: a real-world analysis from 21 US centers. Haematologica 2024, 110: 706-714. PMID: 39540227, PMCID: PMC11873705, DOI: 10.3324/haematol.2024.285977.Peer-Reviewed Original ResearchLOTIS-2Overall response rateOverall survivalAntibody drug conjugatesBulky diseaseComplete responseRefractory diffuse large B-cell lymphomaUS CentersDiffuse large B-cell lymphomaLarge B-cell lymphomaEvaluate outcomes of patientsHigh riskResponse rateB-cell histologyR/R DLBCL patientsPre-treated patientsB-cell lymphomaOutcomes of patientsProportion of patientsRetrospective cohort studyCell of originDLBCL patientsReal-world settingsRetrospective studyReal-world analysisComparing the brief Holistic Health for HIV (3H+) to the Holistic Health Recovery Program (HHRP+) among people with HIV and opioid use disorder: Results from a randomized, controlled non-inferiority trial
Zelenev A, Huedo-Medina T, Shrestha R, Mistler C, Altice F, Sibilio B, Copenhaver M. Comparing the brief Holistic Health for HIV (3H+) to the Holistic Health Recovery Program (HHRP+) among people with HIV and opioid use disorder: Results from a randomized, controlled non-inferiority trial. PLOS ONE 2024, 19: e0312165. PMID: 39509356, PMCID: PMC11542883, DOI: 10.1371/journal.pone.0312165.Peer-Reviewed Original ResearchConceptsHolistic Health Recovery ProgramEvidence-based interventionsHolistic healthHIV treatmentRisk behaviorsReduce HIV risk behaviorsDifference-in-differencesEnd-of-interventionControlled non-inferiority trialHIV Epidemic goalsDrug treatment settingsAttainment of viral suppressionNon-inferiority trialRecovery programViral suppressionHigh ART adherenceHIV risk behaviorsNon-inferiorityHHRP+ART adherenceBehavioral interventionsReal-world settingsNon-parametric bootstrappingCondom useOpioid-dependent peopleImplementing LGBTQ-affirmative cognitive-behavioral therapy: implementation strategies across five clinical trials
Harkness A, Soulliard Z, Layland E, Behari K, Rogers B, Bharat B, Safren S, Pachankis J. Implementing LGBTQ-affirmative cognitive-behavioral therapy: implementation strategies across five clinical trials. Implementation Science Communications 2024, 5: 124. PMID: 39501392, PMCID: PMC11539333, DOI: 10.1186/s43058-024-00657-x.Peer-Reviewed Original ResearchCognitive-behavioral therapyImplementation strategiesEvidence-based treatmentsBehavioral health concernsPublic health benefitsComplex interventionsLGBTQ individualsReal-world settingsReporting toolHealth concernSurvey responsesHealth benefitsLevel of resourcesInterventionTrialsModerate priorityPriorityClinical trialsIndividualsImplementationDependent strategiesFindingsIntegrating Multimodal Affective Signals for Stress Detection from Audio-Visual Data
Ghose D, Gitelson O, Scassellati B. Integrating Multimodal Affective Signals for Stress Detection from Audio-Visual Data. 2024, 22-32. DOI: 10.1145/3678957.3685717.Peer-Reviewed Original ResearchAudio-visual dataLate fusionStress detectionF1 scoreMultimodal fusion methodDetect stressHuman emotional expressionsAblation studiesUnimodal classifiersEDA sensorsFusion methodIntermediate fusionFusion techniqueFacial expressionsModes of informationVideo clipsTextual sentimentEveryday environmentsReal-world settingsAudio-visualTraditional methodsVocal prosodySensorMeasurement of physiological responsesClassifierHMA/VEN treatment modifications and associated outcomes in IDH-mutant AML
Chin K, Derkach A, Famulare C, Gupta G, Borge P, Geyer M, Goldberg A, Haque T, Park J, Roeker L, Tallman M, Stahl M, Stein E. HMA/VEN treatment modifications and associated outcomes in IDH-mutant AML. Leukemia & Lymphoma 2024, 66: 270-278. PMID: 39397429, DOI: 10.1080/10428194.2024.2411436.Peer-Reviewed Original ResearchConceptsAcute myeloid leukemiaTreatment modificationHypomethylating agentsResponse rateAssociated with lower response ratesMedian overall survivalIDH-mutated acute myeloid leukemiaLong-term toxicityCR/CRi rateSignificant neutropeniaFebrile neutropeniaInduction chemotherapyOverall survivalMyeloid leukemiaLow response rateSurvival rateAffect SurvivalNeutropeniaVenetoclaxSurvivalED visitsPatientsR/RMonthsReal-world settingsReal-world impact of acupuncture on analgesics and healthcare resource utilization in breast cancer survivors with pain
Ng D, Lee S, Lee R, Wang Y, Chan A. Real-world impact of acupuncture on analgesics and healthcare resource utilization in breast cancer survivors with pain. BMC Medicine 2024, 22: 394. PMID: 39285302, PMCID: PMC11406884, DOI: 10.1186/s12916-024-03626-2.Peer-Reviewed Original ResearchConceptsBreast cancer survivorsImpact of acupunctureCancer survivorsHealthcare resource utilizationHealthcare costsAcupuncture-treated patientsHigh-utilizing patientsTotal healthcare costsShort-term opioidsCommercial health insuranceAcupuncture utilizationAcupuncture-treatedPost-acupunctureAcupuncture effectsPrevalence of opioidsMusculoskeletal painAcupunctureCancer diagnosisHealth insuranceReal-world settingsNSAID usePrescription fillsHealthcareUnited StatesResource utilizationArtificial-Intelligence Cloud-Based Platform to Support Shared Decision-Making in the Locoregional Treatment of Breast Cancer: Protocol for a Multidimensional Evaluation Embedded in the CINDERELLA Clinical Trial
Borsoi L, Listorti E, Ciani O. Artificial-Intelligence Cloud-Based Platform to Support Shared Decision-Making in the Locoregional Treatment of Breast Cancer: Protocol for a Multidimensional Evaluation Embedded in the CINDERELLA Clinical Trial. PharmacoEconomics - Open 2024, 8: 945-959. PMID: 39264499, PMCID: PMC11499581, DOI: 10.1007/s41669-024-00519-1.Peer-Reviewed Original ResearchBreast cancer patientsBackgroundShared decision-makingBreast cancer careCloud-based approachPatient decision aidsMultidimensional evaluationCloud-based platformReduce decision regretCost-utility analysisCancer patientsCancer carePatient-level dataHealthcare professionalsArtificial-intelligenceMobile applicationsPersonalized contentDecision regretCountry-specific unit costsFocus groupsLocoregional treatmentPatient questionnaireDecision aidPatient valuationsReal-world settingsWeb platformAssociation Between the Decipher Genomic Classifier and Prostate Cancer Outcome in the Real-world Setting
Leapman M, Ho J, Liu Y, Filson C, Zhao X, Hakansson A, Proudfoot J, Davicioni E, Martin D, An Y, Seibert T, Lin D, Spratt D, Cooperberg M, Sprenkle P, Ross A. Association Between the Decipher Genomic Classifier and Prostate Cancer Outcome in the Real-world Setting. European Urology Oncology 2024 PMID: 39098389, DOI: 10.1016/j.euo.2024.07.010.Peer-Reviewed Original ResearchDecipher genomic classifierRisk of metastasisBiochemical recurrenceRadical prostatectomyGenomic classifierDecipher testProstate cancerProstate Risk Assessment Postsurgical ScoreRisk of biochemical recurrencePatient's prostate cancerRisk of cancer recurrencePathological risk factorsProstate cancer outcomesCox proportional hazards regressionRetrospective cohort studyElectronic health record dataReal-world settingsProportional hazards regressionHealth record dataReal-world practice settingsProstate biopsyRP specimensOncological outcomesPrognostic significanceMedian ageUsability Testing Via Simulation
Wing R, Goldman M, Prieto M, Miller K, Baluyot M, Tay K, Bharath A, Patel D, Greenwald E, Larsen E, Polikoff L, Kerrey B, Nishisaki A, Nagler J. Usability Testing Via Simulation. Pediatric Emergency Care 2024, 40: 575-581. PMID: 39078284, DOI: 10.1097/pec.0000000000003223.Peer-Reviewed Original ResearchConceptsPediatric emergency medicinePreintubation checklistEmergency medicineChecklist itemsImplementation science strategiesMixed methods studyModified Delphi approachPediatric emergency departmentDebriefing dataChecklist completionFramework approachUsability testingStructured debriefingMethods studyAttending physiciansEmergency departmentDelphi approachReal-world settingsUsability surveyPatient outcomesChecklistDebriefingTeam leadersNext stepsScience strategiesDevelopment and multinational validation of an algorithmic strategy for high Lp(a) screening
Aminorroaya A, Dhingra L, Oikonomou E, Saadatagah S, Thangaraj P, Vasisht Shankar S, Spatz E, Khera R. Development and multinational validation of an algorithmic strategy for high Lp(a) screening. Nature Cardiovascular Research 2024, 3: 558-566. PMID: 39195936, PMCID: PMC12190734, DOI: 10.1038/s44161-024-00469-1.Peer-Reviewed Original ResearchElectronic health recordsAssociated with premature atherosclerotic cardiovascular diseaseElevated Lp(aHealth recordsUK BiobankPremature atherosclerotic cardiovascular diseaseMachine learning modelsAtherosclerotic cardiovascular diseaseCohort studyReal-world settingsTargeted screeningCardiovascular diseaseLearning modelsNovel targeted therapeuticsAlgorithmic strategiesCohortProbability thresholdScreeningClinical featuresValidation cohortElevated lipoproteinRisk inspectionARICLp(aLessons learned from implementation of four HIV self-testing (HIVST) distribution models in Zambia: applying the Consolidated Framework for Implementation Research to understand impact of contextual factors on implementation
Simwinga M, Gwanu L, Hensen B, Sigande L, Mainga M, Phiri T, Mwanza E, Kabumbu M, Mulubwa C, Mwenge L, Bwalya C, Kumwenda M, Mubanga E, Mee P, Johnson C, Corbett E, Hatzold K, Neuman M, Ayles H, Taegtmeyer M. Lessons learned from implementation of four HIV self-testing (HIVST) distribution models in Zambia: applying the Consolidated Framework for Implementation Research to understand impact of contextual factors on implementation. BMC Infectious Diseases 2024, 22: 977. PMID: 38448832, PMCID: PMC10916003, DOI: 10.1186/s12879-024-09168-5.Peer-Reviewed Original ResearchConceptsConsolidated Framework for Implementation ResearchHIV self-testingHuman immunodeficiency virus self-testingImplementation researchHIV self-test distributionContextual factorsCombination of contextual factorsImpact of contextual factorsHuman immunodeficiency virusProvider experienceIncrease test coverageSelf-testingCommunity-led modelThematic approachProspective case studyExcessive workloadReal-world settingsGroup discussionsCommunity-ledWorld settingsParticipantsContextual experiencesInadequate compensationMonetary incentivesZambiaIdentification of Suicide Risk in a Pediatric Psychiatric Emergency Setting: Comparing the Ask Suicide-Screening Questions and the Kiddie-Computerized Adaptive Test-Suicide Scale
Cervantes P, Gibbons R, Seag D, Baroni A, Li A, Horwitz S. Identification of Suicide Risk in a Pediatric Psychiatric Emergency Setting: Comparing the Ask Suicide-Screening Questions and the Kiddie-Computerized Adaptive Test-Suicide Scale. Evidence-Based Practice In Child And Adolescent Mental Health 2024, 9: 561-574. PMID: 39872043, PMCID: PMC11771990, DOI: 10.1080/23794925.2024.2303778.Peer-Reviewed Original ResearchAsk Suicide-Screening QuestionsPsychiatric emergency settingSuicide risk screeningSuicide riskEmergency departmentRisk screeningPresence of suicide riskIdentification of suicide riskLower symptom levelsCases of disagreementImplementation of mental health screeningSample of participantsMental health screeningMental health domainsEmergency settingSymptom levelsInternalizing disordersPsychiatric symptomsCharacteristics of youthIdentifying youthCaregiver reportsEducational accommodationsHealth screeningHealth domainsReal-world settings
2023
A narrative review of digital biomarkers in the management of major depressive disorder and treatment-resistant forms
Vignapiano A, Monaco F, Pagano C, Piacente M, Farina F, Petrillo G, Sica R, Marenna A, Shin J, Solmi M, Corrivetti G. A narrative review of digital biomarkers in the management of major depressive disorder and treatment-resistant forms. Frontiers In Psychiatry 2023, 14: 1321345. PMID: 38076697, PMCID: PMC10701678, DOI: 10.3389/fpsyt.2023.1321345.Peer-Reviewed Original ResearchDepressive disorderSymptom severityPredicting diagnostic statusTreatment-resistant formsPredicting Treatment OutcomeMDD pathophysiologyDiagnostic statusMood disordersReal wordsIdentifying treatment responseDepression diagnosisEcological validityEffects of therapyMDDDepressionRelapse riskTreatment responseTreatment outcomesCore aspectsDisordersInclusion criteriaReal-world settingsPersonalized medicineFull recoveryBiomarkersAutoCriteria: a generalizable clinical trial eligibility criteria extraction system powered by large language models
Datta S, Lee K, Paek H, Manion F, Ofoegbu N, Du J, Li Y, Huang L, Wang J, Lin B, Xu H, Wang X. AutoCriteria: a generalizable clinical trial eligibility criteria extraction system powered by large language models. Journal Of The American Medical Informatics Association 2023, 31: 375-385. PMID: 37952206, PMCID: PMC10797270, DOI: 10.1093/jamia/ocad218.Peer-Reviewed Original ResearchConceptsLanguage modelInformation extraction systemOverall F1 scoreCriteria informationF1 scoreManual annotationScalable solutionContextual informationComplex scenariosContextual attributesExtraction systemReal-world settingsSystem evaluationModeling capabilitiesClinical trial protocol documentsInformationProtocol documents
2022
Recovery Coaching In and Out of Emergency Departments: an Overview of the Connecticut Community for Addiction Recovery’s (CCAR) Emergency Department Recovery Coaching Program
Stanojlović M, Allen R, Valentine P, Davidson L, O’Connell M. Recovery Coaching In and Out of Emergency Departments: an Overview of the Connecticut Community for Addiction Recovery’s (CCAR) Emergency Department Recovery Coaching Program. International Journal Of Mental Health And Addiction 2022, 21: 3033-3042. DOI: 10.1007/s11469-022-00772-7.Peer-Reviewed Original ResearchRecovery coachesCoaching programED staff educationRecovery coaching servicesFollow-up careAddiction recoveryProfessional support networksConnecticut communitiesStaff educationIncreased risk of overdoseSubstance use disordersAppropriate careRisk of overdoseCoaching servicesEmergency departmentSupport networksReal-world settingsBuy-inInvestment of resourcesIncreased riskRelationship buildingCoachingUse disorderCareFinancial compensation
2021
Neuropsychological adverse drug reactions of Remdesivir: analysis using VigiBase, the WHO global database of individual case safety reports.
Lee S, Yang J, Jung S, Kim M, Yon D, Lee S, Kang H, Dragioti E, Tizaoui K, Jacob L, Koyanagi A, Salem J, Kostev K, Lascu A, Shin J, Kim J, Smith L. Neuropsychological adverse drug reactions of Remdesivir: analysis using VigiBase, the WHO global database of individual case safety reports. European Review For Medical And Pharmacological Sciences 2021, 25: 7390-7397. PMID: 34919240, DOI: 10.26355/eurrev_202112_27435.Peer-Reviewed Original ResearchConceptsAdverse reactionsIndividual case safety reportsReal-world settingsWorld Health Organization databaseCase safety reportsWHO global database of individual case safety reportsSafety reportsPharmacovigilance cohort studyNeural network methodAdverse drug reactionsAssociated with remdesivirBayesian neural network methodCohort studyPandemic outbreak of coronavirus disease 2019Clinical benefitWHO global databaseTreatment of COVID-19Remdesivir useDrug reactionsInformation componentNeuropsychological dysfunctionGS-5734Pharmacovigilance signalsCoronavirus disease 2019Outbreak of coronavirus disease 2019
2020
Causal Relational Learning
Salimi B, Parikh H, Kayali M, Getoor L, Roy S, Suciu D. Causal Relational Learning. 2020, 241-256. DOI: 10.1145/3318464.3389759.Peer-Reviewed Original ResearchRelational dataDatalog-like rulesMultiple relational tablesComplex relational structuresDeclarative languageRelational tablesExperimental evaluationReal-world settingsCost constraintsRelational domainsInferenceRelational structureCausal inferenceDecision makingScientific discoverySocial sciencesHeterogeneous elementsDomainInformed decision makingHomogeneous elementsFrameworkRulesConstraintsLanguageData
2019
Combination Antihypertensive Therapy Prescribing and Blood Pressure Control in a Real-World Setting
Magvanjav O, Cooper-Dehoff R, McDonough C, Gong Y, Hogan W, Johnson J. Combination Antihypertensive Therapy Prescribing and Blood Pressure Control in a Real-World Setting. American Journal Of Hypertension 2019, 33: 316-324. PMID: 31853537, PMCID: PMC7109351, DOI: 10.1093/ajh/hpz196.Peer-Reviewed Original ResearchConceptsElectronic health recordsDrug class combinationsBP controlElectronic health record dataClinical decision supportDrug classesEvidence of associationHistory of myocardial infarctionImprove BP controlHealthcare ImprovementConcomitant diseasesUncomplicated hypertensionHealth recordsMyocardial infarctionBlood pressureManagement of hypertensionDual antihypertensive therapyPrescribing practicesReal-world settingsPrescribingAntihypertensive drug classesBlood pressure controlPrescribing patternsAmbulatory hypertensive patientsPrescribed frequency
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